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Patent code US9682965

Compile Data Set for Download or QSAR
Found 75 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152686
PNG
(US9682965, 121)
Show SMILES [#6]-[#6]-[#7]-[#6]-[#6]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6] |r|
Show InChI InChI=1S/C24H40N2O5/c1-6-25-12-10-17-13-26(14-17)22(27)30-18-9-11-24(15-29-24)21(20(18)28-5)23(4)19(31-23)8-7-16(2)3/h7,17-21,25H,6,8-15H2,1-5H3/t18-,19-,20-,21-,23+,24+/m1/s1
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n/an/a<50n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148457
PNG
(US10023561, Example 16 | US9682965, 16)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]C3([#6]-[#8]-[#6]3)[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C27H42N2O6/c1-18(2)5-6-21-25(3,35-21)23-22(31-4)20(7-9-27(23)17-33-27)34-24(30)29-11-19(12-29)8-10-28-13-26(14-28)15-32-16-26/h5,19-23H,6-17H2,1-4H3/t20-,21-,22-,23-,25+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152573
PNG
(US10023561, Example 62 | US9682965, 62)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]-[#8]-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C26H40N2O7/c1-17(2)5-6-20-25(3,35-20)23-22(31-4)19(7-8-26(23)16-33-26)34-24(30)28-14-18(15-28)13-21(29)27-9-11-32-12-10-27/h5,18-20,22-23H,6-16H2,1-4H3/t19-,20-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152576
PNG
(US10023561, Example 66 | US9682965, 66)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C28H47N3O6/c1-7-30(8-2)14-13-29-23(32)15-20-16-31(17-20)26(33)36-21-11-12-28(18-35-28)25(24(21)34-6)27(5)22(37-27)10-9-19(3)4/h9,20-22,24-25H,7-8,10-18H2,1-6H3,(H,29,32)/t21-,22-,24-,25-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM150800
PNG
(US10023561, Example 53 | US9682965, 53)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#6@H]-1-[#6]-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)15-12-20-13-16-29(17-20)25(30)33-21-11-14-27(18-32-27)24(23(21)31-6)26(5)22(34-26)10-9-19(3)4/h9,20-24H,7-8,10-18H2,1-6H3/t20-,21+,22+,23+,24+,26-,27-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148472
PNG
(US10023561, Example 22 | US9682965, 22)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]3-[#6](-[#6]-2)C3(F)F)-[#6]-1 |r|
Show InChI InChI=1S/C27H40F2N2O5/c1-16(2)5-6-21-25(3,36-21)23-22(33-4)20(7-9-26(23)15-34-26)35-24(32)31-11-17(12-31)8-10-30-13-18-19(14-30)27(18,28)29/h5,17-23H,6-15H2,1-4H3/t18?,19?,20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152664
PNG
(US10023561, Example 84 | US9682965, 84)
Show SMILES [#6]-[#7]-[#6](=O)-[#7]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C22H35N3O6/c1-13(2)6-7-16-21(3,31-16)18-17(28-5)15(8-9-22(18)12-29-22)30-20(27)25-10-14(11-25)24-19(26)23-4/h6,14-18H,7-12H2,1-5H3,(H2,23,24,26)/t15-,16-,17-,18-,21+,22+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148444
PNG
(US10023561, Example 5 | US9682965, 5)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C25H40N2O5/c1-17(2)6-7-20-24(3,32-20)22-21(29-4)19(8-10-25(22)16-30-25)31-23(28)27-14-18(15-27)9-13-26-11-5-12-26/h6,18-22H,5,7-16H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152578
PNG
(US10023561, Example 68 | US9682965, 68)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#7]-[#6](=O)-[#8]-[#6]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C28H47N3O7/c1-7-30(8-2)14-13-29-25(32)35-17-20-15-31(16-20)26(33)37-21-11-12-28(18-36-28)24(23(21)34-6)27(5)22(38-27)10-9-19(3)4/h9,20-24H,7-8,10-18H2,1-6H3,(H,29,32)/t21-,22-,23-,24-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM150755
PNG
(US10023561, Example 49 | US9682965, 49)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]C1([#8])[#6]-[#7](-[#6]1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C26H44N2O6/c1-7-27(8-2)14-13-25(30)15-28(16-25)23(29)33-19-11-12-26(17-32-26)22(21(19)31-6)24(5)20(34-24)10-9-18(3)4/h9,19-22,30H,7-8,10-17H2,1-6H3/t19-,20-,21-,22-,24+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152575
PNG
(US10023561, Example 65 | US9682965, 65)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6](-[#7])=O)-[#6]-1 |r|
Show InChI InChI=1S/C22H34N2O6/c1-13(2)5-6-16-21(3,30-16)19-18(27-4)15(7-8-22(19)12-28-22)29-20(26)24-10-14(11-24)9-17(23)25/h5,14-16,18-19H,6-12H2,1-4H3,(H2,23,25)/t15-,16-,18-,19-,21+,22+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152144
PNG
(US10023561, Example 54 | US9682965, 54)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]-[#6@H](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#8]-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C27H44N2O6/c1-19(2)5-6-22-26(3,35-22)24-23(31-4)21(7-10-27(24)18-33-27)34-25(30)29-12-9-20(17-29)8-11-28-13-15-32-16-14-28/h5,20-24H,6-18H2,1-4H3/t20-,21+,22+,23+,24+,26-,27-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148432
PNG
(US10023561, Example 1 | US9682965, 1)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#8]-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C26H42N2O6/c1-18(2)5-6-21-25(3,34-21)23-22(30-4)20(7-9-26(23)17-32-26)33-24(29)28-15-19(16-28)8-10-27-11-13-31-14-12-27/h5,19-23H,6-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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n/an/a<50n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148452
PNG
(US10023561, Example 9 | US9682965, 9)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]C([#6])([#8])[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C26H42N2O6/c1-17(2)6-7-20-25(4,34-20)22-21(31-5)19(8-10-26(22)16-32-26)33-23(29)28-12-18(13-28)9-11-27-14-24(3,30)15-27/h6,18-22,30H,7-16H2,1-5H3/t19-,20-,21-,22-,25+,26+/m1/s1
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n/an/a<50n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152758
PNG
(US10023561, Example 122 | US9682965, 122)
Show SMILES [#6]-[#6]-[#7]-[#6]-[#6@@H]-1-[#6]-[#6]-[#7]-1-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C23H38N2O5/c1-6-24-13-16-10-12-25(16)21(26)29-17-9-11-23(14-28-23)20(19(17)27-5)22(4)18(30-22)8-7-15(2)3/h7,16-20,24H,6,8-14H2,1-5H3/t16-,17+,18+,19+,20+,22-,23-/m0/s1
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n/an/a<50n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152582
PNG
(US10023561, Example 72 | US9682965, 72)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-1)-[#8]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C21H32N2O7/c1-12(2)5-6-15-20(3,30-15)17-16(26-4)14(7-8-21(17)11-27-21)29-19(25)23-9-13(10-23)28-18(22)24/h5,13-17H,6-11H2,1-4H3,(H2,22,24)/t14-,15-,16-,17-,20+,21+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152583
PNG
(US10023561, Example 73 | US9682965, 73)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#7]-[#6](=O)-[#8]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C27H45N3O7/c1-7-29(8-2)14-13-28-24(31)35-19-15-30(16-19)25(32)36-20-11-12-27(17-34-27)23(22(20)33-6)26(5)21(37-26)10-9-18(3)4/h9,19-23H,7-8,10-17H2,1-6H3,(H,28,31)/t20-,21-,22-,23-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148450
PNG
(US10023561, Example 7 | US9682965, 7)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6](-[#8])-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C27H44N2O6/c1-18(2)5-6-22-26(3,35-22)24-23(32-4)21(7-11-27(24)17-33-27)34-25(31)29-15-19(16-29)8-12-28-13-9-20(30)10-14-28/h5,19-24,30H,6-17H2,1-4H3/t21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152311
PNG
(US10023561, Example 59 | US9682965, 59)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C27H44N2O5/c1-19(2)9-10-22-26(3,34-22)24-23(31-4)21(11-12-27(24)18-32-27)33-25(30)29-16-20(17-29)8-7-15-28-13-5-6-14-28/h9,20-24H,5-8,10-18H2,1-4H3/t21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152571
PNG
(US10023561, Example 61 | US9682965, 61)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#6]C1([#8])[#6]-[#7](-[#6]1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C27H46N2O6/c1-7-28(8-2)15-9-13-26(31)16-29(17-26)24(30)34-20-12-14-27(18-33-27)23(22(20)32-6)25(5)21(35-25)11-10-19(3)4/h10,20-23,31H,7-9,11-18H2,1-6H3/t20-,21-,22-,23-,25+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152574
PNG
(US10023561, Example 63 | US9682965, 63)
Show SMILES [#6]-[#7]-[#6](=O)-[#6]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C23H36N2O6/c1-14(2)6-7-17-22(3,31-17)20-19(28-5)16(8-9-23(20)13-29-23)30-21(27)25-11-15(12-25)10-18(26)24-4/h6,15-17,19-20H,7-13H2,1-5H3,(H,24,26)/t16-,17-,19-,20-,22+,23+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152147
PNG
(US10023561, Example 56 | US9682965, 56)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)15-12-20-13-16-29(17-20)25(30)33-21-11-14-27(18-32-27)24(23(21)31-6)26(5)22(34-26)10-9-19(3)4/h9,20-24H,7-8,10-18H2,1-6H3/t20-,21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152682
PNG
(US10023561, Example 103 | US9682965, 103)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C26H44N2O5/c1-7-27(8-2)14-12-19-15-28(16-19)24(29)32-20-11-13-26(17-31-26)23(22(20)30-6)25(5)21(33-25)10-9-18(3)4/h9,19-23H,7-8,10-17H2,1-6H3/t20-,21-,22-,23-,25+,26+/m1/s1
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n/an/a<50n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148451
PNG
(US10023561, Example 8 | US9682965, 8)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]C([#6])([#8])[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C28H46N2O6/c1-19(2)6-7-22-27(4,36-22)24-23(33-5)21(8-10-28(24)18-34-28)35-25(31)30-16-20(17-30)9-13-29-14-11-26(3,32)12-15-29/h6,20-24,32H,7-18H2,1-5H3/t21-,22-,23-,24-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148442
PNG
(US10023561, Example 4 | US9682965, 4)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C27H44N2O5/c1-19(2)8-9-22-26(3,34-22)24-23(31-4)21(10-12-27(24)18-32-27)33-25(30)29-16-20(17-29)11-15-28-13-6-5-7-14-28/h8,20-24H,5-7,9-18H2,1-4H3/t21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152584
PNG
(US10023561, Example 74 | US9682965, 74)
Show SMILES [#6]-[#7]-[#6](=O)-[#8]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C22H34N2O7/c1-13(2)6-7-16-21(3,31-16)18-17(27-5)15(8-9-22(18)12-28-22)30-20(26)24-10-14(11-24)29-19(25)23-4/h6,14-18H,7-12H2,1-5H3,(H,23,25)/t15-,16-,17-,18-,21+,22+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148449
PNG
(US10023561, Example 6 | US9682965, 6)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6](-[#8])-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C25H40N2O6/c1-16(2)5-6-20-24(3,33-20)22-21(30-4)19(7-9-25(22)15-31-25)32-23(29)27-11-17(12-27)8-10-26-13-18(28)14-26/h5,17-22,28H,6-15H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148438
PNG
(US10023561, Example 3 | US9682965, 3)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C26H42N2O5/c1-18(2)7-8-21-25(3,33-21)23-22(30-4)20(9-11-26(23)17-31-26)32-24(29)28-15-19(16-28)10-14-27-12-5-6-13-27/h7,19-23H,5-6,8-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM149586
PNG
(US10023561, Example 40 | US9682965, 40)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6@@H]-1-[#6]-[#6]-[#7]-1-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C25H42N2O5/c1-7-26(8-2)15-18-12-14-27(18)23(28)31-19-11-13-25(16-30-25)22(21(19)29-6)24(5)20(32-24)10-9-17(3)4/h9,18-22H,7-8,10-16H2,1-6H3/t18-,19+,20+,21+,22+,24-,25-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152760
PNG
(US10023561, Example 124 | US9682965, 124)
Show SMILES [#6]-[#6]-[#7]-[#6]-[#6]-[#6]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C25H42N2O5/c1-6-26-13-7-8-18-14-27(15-18)23(28)31-19-11-12-25(16-30-25)22(21(19)29-5)24(4)20(32-24)10-9-17(2)3/h9,18-22,26H,6-8,10-16H2,1-5H3/t19-,20-,21-,22-,24+,25+/m1/s1
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n/an/a<50n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152759
PNG
(US10023561, Example 123 | US9682965, 123)
Show SMILES [#6]-[#6]-[#7]-[#6]-[#6@H]-1-[#6]-[#6]-[#7]-1-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C23H38N2O5/c1-6-24-13-16-10-12-25(16)21(26)29-17-9-11-23(14-28-23)20(19(17)27-5)22(4)18(30-22)8-7-15(2)3/h7,16-20,24H,6,8-14H2,1-5H3/t16-,17-,18-,19-,20-,22+,23+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152670
PNG
(US10023561, Example 88 | US9682965, 88)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C29H49N3O6/c1-7-31(8-2)16-15-30-24(33)12-10-21-17-32(18-21)27(34)37-22-13-14-29(19-36-29)26(25(22)35-6)28(5)23(38-28)11-9-20(3)4/h9,21-23,25-26H,7-8,10-19H2,1-6H3,(H,30,33)/t22-,23-,25-,26-,28+,29+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM150799
PNG
(US10023561, Example 52 | US9682965, 52)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#6]-1-[#6]-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)15-12-20-13-16-29(17-20)25(30)33-21-11-14-27(18-32-27)24(23(21)31-6)26(5)22(34-26)10-9-19(3)4/h9,20-24H,7-8,10-18H2,1-6H3/t20?,21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148455
PNG
(US10023561, Example 13 | US9682965, 13)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]C(F)(F)[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C27H42F2N2O5/c1-18(2)5-6-21-25(3,36-21)23-22(33-4)20(7-9-26(23)17-34-26)35-24(32)31-15-19(16-31)8-12-30-13-10-27(28,29)11-14-30/h5,19-23H,6-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152679
PNG
(US10023561, Example 98 | US9682965, 98)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-1)-[#7]-c1ccccn1 |r|
Show InChI InChI=1S/C25H35N3O5/c1-16(2)8-9-19-24(3,33-19)22-21(30-4)18(10-11-25(22)15-31-25)32-23(29)28-13-17(14-28)27-20-7-5-6-12-26-20/h5-8,12,17-19,21-22H,9-11,13-15H2,1-4H3,(H,26,27)/t18-,19-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148478
PNG
(US10023561, Example 37 | US9682965, 37)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]-[#6@@H](-[#6]-[#7]-2-[#6]-[#6]-[#8]-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C26H42N2O6/c1-18(2)5-6-21-25(3,34-21)23-22(30-4)20(7-9-26(23)17-32-26)33-24(29)28-10-8-19(16-28)15-27-11-13-31-14-12-27/h5,19-23H,6-17H2,1-4H3/t19-,20+,21+,22+,23+,25-,26-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152681
PNG
(US10023561, Example 101 | US9682965, 101)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-c2ccc(-[#6])nc2)-[#6]-1 |r|
Show InChI InChI=1S/C27H38N2O5/c1-17(2)6-9-22-26(4,34-22)24-23(31-5)21(10-11-27(24)16-32-27)33-25(30)29-14-20(15-29)12-19-8-7-18(3)28-13-19/h6-8,13,20-24H,9-12,14-16H2,1-5H3/t21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148477
PNG
(US10023561, Example 34 | US9682965, 34)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6](F)F)-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C28H45F2N3O5/c1-19(2)5-6-22-27(3,38-22)25-24(35-4)21(7-9-28(25)18-36-28)37-26(34)33-15-20(16-33)8-10-31-11-13-32(14-12-31)17-23(29)30/h5,20-25H,6-18H2,1-4H3/t21-,22-,24-,25-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152146
PNG
(US10023561, Example 55 | US9682965, 55)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]-[#6@@H](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#8]-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C27H44N2O6/c1-19(2)5-6-22-26(3,35-22)24-23(31-4)21(7-10-27(24)18-33-27)34-25(30)29-12-9-20(17-29)8-11-28-13-15-32-16-14-28/h5,20-24H,6-18H2,1-4H3/t20-,21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148456
PNG
(US10023561, Example 14 | US9682965, 14)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]C([#6])([#6]-2)C#N)-[#6]-1 |r|
Show InChI InChI=1S/C27H41N3O5/c1-18(2)6-7-21-26(4,35-21)23-22(32-5)20(8-10-27(23)17-33-27)34-24(31)30-12-19(13-30)9-11-29-15-25(3,14-28)16-29/h6,19-23H,7-13,15-17H2,1-5H3/t20-,21-,22-,23-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152683
PNG
(US10023561, Example 104 | US9682965, 104)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#6]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)15-9-10-20-16-29(17-20)25(30)33-21-13-14-27(18-32-27)24(23(21)31-6)26(5)22(34-26)12-11-19(3)4/h11,20-24H,7-10,12-18H2,1-6H3/t21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM150798
PNG
(US10023561, Example 51 | US9682965, 51)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)17-14-20-10-9-16-29(20)25(30)33-21-13-15-27(18-32-27)24(23(21)31-6)26(5)22(34-26)12-11-19(3)4/h11,20-24H,7-10,12-18H2,1-6H3/t20-,21+,22+,23+,24+,26-,27-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148971
PNG
(US10023561, Example 38 | US9682965, 38)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6@H]-1-[#6]-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C26H44N2O5/c1-7-27(8-2)15-19-12-14-28(16-19)24(29)32-20-11-13-26(17-31-26)23(22(20)30-6)25(5)21(33-25)10-9-18(3)4/h9,19-23H,7-8,10-17H2,1-6H3/t19-,20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152680
PNG
(US10023561, Example 100 | US9682965, 100)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-c2ccccn2)-[#6]-1 |r|
Show InChI InChI=1S/C26H36N2O5/c1-17(2)8-9-21-25(3,33-21)23-22(30-4)20(10-11-26(23)16-31-26)32-24(29)28-14-18(15-28)13-19-7-5-6-12-27-19/h5-8,12,18,20-23H,9-11,13-16H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM150748
PNG
(US10023561, Example 45 | US9682965, 45)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]C(F)(F)[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C26H40F2N2O5/c1-17(2)5-6-20-24(3,35-20)22-21(32-4)19(7-9-25(22)16-33-25)34-23(31)30-13-18(14-30)8-11-29-12-10-26(27,28)15-29/h5,18-22H,6-16H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
PDB
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152676
PNG
(US10023561, Example 91 | US9682965, 91)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#6]-2-[#6]-[#6]-[#7](-[#6]-[#6](F)F)-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C29H46F2N2O5/c1-19(2)5-8-23-28(3,38-23)26-25(35-4)22(9-12-29(26)18-36-29)37-27(34)33-15-21(16-33)7-6-20-10-13-32(14-11-20)17-24(30)31/h5,20-26H,6-18H2,1-4H3/t22-,23-,25-,26-,28+,29+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148454
PNG
(US10023561, Example 11 | US9682965, 11)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#7](-[#6])-[#6](=O)-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C27H43N3O6/c1-18(2)6-7-21-26(3,36-21)24-23(33-5)20(8-10-27(24)17-34-27)35-25(32)30-14-19(15-30)9-11-29-13-12-28(4)22(31)16-29/h6,19-21,23-24H,7-17H2,1-5H3/t20-,21-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148437
PNG
(US10023561, Example 2 | US9682965, 2)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]C(F)(F)[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C25H38F2N2O5/c1-16(2)5-6-19-23(3,34-19)21-20(31-4)18(7-9-24(21)15-32-24)33-22(30)29-11-17(12-29)8-10-28-13-25(26,27)14-28/h5,17-21H,6-15H2,1-4H3/t18-,19-,20-,21-,23+,24+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM150718
PNG
(US10023561, Example 44 | US9682965, 44)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-1-[#6]-[#7](-[#6]-[#6]-[#8]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C26H44N2O6/c1-7-27(8-2)15-19-16-28(13-14-31-19)24(29)33-20-11-12-26(17-32-26)23(22(20)30-6)25(5)21(34-25)10-9-18(3)4/h9,19-23H,7-8,10-17H2,1-6H3/t19?,20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152763
PNG
(US10023561, Example 127 | US9682965, 127)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CCC(C)C)OC(=O)N1CC(CCN2CCOCC2)C1 |r|
Show InChI InChI=1S/C26H44N2O6/c1-18(2)5-6-21-25(3,34-21)23-22(30-4)20(7-9-26(23)17-32-26)33-24(29)28-15-19(16-28)8-10-27-11-13-31-14-12-27/h18-23H,5-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152585
PNG
(US10023561, Example 78 | US9682965, 78)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-1)-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6])-[#6]-[#6]-1 |r|
Show InChI InChI=1S/C26H41N3O7/c1-17(2)6-7-20-25(3,36-20)22-21(32-5)19(8-9-26(22)16-33-26)35-24(31)29-14-18(15-29)34-23(30)28-12-10-27(4)11-13-28/h6,18-22H,7-16H2,1-5H3/t19-,20-,21-,22-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152685
PNG
(US10023561, Example 105 | US9682965, 105)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-1-[#6]-[#6]-[#7]-1-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C25H42N2O5/c1-7-26(8-2)15-18-12-14-27(18)23(28)31-19-11-13-25(16-30-25)22(21(19)29-6)24(5)20(32-24)10-9-17(3)4/h9,18-22H,7-8,10-16H2,1-6H3/t18?,19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM150542
PNG
(US10023561, Example 42 | US9682965, 42)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]-[#6@@H]-1-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-1 |r|
Show InChI InChI=1S/C25H40N2O5/c1-17(2)7-8-20-24(3,32-20)22-21(29-4)19(9-11-25(22)16-30-25)31-23(28)27-14-10-18(27)15-26-12-5-6-13-26/h7,18-22H,5-6,8-16H2,1-4H3/t18-,19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152191
PNG
(US10023561, Example 58 | US9682965, 58)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]-[#6@@H](-[#6]-[#6]-[#7]-2-[#6]C(F)(F)[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C26H40F2N2O5/c1-17(2)5-6-20-24(3,35-20)22-21(32-4)19(7-10-25(22)16-33-25)34-23(31)30-12-9-18(13-30)8-11-29-14-26(27,28)15-29/h5,18-22H,6-16H2,1-4H3/t18-,19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152659
PNG
(US10023561, Example 82 | US9682965, 82)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-1)-[#8]-[#6](=O)-[#7]-[#6]C([#6])([#6])[#8] |r|
Show InChI InChI=1S/C25H40N2O8/c1-15(2)7-8-18-24(5,35-18)20-19(31-6)17(9-10-25(20)14-32-25)34-22(29)27-11-16(12-27)33-21(28)26-13-23(3,4)30/h7,16-20,30H,8-14H2,1-6H3,(H,26,28)/t17-,18-,19-,20-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148475
PNG
(US10023561, Example 33 | US9682965, 33)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]-3-[#6]-[#6]-[#6](-[#6]-2)-[#8]-3)-[#6]-1 |r,THB:26:27:30.31:34|
Show InChI InChI=1S/C28H44N2O6/c1-18(2)5-8-23-27(3,36-23)25-24(32-4)22(9-11-28(25)17-33-28)35-26(31)30-13-19(14-30)10-12-29-15-20-6-7-21(16-29)34-20/h5,19-25H,6-17H2,1-4H3/t20?,21?,22-,23-,24-,25-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148474
PNG
(US10023561, Example 31 | US9682965, 31)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-3-[#6]-[#6]-[#6]-2-[#6]-[#8]-[#6]-3)-[#6]-1 |r,TLB:26:27:29.30:32.34.33|
Show InChI InChI=1S/C28H44N2O6/c1-18(2)5-8-23-27(3,36-23)25-24(32-4)22(9-11-28(25)17-34-28)35-26(31)29-13-19(14-29)10-12-30-20-6-7-21(30)16-33-15-20/h5,19-25H,6-17H2,1-4H3/t20?,21?,22-,23-,24-,25-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148465
PNG
(US10023561, Example 20 | US9682965, 20)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]C([#6])([#6]-2)[#6](=O)-[#7](-[#6])-[#6])-[#6]-1 |r|
Show InChI InChI=1S/C29H47N3O6/c1-19(2)8-9-22-28(4,38-22)24-23(35-7)21(10-12-29(24)18-36-29)37-26(34)32-14-20(15-32)11-13-31-16-27(3,17-31)25(33)30(5)6/h8,20-24H,9-18H2,1-7H3/t21-,22-,23-,24-,28+,29+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM150713
PNG
(US10023561, Example 43 | US9682965, 43)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6@H]-1-[#6]-[#6]-[#7]-1-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C25H42N2O5/c1-7-26(8-2)15-18-12-14-27(18)23(28)31-19-11-13-25(16-30-25)22(21(19)29-6)24(5)20(32-24)10-9-17(3)4/h9,18-22H,7-8,10-16H2,1-6H3/t18-,19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM149588
PNG
(US10023561, Example 41 | US9682965, 41)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]-[#6@H]-1-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-1 |r|
Show InChI InChI=1S/C25H40N2O5/c1-17(2)7-8-20-24(3,32-20)22-21(29-4)19(9-11-25(22)16-30-25)31-23(28)27-14-10-18(27)15-26-12-5-6-13-26/h7,18-22H,5-6,8-16H2,1-4H3/t18-,19+,20+,21+,22+,24-,25-/m0/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152677
PNG
(US10023561, Example 95 | US9682965, 95)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#7]-2-[#6]-[#6]-[#8]-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C25H40N2O6/c1-17(2)5-6-20-24(3,33-20)22-21(29-4)19(7-8-25(22)16-31-25)32-23(28)27-14-18(15-27)13-26-9-11-30-12-10-26/h5,18-22H,6-16H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152580
PNG
(US10023561, Example 69 | US9682965, 69)
Show SMILES [#6]-[#7]-[#6](=O)-[#8]-[#6]-[#6]-1-[#6]-[#7](-[#6]-1)-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C23H36N2O7/c1-14(2)6-7-17-22(3,32-17)19-18(28-5)16(8-9-23(19)13-30-23)31-21(27)25-10-15(11-25)12-29-20(26)24-4/h6,15-19H,7-13H2,1-5H3,(H,24,26)/t16-,17-,18-,19-,22+,23+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152675
PNG
(US10023561, Example 90 | US9682965, 90)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#6]-2-[#6]-[#6]-[#7](-[#6])-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C28H46N2O5/c1-19(2)6-9-23-27(3,35-23)25-24(32-5)22(10-13-28(25)18-33-28)34-26(31)30-16-21(17-30)8-7-20-11-14-29(4)15-12-20/h6,20-25H,7-18H2,1-5H3/t22-,23-,24-,25-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148458
PNG
(US10023561, Example 17 | US9682965, 17)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-n2cccn2)-[#6]-1 |r|
Show InChI InChI=1S/C25H37N3O5/c1-17(2)6-7-20-24(3,33-20)22-21(30-4)19(8-10-25(22)16-31-25)32-23(29)27-14-18(15-27)9-13-28-12-5-11-26-28/h5-6,11-12,18-22H,7-10,13-16H2,1-4H3/t19-,20-,21-,22-,24+,25+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148462
PNG
(US10023561, Example 19 | US9682965, 19)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6](-[#6]-2)-[#6](=O)-[#7](-[#6])-[#6])-[#6]-1 |r|
Show InChI InChI=1S/C28H45N3O6/c1-18(2)7-8-22-27(3,37-22)24-23(34-6)21(9-11-28(24)17-35-28)36-26(33)31-13-19(14-31)10-12-30-15-20(16-30)25(32)29(4)5/h7,19-24H,8-17H2,1-6H3/t21-,22-,23-,24-,27+,28+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152570
PNG
(US10023561, Example 60 | US9682965, 60)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C26H44N2O5/c1-7-27(8-2)16-19-10-9-15-28(19)24(29)32-20-13-14-26(17-31-26)23(22(20)30-6)25(5)21(33-25)12-11-18(3)4/h11,19-23H,7-10,12-17H2,1-6H3/t19-,20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM150750
PNG
(US10023561, Example 48 | US9682965, 48)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C26H44N2O5/c1-7-27(8-2)16-19-10-9-15-28(19)24(29)32-20-13-14-26(17-31-26)23(22(20)30-6)25(5)21(33-25)12-11-18(3)4/h11,19-23H,7-10,12-17H2,1-6H3/t19-,20+,21+,22+,23+,25-,26-/m0/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM150793
PNG
(US10023561, Example 50 | US9682965, 50)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6]-[#6]-[#6@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#8]-[#6@@H]-1-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H](-[#6@@H]-1-[#8]-[#6])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r|
Show InChI InChI=1S/C27H46N2O5/c1-7-28(8-2)17-14-20-10-9-16-29(20)25(30)33-21-13-15-27(18-32-27)24(23(21)31-6)26(5)22(34-26)12-11-19(3)4/h11,20-24H,7-10,12-18H2,1-6H3/t20-,21-,22-,23-,24-,26+,27+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152159
PNG
(US10023561, Example 57 | US9682965, 57)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]-[#6@H](-[#6]-[#6]-[#7]-2-[#6]C(F)(F)[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C26H40F2N2O5/c1-17(2)5-6-20-24(3,35-20)22-21(32-4)19(7-10-25(22)16-33-25)34-23(31)30-12-9-18(13-30)8-11-29-14-26(27,28)15-29/h5,18-22H,6-16H2,1-4H3/t18-,19+,20+,21+,22+,24-,25-/m0/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148453
PNG
(US10023561, Example 10 | US9682965, 10)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]S(=O)(=O)[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C26H42N2O7S/c1-18(2)5-6-21-25(3,35-21)23-22(32-4)20(7-9-26(23)17-33-26)34-24(29)28-15-19(16-28)8-10-27-11-13-36(30,31)14-12-27/h5,19-23H,6-17H2,1-4H3/t20-,21-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152658
PNG
(US10023561, Example 81 | US9682965, 81)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-1)-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6]C(F)(F)F)-[#6]-[#6]-1 |r|
Show InChI InChI=1S/C27H40F3N3O7/c1-17(2)5-6-20-25(3,40-20)22-21(36-4)19(7-8-26(22)16-37-26)39-24(35)33-13-18(14-33)38-23(34)32-11-9-31(10-12-32)15-27(28,29)30/h5,18-22H,6-16H2,1-4H3/t19-,20-,21-,22-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152577
PNG
(US10023561, Example 67 | US9682965, 67)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#8]-[#6]-[#6]-2)-[#6]-1 |r|
Show InChI InChI=1S/C29H47N3O7/c1-20(2)5-7-23-28(3,39-23)26-25(35-4)22(9-10-29(26)19-37-29)38-27(34)32-17-21(18-32)6-8-24(33)30-11-12-31-13-15-36-16-14-31/h5,21-23,25-26H,6-19H2,1-4H3,(H,30,33)/t22-,23-,25-,26-,28+,29+/m1/s1
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM148430
PNG
(US9682965, Compound A)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)\[#6]=[#6]\c1ccc(-[#8]-[#6]-[#6]-[#7](-[#6])-[#6])cc1
Show InChI InChI=1S/C29H41NO6/c1-20(2)7-13-24-28(3,36-24)27-26(32-6)23(15-16-29(27)19-34-29)35-25(31)14-10-21-8-11-22(12-9-21)33-18-17-30(4)5/h7-12,14,23-24,26-27H,13,15-19H2,1-6H3/b14-10+/t23-,24-,26-,27-,28+,29+/m1/s1
PDB
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n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM149584
PNG
(US10023561, Example 39 | US9682965, 39)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#8]-[#6]-[#6]-2=O)-[#6]-1 |r|
Show InChI InChI=1S/C26H40N2O7/c1-17(2)5-6-20-25(3,35-20)23-22(31-4)19(7-9-26(23)16-33-26)34-24(30)28-13-18(14-28)8-10-27-11-12-32-15-21(27)29/h5,18-20,22-23H,6-16H2,1-4H3/t19-,20-,22-,23-,25+,26+/m1/s1
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Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM152581
PNG
(US10023561, Example 71 | US9682965, 71)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-1-[#6]-[#6](-[#6]-1)-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]-[#8]-[#6]-[#6]-1 |r|
Show InChI InChI=1S/C25H38N2O8/c1-16(2)5-6-19-24(3,35-19)21-20(30-4)18(7-8-25(21)15-32-25)34-23(29)27-13-17(14-27)33-22(28)26-9-11-31-12-10-26/h5,17-21H,6-15H2,1-4H3/t18-,19-,20-,21-,24+,25+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 275n/an/an/an/a7.4n/a



Zafgen, Inc.

US Patent


Assay Description
Flag tagged Human recombinant MetAP2 expressed and isolated for use as the enzyme source. 10 mM stock solutions of compounds were prepared in 100% DM...

US Patent US9682965 (2017)


BindingDB Entry DOI: 10.7270/Q29S1P74
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%