BindingDB logo
myBDB logout

Patent code US9682141

Compile Data Set for Download or QSAR

Found 2516 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM130246
PNG
(US11547697, Compound 266 | US9682141, 266)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CC(C3)N3CCOCC3)n2c1
Show InChI InChI=1S/C22H22N6O3/c23-22-25-17-9-14(1-3-19(17)31-22)15-2-4-20-24-10-18(28(20)11-15)21(29)27-12-16(13-27)26-5-7-30-8-6-26/h1-4,9-11,16H,5-8,12-13H2,(H2,23,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM142043
PNG
(US9682141, 561)
Show SMILES CC(C)N1CCN(CC1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H23N7O/c1-13(2)27-7-9-28(10-8-27)19-12-23-16-5-4-15(24-20(16)26-19)14-3-6-18-17(11-14)25-21(22)29-18/h3-6,11-13H,7-10H2,1-2H3,(H2,22,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM142736
PNG
(US9682141, 569 | US9682141, 572)
Show SMILES CC(C)(N)C(=O)N1CCN(CC1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C22H24N8O2/c1-22(2,24)20(31)30-9-7-29(8-10-30)18-12-25-15-5-4-14(26-19(15)28-18)13-3-6-17-16(11-13)27-21(23)32-17/h3-6,11-12H,7-10,24H2,1-2H3,(H2,23,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM135638
PNG
(US11547697, Compound 283 | US9682141, 283)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)C1CN(C1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1 |r|
Show InChI InChI=1S/C47H63N15O9/c1-26-41(66)59-36(20-29-23-54-32-14-7-6-13-31(29)32)44(69)58-33(40(48)65)15-8-9-17-52-39(64)22-38(62-42(67)34(57-27(2)63)16-10-18-53-47(49)50)46(71)61-37(21-30-24-51-25-55-30)45(70)60-35(43(68)56-26)19-28-11-4-3-5-12-28/h3-7,11-14,23-26,33-38,54H,8-10,15-22H2,1-2H3,(H2,48,65)(H,51,55)(H,52,64)(H,56,68)(H,57,63)(H,58,69)(H,59,66)(H,60,70)(H,61,71)(H,62,67)(H4,49,50,53)/t26-,33-,34-,35+,36-,37-,38-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM142987
PNG
(US9682141, 576)
Show SMILES C[C@H]1CN(CCN1)c1cnc2ccc(nc2c1)-c1ccc2oc(N)nc2c1 |r|
Show InChI InChI=1S/C20H20N6O/c1-12-11-26(7-6-22-12)14-9-17-16(23-10-14)4-3-15(24-17)13-2-5-19-18(8-13)25-20(21)27-19/h2-5,8-10,12,22H,6-7,11H2,1H3,(H2,21,25)/t12-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM143032
PNG
(US9682141, 588)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(cc2n1)N1CC2CCC(C1)O2
Show InChI InChI=1S/C21H19N5O2/c22-21-25-19-7-12(1-6-20(19)28-21)16-4-5-17-18(24-16)8-13(9-23-17)26-10-14-2-3-15(11-26)27-14/h1,4-9,14-15H,2-3,10-11H2,(H2,22,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM143054
PNG
(US9682141, 594)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(cc2n1)N1CC(C1)N1CCN(CCO)CC1
Show InChI InChI=1S/C24H27N7O2/c25-24-28-22-11-16(1-4-23(22)33-24)19-2-3-20-21(27-19)12-17(13-26-20)31-14-18(15-31)30-7-5-29(6-8-30)9-10-32/h1-4,11-13,18,32H,5-10,14-15H2,(H2,25,28)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM143075
PNG
(US9682141, 600 | US9682141, 603)
Show SMILES CN1CCN(CC1)C1CN(C1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C22H24N8O/c1-28-6-8-29(9-7-28)15-12-30(13-15)20-11-24-17-4-3-16(25-21(17)27-20)14-2-5-19-18(10-14)26-22(23)31-19/h2-5,10-11,15H,6-9,12-13H2,1H3,(H2,23,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM136088
PNG
(US11547697, Compound 313 | US9682141, 313)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2c1)N1CC(C1)N1CCN(CC1)C1CC1
Show InChI InChI=1S/C33H53P/c1-19(2)26-17-27(20(3)4)30(28(18-26)21(5)6)29-24(9)22(7)23(8)25(10)31(29)34(32(11,12)13)33(14,15)16/h17-21H,1-16H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM143099
PNG
(US9682141, 607 | US9682141, 608)
Show SMILES CN1CC2CN(CC2C1)c1cnc2ccc(nc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H21N7O/c1-27-8-13-10-28(11-14(13)9-27)19-7-23-16-4-3-15(24-20(16)26-19)12-2-5-18-17(6-12)25-21(22)29-18/h2-7,13-14H,8-11H2,1H3,(H2,22,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM136746
PNG
(US11547697, Compound 329 | US9682141, 329)
Show SMILES CCN1CCN(CC1)C1CN(C1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C20H22O2/c1-22-17-8-10-20(11-9-17)13-16-7-6-15(5-4-14-2-3-14)12-18(16)19(20)21/h6-7,12,14,17H,2-3,8-11,13H2,1H3/t17-,20-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM136755
PNG
(US11547697, Compound 333 | US9682141, 333)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2c1)N1CC(C1)N1CCN(CCO)CC1
Show InChI InChI=1S/C23H35NO3S/c1-16(2)15-27-19-8-7-17-14-23(11-9-18(26-6)10-12-23)21(20(17)13-19)24-28(25)22(3,4)5/h7-8,13,16,18H,9-12,14-15H2,1-6H3/t18-,23-,28?
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM136759
PNG
(US11547697, Compound 337 | US9682141, 337)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2c1)N1CCC(CC1)n1cccn1
Show InChI InChI=1S/C18H22F3NO2/c1-23-13-4-6-17(7-5-13)11-12-2-3-14(10-15(12)16(17)22)24-9-8-18(19,20)21/h2-3,10,13,22H,4-9,11H2,1H3/t13-,17-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM136762
PNG
(US11547697, Compound 339 | US9682141, 339)
Show SMILES Cc1cn(cn1)C1CN(C1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C22H32FNO3S/c1-21(2,3)28(25)24-20-19-14-18(27-13-5-12-23)7-6-16(19)15-22(20)10-8-17(26-4)9-11-22/h6-7,14,17H,5,8-13,15H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM136780
PNG
(US11547697, Compound 348 | US9682141, 348)
Show SMILES Nc1nc2cc(ccc2o1)-c1nc(N2CCOCC2)c2cnn(C3CCNCC3)c2n1
Show InChI InChI=1S/C17H20F2N4/c1-10-14(21)23-17(22-10)13-8-12(20)3-2-11(13)9-15(17)4-6-16(18,19)7-5-15/h2-3,8H,4-7,9,20H2,1H3,(H2,21,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM136784
PNG
(US11547697, Compound 350 | US9682141, 350)
Show SMILES C[C@H]1CN(CCN1)C1CN(C1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1 |r|
Show InChI InChI=1S/C14H16BrNO2/c1-17-10-4-6-14(7-5-10)13(16)11-8-9(15)2-3-12(11)18-14/h2-3,8,10,16H,4-7H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM136804
PNG
(US11547697, Compound 356 | US9682141, 356)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccn2ncc(-c3ccncc3)c2c1
Show InChI InChI=1S/C20H28BrNO3S/c1-19(2,3)26(23)22-16-11-18(13-8-9-24-20(4,5)12-13)25-17-7-6-14(21)10-15(16)17/h6-7,10,13,18H,8-9,11-12H2,1-5H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM120858
PNG
(US11547697, Compound 72 | US9682141, 72)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(=O)[nH]c2c1
Show InChI InChI=1S/C15H10N4O2/c16-15-19-12-6-9(2-4-13(12)21-15)8-1-3-10-11(5-8)18-14(20)7-17-10/h1-7H,(H2,16,19)(H,18,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM127057
PNG
(US11547697, Compound 186 | US9682141, 186)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CCCC3)n2c1
Show InChI InChI=1S/C19H17N5O2/c20-19-22-14-9-12(3-5-16(14)26-19)13-4-6-17-21-10-15(24(17)11-13)18(25)23-7-1-2-8-23/h3-6,9-11H,1-2,7-8H2,(H2,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM142747
PNG
(US9682141, 570 | US9682141, 571)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2n1)N1CCN(CC1)C(=O)C1(N)CC1
Show InChI InChI=1S/C22H22N8O2/c23-21-27-16-11-13(1-4-17(16)32-21)14-2-3-15-19(26-14)28-18(12-25-15)29-7-9-30(10-8-29)20(31)22(24)5-6-22/h1-4,11-12H,5-10,24H2,(H2,23,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM119523
PNG
(US11547697, Compound 46 | US9682141, 46)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C#N)c(-c3ccncc3)c2c1
Show InChI InChI=1S/C22H13N5O/c23-11-16-12-26-18-3-1-14(9-17(18)21(16)13-5-7-25-8-6-13)15-2-4-20-19(10-15)27-22(24)28-20/h1-10,12H,(H2,24,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM124947
PNG
(US9682141, 121 | US9682141, 225)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2c1)N1CCN(CC1)C(=O)C1CCCN1
Show InChI InChI=1S/C24H25N7O2/c25-24-29-20-13-16(4-6-21(20)33-24)15-3-5-17-19(12-15)28-22(14-27-17)30-8-10-31(11-9-30)23(32)18-2-1-7-26-18/h3-6,12-14,18,26H,1-2,7-11H2,(H2,25,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM141227
PNG
(US9682141, 542)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2n1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C19H16F2N6O/c20-19(21)5-7-27(8-6-19)16-10-23-13-3-2-12(24-17(13)26-16)11-1-4-15-14(9-11)25-18(22)28-15/h1-4,9-10H,5-8H2,(H2,22,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM141977
PNG
(US9682141, 548 | US9682141, 552)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2n1)N1C2CCC1COC2
Show InChI InChI=1S/C20H18N6O2/c21-20-24-16-7-11(1-6-17(16)28-20)14-4-5-15-19(23-14)25-18(8-22-15)26-12-2-3-13(26)10-27-9-12/h1,4-8,12-13H,2-3,9-10H2,(H2,21,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM129818
PNG
(US11547697, Compound 250 | US9682141, 250)
Show SMILES CC(=O)Nc1nc2cc(ccc2s1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C16H12N4O2S/c1-8(21)18-16-20-12-7-10(3-5-14(12)23-16)9-2-4-13-11(6-9)19-15(17)22-13/h2-7H,1H3,(H2,17,19)(H,18,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM119522
PNG
(US11547697, Compound 45 | US9682141, 45)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)NCCN3CCOCC3)n2c1
Show InChI InChI=1S/C21H22N6O3/c22-21-25-16-11-14(1-3-18(16)30-21)15-2-4-19-24-12-17(27(19)13-15)20(28)23-5-6-26-7-9-29-10-8-26/h1-4,11-13H,5-10H2,(H2,22,25)(H,23,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM119526
PNG
(US11547697, Compound 49 | US9682141, 49)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(OC3CCOCC3)nc2c1
Show InChI InChI=1S/C20H18N4O3/c21-20-24-17-10-13(2-4-18(17)27-20)12-1-3-15-16(9-12)23-19(11-22-15)26-14-5-7-25-8-6-14/h1-4,9-11,14H,5-8H2,(H2,21,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM119528
PNG
(US9682141, 51)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(-c3ccc(nc3)N3CCOCC3)n2c1
Show InChI InChI=1S/C23H20N6O2/c24-23-27-18-11-15(1-4-20(18)31-23)17-3-6-22-26-13-19(29(22)14-17)16-2-5-21(25-12-16)28-7-9-30-10-8-28/h1-6,11-14H,7-10H2,(H2,24,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM136841
PNG
(US11547697, Compound 368 | US9682141, 368)
Show SMILES Cc1cc(cc2c(cnn12)C(=O)N1CCCC1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C23H30BrN3O3/c1-14-19(25-20(28)30-21(2,3)4)27-23(26-14)18-12-16(24)7-6-15(18)13-22(23)10-8-17(29-5)9-11-22/h6-7,12,17H,8-11,13H2,1-5H3,(H,25,27,28)/t17-,22-,23?
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM136881
PNG
(US11547697, Compound 373 | US9682141, 373)
Show SMILES Nc1nc2cc(c(F)cc2o1)-c1ccc2ncc(nc2c1)N1CC(C1)N1CCOCC1
Show InChI InChI=1S/C20H26BrNO3S/c1-18(2,3)26(23)22-17-16-12-15(21)5-4-14(16)13-19(17)6-8-20(9-7-19)24-10-11-25-20/h4-5,12H,6-11,13H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM138086
PNG
(US11547697, Compound 395 | US9682141, 395)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2c1)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C24H25F3N2O4/c1-22(2,13-31)14-33-16-9-18(15-11-28-29(12-15)7-8-30)21-17-5-3-4-6-19(17)23(32,20(21)10-16)24(25,26)27/h3-6,9-12,30-32H,7-8,13-14H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM138176
PNG
(US11547697, Compound 417 | US9682141, 417)
Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C12H13ClFN/c1-15-6-9-5-12(9,7-15)8-2-3-11(14)10(13)4-8/h2-4,9H,5-7H2,1H3/t9?,12-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM138177
PNG
(US11547697, Compound 418 | US9682141, 418)
Show SMILES CS(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C12H13ClFN/c1-15-6-9-5-12(9,7-15)8-2-3-11(14)10(13)4-8/h2-4,9H,5-7H2,1H3/t9?,12-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
The kinase reaction is performed in a white 384 well microtitre plate. The total reaction volume is 20 ul per well and the reaction buffer compositio...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM138177
PNG
(US11547697, Compound 418 | US9682141, 418)
Show SMILES CS(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C12H13ClFN/c1-15-6-9-5-12(9,7-15)8-2-3-11(14)10(13)4-8/h2-4,9H,5-7H2,1H3/t9?,12-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM138185
PNG
(US11547697, Compound 423 | US9682141, 423)
Show SMILES COc1ncc(cc1NS(=O)(=O)c1cccc(F)c1)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C13H16FN/c1-9-3-4-10(5-12(9)14)13-6-11(13)7-15(2)8-13/h3-5,11H,6-8H2,1-2H3/t11?,13-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM138189
PNG
(US11547697, Compound 425 | US9682141, 425)
Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)Nc1cncc(c1)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C16H17N/c1-17-10-13-9-16(13,11-17)15-8-4-6-12-5-2-3-7-14(12)15/h2-8,13H,9-11H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM138316
PNG
(US11547697, Compound 436 | US9682141, 436)
Show SMILES Nc1nc2cc(cc(F)c2o1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C21H22BrN3O2/c22-18-7-2-1-4-14(18)12-24-10-8-16(9-11-24)25-13-15-5-3-6-17(20(23)26)19(15)21(25)27/h1-7,16H,8-13H2,(H2,23,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM139751
PNG
(US11547697, Compound 457 | US9682141, 457)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C19H27N5O3/c1-26-17-15(27-12-13(25)11-23-8-3-2-4-9-23)6-5-14-16(17)22-19(20)24-10-7-21-18(14)24/h5-6,13,25H,2-4,7-12H2,1H3,(H2,20,22)/t13-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM139751
PNG
(US11547697, Compound 457 | US9682141, 457)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C19H27N5O3/c1-26-17-15(27-12-13(25)11-23-8-3-2-4-9-23)6-5-14-16(17)22-19(20)24-10-7-21-18(14)24/h5-6,13,25H,2-4,7-12H2,1H3,(H2,20,22)/t13-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM139751
PNG
(US11547697, Compound 457 | US9682141, 457)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncc(C(=O)N3CCOCC3)n2c1
Show InChI InChI=1S/C19H27N5O3/c1-26-17-15(27-12-13(25)11-23-8-3-2-4-9-23)6-5-14-16(17)22-19(20)24-10-7-21-18(14)24/h5-6,13,25H,2-4,7-12H2,1H3,(H2,20,22)/t13-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM126957
PNG
(US11547697, Compound 174 | US9682141, 174)
Show SMILES Cc1nccn1-c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C19H14N6O/c1-11-21-6-7-25(11)18-10-22-14-4-2-12(8-15(14)23-18)13-3-5-17-16(9-13)24-19(20)26-17/h2-10H,1H3,(H2,20,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM126957
PNG
(US11547697, Compound 174 | US9682141, 174)
Show SMILES Cc1nccn1-c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C19H14N6O/c1-11-21-6-7-25(11)18-10-22-14-4-2-12(8-15(14)23-18)13-3-5-17-16(9-13)24-19(20)26-17/h2-10H,1H3,(H2,20,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM127060
PNG
(US11547697, Compound 187 | US9682141, 187)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)NC3CC3)n2c1
Show InChI InChI=1S/C18H15N5O2/c19-18-22-13-7-10(1-5-15(13)25-18)11-2-6-16-20-8-14(23(16)9-11)17(24)21-12-3-4-12/h1-2,5-9,12H,3-4H2,(H2,19,22)(H,21,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM127065
PNG
(US11547697, Compound 189 | US9682141, 189)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)NCCO)n2c1
Show InChI InChI=1S/C17H15N5O3/c18-17-21-12-7-10(1-3-14(12)25-17)11-2-4-15-20-8-13(22(15)9-11)16(24)19-5-6-23/h1-4,7-9,23H,5-6H2,(H2,18,21)(H,19,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM127070
PNG
(US11547697, Compound 192 | US9682141, 192)
Show SMILES NCC(=O)N1CCN(CC1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H21N7O2/c22-11-20(29)28-7-5-27(6-8-28)19-12-24-15-3-1-13(9-16(15)25-19)14-2-4-18-17(10-14)26-21(23)30-18/h1-4,9-10,12H,5-8,11,22H2,(H2,23,26)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM127075
PNG
(US11547697, Compound 193 | US9682141, 193)
Show SMILES COC(=O)N1CCN(CC1)c1cnc2ccc(cc2n1)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H20N6O3/c1-29-21(28)27-8-6-26(7-9-27)19-12-23-15-4-2-13(10-16(15)24-19)14-3-5-18-17(11-14)25-20(22)30-18/h2-5,10-12H,6-9H2,1H3,(H2,22,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM127392
PNG
(US11547697, Compound 197 | US9682141, 197)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(C(=O)N3CCC3)n2c1
Show InChI InChI=1S/C18H15N5O2/c19-18-21-13-8-11(2-4-15(13)25-18)12-3-5-16-20-9-14(23(16)10-12)17(24)22-6-1-7-22/h2-5,8-10H,1,6-7H2,(H2,19,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))		BDBM127476
PNG
(US11547697, Compound 206 | US9682141, 206)
Show SMILES CC(C)n1cnc2ccc(cc2c1=O)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C18H16N4O2/c1-10(2)22-9-20-14-5-3-11(7-13(14)17(22)23)12-4-6-16-15(8-12)21-18(19)24-16/h3-10H,1-2H3,(H2,19,21)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))		BDBM127507
PNG
(US11547697, Compound 209 | US9682141, 209)
Show SMILES Nc1nc2cc(ccc2o1)-c1ccc2ncc(nc2c1)N1CCC(O)C1
Show InChI InChI=1S/C19H17N5O2/c20-19-23-16-8-12(2-4-17(16)26-19)11-1-3-14-15(7-11)22-18(9-21-14)24-6-5-13(25)10-24/h1-4,7-9,13,25H,5-6,10H2,(H2,20,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))		BDBM127518
PNG
(US11547697, Compound 211 | US9682141, 211)
Show SMILES CC(=O)N1CCC(CC1)Nc1ncnc2ccc(nc12)-c1ccc2oc(N)nc2c1
Show InChI InChI=1S/C21H21N7O2/c1-12(29)28-8-6-14(7-9-28)25-20-19-16(23-11-24-20)4-3-15(26-19)13-2-5-18-17(10-13)27-21(22)30-18/h2-5,10-11,14H,6-9H2,1H3,(H2,22,27)(H,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/a25



Intellikine LLC

US Patent


Assay Description
Briefly, the assay is a time resolved FRET assay that indirectly measures PIP3 product formed by the activity of a PI3-K. The kinase reaction is perf...

US Patent US9682141 (2017)


BindingDB Entry DOI: 10.7270/Q2GF0RPH
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 2516 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%