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Patent code US9675612

Compile Data Set for Download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176795
PNG
(US9675612, 33 {7-[(6-Methoxy-1H-indazol-5-yl)amino...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C19H19N7O2S/c1-28-14-8-12-11(9-22-25-12)7-13(14)23-16-15-17(21-10-20-16)29-18(24-15)19(27)26-5-3-2-4-6-26/h7-10H,2-6H2,1H3,(H,22,25)(H,20,21,23)
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n/an/a 17n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176749
PNG
(US9675612, 4 2-Benzyl-N-(6-methoxy-1H-indazol-5-yl...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(Cc3ccccc3)nc12
Show InChI InChI=1S/C20H16N6OS/c1-27-16-9-14-13(10-23-26-14)8-15(16)24-19-18-20(22-11-21-19)28-17(25-18)7-12-5-3-2-4-6-12/h2-6,8-11H,7H2,1H3,(H,23,26)(H,21,22,24)
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n/an/a 20n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176754
PNG
(US9675612, 5 N-(6-Methoxy-1H-indazol-5-yl)-2-(meth...)
Show SMILES COCc1nc2c(Nc3cc4cn[nH]c4cc3OC)ncnc2s1
Show InChI InChI=1S/C15H14N6O2S/c1-22-6-12-20-13-14(16-7-17-15(13)24-12)19-10-3-8-5-18-21-9(8)4-11(10)23-2/h3-5,7H,6H2,1-2H3,(H,18,21)(H,16,17,19)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176814
PNG
(US9675612, 47 N-[3-(Dimethylamino)-3-oxopropyl]-7-...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CCC(=O)N(C)C
Show InChI InChI=1S/C22H26N8O3S/c1-12(2)33-16-9-14-13(10-25-28-14)8-15(16)26-19-18-20(24-11-23-19)34-21(27-18)22(32)30(5)7-6-17(31)29(3)4/h8-12H,6-7H2,1-5H3,(H,25,28)(H,23,24,26)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176796
PNG
(US9675612, 34 {7-[(6-Ethoxy-1H-indazol-5-yl)amino]...)
Show SMILES CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N7O2S/c1-2-29-15-9-13-12(10-23-26-13)8-14(15)24-17-16-18(22-11-21-17)30-19(25-16)20(28)27-6-4-3-5-7-27/h8-11H,2-7H2,1H3,(H,23,26)(H,21,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176767
PNG
(US9675612, 11 2-Benzyl-N-(1H-indazol-5-yl)[1,3]thi...)
Show SMILES C(c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1)c1ccccc1
Show InChI InChI=1S/C19H14N6S/c1-2-4-12(5-3-1)8-16-24-17-18(20-11-21-19(17)26-16)23-14-6-7-15-13(9-14)10-22-25-15/h1-7,9-11H,8H2,(H,22,25)(H,20,21,23)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176763
PNG
(US9675612, 9 2-(Cyclopropylmethyl)-N-(1H-indazol-5...)
Show SMILES C(C1CC1)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C16H14N6S/c1-2-9(1)5-13-21-14-15(17-8-18-16(14)23-13)20-11-3-4-12-10(6-11)7-19-22-12/h3-4,6-9H,1-2,5H2,(H,19,22)(H,17,18,20)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176777
PNG
(US9675612, 20 2-[(Benzyloxy)methyl]-N-(6-methoxy-1...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(COCc3ccccc3)nc12
Show InChI InChI=1S/C21H18N6O2S/c1-28-17-8-15-14(9-24-27-15)7-16(17)25-20-19-21(23-12-22-20)30-18(26-19)11-29-10-13-5-3-2-4-6-13/h2-9,12H,10-11H2,1H3,(H,24,27)(H,22,23,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176745
PNG
(US9675612, 1 6-{[2-(Cyclopropylmethyl)[1,3]thiazol...)
Show SMILES O=c1[nH]c2ccc(Nc3ncnc4sc(CC5CC5)nc34)cc2s1
Show InChI InChI=1S/C16H13N5OS2/c22-16-20-10-4-3-9(6-11(10)23-16)19-14-13-15(18-7-17-14)24-12(21-13)5-8-1-2-8/h3-4,6-8H,1-2,5H2,(H,20,22)(H,17,18,19)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176779
PNG
(US9675612, 22 N-(6-Methoxy-1H-indazol-5-yl)-2-(2-p...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(CCc3ccccc3)nc12
Show InChI InChI=1S/C21H18N6OS/c1-28-17-10-15-14(11-24-27-15)9-16(17)25-20-19-21(23-12-22-20)29-18(26-19)8-7-13-5-3-2-4-6-13/h2-6,9-12H,7-8H2,1H3,(H,24,27)(H,22,23,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176791
PNG
(US9675612, 30 7-[(6-Ethoxy-1H-indazol-5-yl)amino]-...)
Show SMILES CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C
Show InChI InChI=1S/C17H17N7O2S/c1-4-26-12-6-10-9(7-20-23-10)5-11(12)21-14-13-15(19-8-18-14)27-16(22-13)17(25)24(2)3/h5-8H,4H2,1-3H3,(H,20,23)(H,18,19,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176772
PNG
(US9675612, 15 N-(6-Methoxy-1H-indazol-5-yl)[1,3]th...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2scnc12
Show InChI InChI=1S/C13H10N6OS/c1-20-10-3-8-7(4-17-19-8)2-9(10)18-12-11-13(15-5-14-12)21-6-16-11/h2-6H,1H3,(H,17,19)(H,14,15,18)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176803
PNG
(US9675612, 40 N-[3-(Dimethylamino)-3-oxopropyl]-7-...)
Show SMILES CN(C)C(=O)CCN(C)C(=O)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C19H20N8O2S/c1-26(2)14(28)6-7-27(3)19(29)18-24-15-16(20-10-21-17(15)30-18)23-12-4-5-13-11(8-12)9-22-25-13/h4-5,8-10H,6-7H2,1-3H3,(H,22,25)(H,20,21,23)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176780
PNG
(US9675612, 23 N-(1H-indazol-5-yl)-2-(2-phenylethyl...)
Show SMILES C(Cc1ccccc1)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C20H16N6S/c1-2-4-13(5-3-1)6-9-17-25-18-19(21-12-22-20(18)27-17)24-15-7-8-16-14(10-15)11-23-26-16/h1-5,7-8,10-12H,6,9H2,(H,23,26)(H,21,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176807
PNG
(US9675612, 44 N,N-Dimethyl-7-{[6-(propan-2-yloxy)-...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C
Show InChI InChI=1S/C18H19N7O2S/c1-9(2)27-13-6-11-10(7-21-24-11)5-12(13)22-15-14-16(20-8-19-15)28-17(23-14)18(26)25(3)4/h5-9H,1-4H3,(H,21,24)(H,19,20,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176766
PNG
(US9675612, 10 2-Cyclobutyl-N-(1H-indazol-5-yl)[1,3...)
Show SMILES C1CC(C1)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C16H14N6S/c1-2-9(3-1)15-21-13-14(17-8-18-16(13)23-15)20-11-4-5-12-10(6-11)7-19-22-12/h4-9H,1-3H2,(H,19,22)(H,17,18,20)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176761
PNG
(US9675612, 8 2-Cyclohexyl-N-(1H-indazol-5-yl)[1,3]...)
Show SMILES C1CCC(CC1)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C18H18N6S/c1-2-4-11(5-3-1)17-23-15-16(19-10-20-18(15)25-17)22-13-6-7-14-12(8-13)9-21-24-14/h6-11H,1-5H2,(H,21,24)(H,19,20,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176808
PNG
(US9675612, 45 N-[2-(Dimethylamino)-2-oxoethyl]-7-[...)
Show SMILES CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CC(=O)N(C)C
Show InChI InChI=1S/C20H22N8O3S/c1-5-31-14-7-12-11(8-23-26-12)6-13(14)24-17-16-18(22-10-21-17)32-19(25-16)20(30)28(4)9-15(29)27(2)3/h6-8,10H,5,9H2,1-4H3,(H,23,26)(H,21,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176799
PNG
(US9675612, 36 N-[2-(Dimethylamino)-2-oxoethyl]-7-(...)
Show SMILES CN(C)C(=O)CN(C)C(=O)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C18H18N8O2S/c1-25(2)13(27)8-26(3)18(28)17-23-14-15(19-9-20-16(14)29-17)22-11-4-5-12-10(6-11)7-21-24-12/h4-7,9H,8H2,1-3H3,(H,21,24)(H,19,20,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176783
PNG
(US9675612, 26 4-{7-[(6-Methoxy-1H-indazol-5-yl)ami...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(CCCC(=O)N(C)C)nc12
Show InChI InChI=1S/C19H21N7O2S/c1-26(2)16(27)6-4-5-15-24-17-18(20-10-21-19(17)29-15)23-13-7-11-9-22-25-12(11)8-14(13)28-3/h7-10H,4-6H2,1-3H3,(H,22,25)(H,20,21,23)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176746
PNG
(US9675612, 2 6-[(2-Cyclobutyl[1,3]thiazolo[5,4-d]p...)
Show SMILES O=c1[nH]c2ccc(Nc3ncnc4sc(nc34)C3CCC3)cc2s1
Show InChI InChI=1S/C16H13N5OS2/c22-16-20-10-5-4-9(6-11(10)23-16)19-13-12-15(18-7-17-13)24-14(21-12)8-2-1-3-8/h4-8H,1-3H2,(H,20,22)(H,17,18,19)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176802
PNG
(US9675612, 39 N-[2-(Dimethylamino)-2-oxoethyl]-N-m...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CC(=O)N(C)C
Show InChI InChI=1S/C21H24N8O3S/c1-11(2)32-15-7-13-12(8-24-27-13)6-14(15)25-18-17-19(23-10-22-18)33-20(26-17)21(31)29(5)9-16(30)28(3)4/h6-8,10-11H,9H2,1-5H3,(H,24,27)(H,22,23,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176778
PNG
(US9675612, 21 3-[7-(1H-Indazol-5-ylamino)[1,3]thia...)
Show SMILES CN(C)C(=O)CCc1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C17H17N7OS/c1-24(2)14(25)6-5-13-22-15-16(18-9-19-17(15)26-13)21-11-3-4-12-10(7-11)8-20-23-12/h3-4,7-9H,5-6H2,1-2H3,(H,20,23)(H,18,19,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176798
PNG
(US9675612, 35 Piperidin-1-yl(7-{[6-(propan-2-yloxy...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C21H23N7O2S/c1-12(2)30-16-9-14-13(10-24-27-14)8-15(16)25-18-17-19(23-11-22-18)31-20(26-17)21(29)28-6-4-3-5-7-28/h8-12H,3-7H2,1-2H3,(H,24,27)(H,22,23,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176775
PNG
(US9675612, 18 5-Methoxy-6-([1,3]thiazolo[5,4-d]pyr...)
Show SMILES COc1cc2[nH]c(=O)sc2cc1Nc1ncnc2scnc12
Show InChI InChI=1S/C13H9N5O2S2/c1-20-8-2-7-9(22-13(19)18-7)3-6(8)17-11-10-12(15-4-14-11)21-5-16-10/h2-5H,1H3,(H,18,19)(H,14,15,17)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176770
PNG
(US9675612, 13 4-[7-(1H-Indazol-5-ylamino)[1,3]thia...)
Show SMILES CN(C)C(=O)CCCc1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C18H19N7OS/c1-25(2)15(26)5-3-4-14-23-16-17(19-10-20-18(16)27-14)22-12-6-7-13-11(8-12)9-21-24-13/h6-10H,3-5H2,1-2H3,(H,21,24)(H,19,20,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176805
PNG
(US9675612, 42 N-[3-(Dimethylamino)-3-oxopropyl]-7-...)
Show SMILES CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CCC(=O)N(C)C
Show InChI InChI=1S/C21H24N8O3S/c1-5-32-15-9-13-12(10-24-27-13)8-14(15)25-18-17-19(23-11-22-18)33-20(26-17)21(31)29(4)7-6-16(30)28(2)3/h8-11H,5-7H2,1-4H3,(H,24,27)(H,22,23,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176771
PNG
(US9675612, 14 1-(3-Hydroxy-3-methylazetidin-1-yl)-...)
Show SMILES CC1(O)CN(C1)C(=O)CCc1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C19H19N7O2S/c1-19(28)8-26(9-19)15(27)5-4-14-24-16-17(20-10-21-18(16)29-14)23-12-2-3-13-11(6-12)7-22-25-13/h2-3,6-7,10,28H,4-5,8-9H2,1H3,(H,22,25)(H,20,21,23)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176801
PNG
(US9675612, 38 N-[2-(Dimethylamino)-2-oxoethyl]-7-[...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CC(=O)N(C)C
Show InChI InChI=1S/C19H20N8O3S/c1-26(2)14(28)8-27(3)19(29)18-24-15-16(20-9-21-17(15)31-18)23-12-5-10-7-22-25-11(10)6-13(12)30-4/h5-7,9H,8H2,1-4H3,(H,22,25)(H,20,21,23)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176794
PNG
(US9675612, 32 6-{[2-(Piperidin-1-ylcarbonyl)[1,3]t...)
Show SMILES O=C(N1CCCCC1)c1nc2c(Nc3ccc4[nH]c(=O)sc4c3)ncnc2s1
Show InChI InChI=1S/C18H16N6O2S2/c25-17(24-6-2-1-3-7-24)16-23-13-14(19-9-20-15(13)28-16)21-10-4-5-11-12(8-10)27-18(26)22-11/h4-5,8-9H,1-3,6-7H2,(H,22,26)(H,19,20,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176776
PNG
(US9675612, 19 6-([1,3]Thiazolo[5,4-d]pyrimidin-7-y...)
Show SMILES O=c1[nH]c2ccc(Nc3ncnc4scnc34)cc2s1
Show InChI InChI=1S/C12H7N5OS2/c18-12-17-7-2-1-6(3-8(7)20-12)16-10-9-11(14-4-13-10)19-5-15-9/h1-5H,(H,17,18)(H,13,14,16)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176769
PNG
(US9675612, 12 1-(3-Hydroxy-3-methylazetidin-1-yl)-...)
Show SMILES CC1(O)CN(C1)C(=O)CCCc1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C20H21N7O2S/c1-20(29)9-27(10-20)16(28)4-2-3-15-25-17-18(21-11-22-19(17)30-15)24-13-5-6-14-12(7-13)8-23-26-14/h5-8,11,29H,2-4,9-10H2,1H3,(H,23,26)(H,21,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176810
PNG
(US9675612, 46 N-[3-(Dimethylamino)-3-oxopropyl]-7-...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CCC(=O)N(C)C
Show InChI InChI=1S/C20H22N8O3S/c1-27(2)15(29)5-6-28(3)20(30)19-25-16-17(21-10-22-18(16)32-19)24-13-7-11-9-23-26-12(11)8-14(13)31-4/h7-10H,5-6H2,1-4H3,(H,23,26)(H,21,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176773
PNG
(US9675612, 16 N-(1H-Indazol-5-yl)[1,3]thiazolo[5,4...)
Show SMILES N(c1ccc2[nH]ncc2c1)c1ncnc2scnc12
Show InChI InChI=1S/C12H8N6S/c1-2-9-7(4-16-18-9)3-8(1)17-11-10-12(14-5-13-11)19-6-15-10/h1-6H,(H,16,18)(H,13,14,17)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176793
PNG
(US9675612, 31 [7-(1H-Indazol-5-ylamino)[1,3]thiazo...)
Show SMILES O=C(N1CCCCC1)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C18H17N7OS/c26-18(25-6-2-1-3-7-25)17-23-14-15(19-10-20-16(14)27-17)22-12-4-5-13-11(8-12)9-21-24-13/h4-5,8-10H,1-3,6-7H2,(H,21,24)(H,19,20,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176747
PNG
(US9675612, 3 6-[(2-Cyclohexyl[1,3]thiazolo[5,4-d]p...)
Show SMILES O=c1[nH]c2ccc(Nc3ncnc4sc(nc34)C3CCCCC3)cc2s1
Show InChI InChI=1S/C18H17N5OS2/c24-18-22-12-7-6-11(8-13(12)25-18)21-15-14-17(20-9-19-15)26-16(23-14)10-4-2-1-3-5-10/h6-10H,1-5H2,(H,22,24)(H,19,20,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176790
PNG
(US9675612, 29 7-[(6-Methoxy-1H-indazol-5-yl)amino]...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C
Show InChI InChI=1S/C16H15N7O2S/c1-23(2)16(24)15-21-12-13(17-7-18-14(12)26-15)20-10-4-8-6-19-22-9(8)5-11(10)25-3/h4-7H,1-3H3,(H,19,22)(H,17,18,20)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176806
PNG
(US9675612, 43 7-(1H-Indazol-5-ylamino)-N,N-dimethy...)
Show SMILES CN(C)C(=O)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C15H13N7OS/c1-22(2)15(23)14-20-11-12(16-7-17-13(11)24-14)19-9-3-4-10-8(5-9)6-18-21-10/h3-7H,1-2H3,(H,18,21)(H,16,17,19)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176774
PNG
(US9675612, 17 2-(2-Phenylethyl)-N-[6-(propan-2-ylo...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(CCc3ccccc3)nc12
Show InChI InChI=1S/C23H22N6OS/c1-14(2)30-19-11-17-16(12-26-29-17)10-18(19)27-22-21-23(25-13-24-22)31-20(28-21)9-8-15-6-4-3-5-7-15/h3-7,10-14H,8-9H2,1-2H3,(H,26,29)(H,24,25,27)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176757
PNG
(US9675612, 7 6-[(2-Cyclohexyl[1,3]thiazolo[5,4-d]p...)
Show SMILES COc1cc2[nH]c(=O)sc2cc1Nc1ncnc2sc(nc12)C1CCCCC1
Show InChI InChI=1S/C19H19N5O2S2/c1-26-13-7-12-14(27-19(25)23-12)8-11(13)22-16-15-18(21-9-20-16)28-17(24-15)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,23,25)(H,20,21,22)
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n/an/a 354n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176784
PNG
(US9675612, 27 N,N-Dimethyl-7-[(2-oxo-2,3-dihydro-1...)
Show SMILES CN(C)C(=O)c1nc2c(Nc3ccc4[nH]c(=O)sc4c3)ncnc2s1
Show InChI InChI=1S/C15H12N6O2S2/c1-21(2)14(22)13-20-10-11(16-6-17-12(10)25-13)18-7-3-4-8-9(5-7)24-15(23)19-8/h3-6H,1-2H3,(H,19,23)(H,16,17,18)
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n/an/a 408n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176800
PNG
(US9675612, 37 N-[2-(Dimethylamino)-2-oxoethyl]-N-m...)
Show SMILES CN(C)C(=O)CN(C)C(=O)c1nc2c(Nc3ccc4[nH]c(=O)sc4c3)ncnc2s1
Show InChI InChI=1S/C18H17N7O3S2/c1-24(2)12(26)7-25(3)17(27)16-23-13-14(19-8-20-15(13)30-16)21-9-4-5-10-11(6-9)29-18(28)22-10/h4-6,8H,7H2,1-3H3,(H,22,28)(H,19,20,21)
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n/an/a 445n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176785
PNG
(US9675612, 28 7-[(5-Methoxy-2-oxo-2,3-dihydro-1,3-...)
Show SMILES COc1cc2[nH]c(=O)sc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C
Show InChI InChI=1S/C16H14N6O3S2/c1-22(2)15(23)14-21-11-12(17-6-18-13(11)27-14)19-7-5-10-8(4-9(7)25-3)20-16(24)26-10/h4-6H,1-3H3,(H,20,24)(H,17,18,19)
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n/an/a 1.08E+3n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176804
PNG
(US9675612, 41 N-[3-(Dimethylamino)-3-oxopropyl]-N-...)
Show SMILES CN(C)C(=O)CCN(C)C(=O)c1nc2c(Nc3ccc4[nH]c(=O)sc4c3)ncnc2s1
Show InChI InChI=1S/C19H19N7O3S2/c1-25(2)13(27)6-7-26(3)18(28)17-24-14-15(20-9-21-16(14)31-17)22-10-4-5-11-12(8-10)30-19(29)23-11/h4-5,8-9H,6-7H2,1-3H3,(H,23,29)(H,20,21,22)
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n/an/a 2.75E+3n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM176782
PNG
(US9675612, 25 5-Methoxy-6-{[2-(2-phenylethyl)[1,3]...)
Show SMILES COc1cc2[nH]c(=O)sc2cc1Nc1ncnc2sc(CCc3ccccc3)nc12
Show InChI InChI=1S/C21H17N5O2S2/c1-28-15-9-14-16(29-21(27)25-14)10-13(15)24-19-18-20(23-11-22-19)30-17(26-18)8-7-12-5-3-2-4-6-12/h2-6,9-11H,7-8H2,1H3,(H,25,27)(H,22,23,24)
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n/an/a 1.00E+4n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%