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Patent code US9682976

Compile Data Set for Download or QSAR

Found 324 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-2


(Homo sapiens (Human))		BDBM160830
PNG
(US9682976, 2)
Show SMILES CC1(C)C[C@@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F |r|
Show InChI InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16-/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161073
PNG
(US9682976, 27 | US9682976, 29)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CCN5CCCC5C4)n3)c(F)cc2C2CC2)c1=O
Show InChI InChI=1S/C23H27F2N9O/c1-32-23(35)34(31-30-32)20-11-19(17(24)10-16(20)13-4-5-13)28-22-26-12-18(25)21(29-22)27-14-6-8-33-7-2-3-15(33)9-14/h10-15H,2-9H2,1H3,(H2,26,27,28,29)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161125
PNG
(US9682976, 43)
Show SMILES CC1(C)C[C@H](C[C@@H]2CC(F)(F)CN12)Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)ncc1F |r|
Show InChI InChI=1S/C24H27F4N9/c1-23(2)8-14(5-15-9-24(27,28)11-36(15)23)31-21-18(26)10-29-22(33-21)32-19-7-20(37-12-30-34-35-37)16(6-17(19)25)13-3-4-13/h6-7,10,12-15H,3-5,8-9,11H2,1-2H3,(H2,29,31,32,33)/t14-,15+/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161160
PNG
(US9682976, 46)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CC(F)(F)CN12)Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2cnnn2)ncc1F |r|
Show InChI InChI=1S/C24H27F4N9/c1-23(2)8-14(5-15-9-24(27,28)11-36(15)23)31-21-18(26)10-29-22(33-21)32-19-7-20(37-12-30-34-35-37)16(6-17(19)25)13-3-4-13/h6-7,10,12-15H,3-5,8-9,11H2,1-2H3,(H2,29,31,32,33)/t14-,15-/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161175
PNG
(US9682976, 61)
Show SMILES CC1(C)C[C@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc(O[C@@H]3CCOC3)c(c2)C#N)ncc1F |r|
Show InChI InChI=1S/C25H31FN6O2/c1-25(2)12-18(11-19-4-3-8-32(19)25)29-23-21(26)14-28-24(31-23)30-17-5-6-22(16(10-17)13-27)34-20-7-9-33-15-20/h5-6,10,14,18-20H,3-4,7-9,11-12,15H2,1-2H3,(H2,28,29,30,31)/t18-,19+,20+/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161417
PNG
(US9682976, 82)
Show SMILES C[C@@H](O)COc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C25H33F2N9O3/c1-14(37)13-39-21-9-17(26)19(10-20(21)36-24(38)34(4)32-33-36)30-23-28-12-18(27)22(31-23)29-15-8-16-6-5-7-35(16)25(2,3)11-15/h9-10,12,14-16,37H,5-8,11,13H2,1-4H3,(H2,28,29,30,31)/t14-,15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161428
PNG
(US9682976, 89)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2O)c1=O |r|
Show InChI InChI=1S/C22H27F2N9O2/c1-22(2)10-12(7-13-5-4-6-32(13)22)26-19-15(24)11-25-20(28-19)27-16-9-17(18(34)8-14(16)23)33-21(35)31(3)29-30-33/h8-9,11-13,34H,4-7,10H2,1-3H3,(H2,25,26,27,28)/t12-,13+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161690
PNG
(US9682976, 144)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cc(ccc2F)-n2nnnc2C2CC2)ncc1F |r|
Show InChI InChI=1S/C24H29F2N9/c1-24(2)12-15(10-16-4-3-9-34(16)24)28-21-19(26)13-27-23(30-21)29-20-11-17(7-8-18(20)25)35-22(14-5-6-14)31-32-33-35/h7-8,11,13-16H,3-6,9-10,12H2,1-2H3,(H2,27,28,29,30)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161700
PNG
(US9682976, 151)
Show SMILES COc1ccc(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnnc1C |r|
Show InChI InChI=1S/C23H30ClN9O/c1-14-29-30-31-33(14)19-11-15(7-8-20(19)34-4)27-22-25-13-18(24)21(28-22)26-16-10-17-6-5-9-32(17)23(2,3)12-16/h7-8,11,13,16-17H,5-6,9-10,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161713
PNG
(US9682976, 161)
Show SMILES COc1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(OC)c1 |r|
Show InChI InChI=1S/C22H30FN5O2/c1-22(2)12-15(8-16-6-5-7-28(16)22)25-20-19(23)13-24-21(27-20)26-14-9-17(29-3)11-18(10-14)30-4/h9-11,13,15-16H,5-8,12H2,1-4H3,(H2,24,25,26,27)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161719
PNG
(US9682976, 167)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC2CCO2)c1=O |r|
Show InChI InChI=1S/C26H33F2N9O3/c1-26(2)12-15(9-16-5-4-7-36(16)26)30-23-19(28)13-29-24(32-23)31-20-11-21(37-25(38)35(3)33-34-37)22(10-18(20)27)40-14-17-6-8-39-17/h10-11,13,15-17H,4-9,12,14H2,1-3H3,(H2,29,30,31,32)/t15-,16+,17?/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161722
PNG
(US9682976, 170 | US9682976, 187)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC2CCOCC2)c1=O |r|
Show InChI InChI=1S/C28H37F2N9O3/c1-28(2)14-18(11-19-5-4-8-38(19)28)32-25-21(30)15-31-26(34-25)33-22-13-23(39-27(40)37(3)35-36-39)24(12-20(22)29)42-16-17-6-9-41-10-7-17/h12-13,15,17-19H,4-11,14,16H2,1-3H3,(H2,31,32,33,34)/t18-,19+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161739
PNG
(US9682976, 184)
Show SMILES CCOC(=O)C(C)Oc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C27H35F2N9O4/c1-6-41-24(39)15(2)42-22-11-18(28)20(12-21(22)38-26(40)36(5)34-35-38)32-25-30-14-19(29)23(33-25)31-16-10-17-8-7-9-37(17)27(3,4)13-16/h11-12,14-17H,6-10,13H2,1-5H3,(H2,30,31,32,33)/t15?,16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161748
PNG
(US9682976, 190)
Show SMILES COCCOCCOc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C#N |r|
Show InChI InChI=1S/C26H35FN6O3/c1-26(2)15-20(14-21-5-4-8-33(21)26)30-24-22(27)17-29-25(32-24)31-19-6-7-23(18(13-19)16-28)36-12-11-35-10-9-34-3/h6-7,13,17,20-21H,4-5,8-12,14-15H2,1-3H3,(H2,29,30,31,32)/t20-,21+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161763
PNG
(US9682976, 201)
Show SMILES CC(O)COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C#N |r|
Show InChI InChI=1S/C24H31FN6O2/c1-15(32)14-33-21-7-6-17(9-16(21)12-26)29-23-27-13-20(25)22(30-23)28-18-10-19-5-4-8-31(19)24(2,3)11-18/h6-7,9,13,15,18-19,32H,4-5,8,10-11,14H2,1-3H3,(H2,27,28,29,30)/t15?,18-,19+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM168227
PNG
(US9682976, 240)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(Cl)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(C)(C)O)c1=O |r|
Show InChI InChI=1S/C26H35ClFN9O3/c1-25(2)12-15(9-16-7-6-8-36(16)25)30-22-17(27)13-29-23(32-22)31-19-11-20(37-24(38)35(5)33-34-37)21(10-18(19)28)40-14-26(3,4)39/h10-11,13,15-16,39H,6-9,12,14H2,1-5H3,(H2,29,30,31,32)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161807
PNG
(US9682976, 248)
Show SMILES Cn1nc2n(-c3cc(Nc4ncc(F)c(N[C@@H]5C[C@@H]6CCCN6C(C)(C)C5)n4)ccc3OC2(C)C)c1=O |r|
Show InChI InChI=1S/C26H33FN8O2/c1-25(2)13-16(11-17-7-6-10-34(17)25)29-21-18(27)14-28-23(31-21)30-15-8-9-20-19(12-15)35-22(26(3,4)37-20)32-33(5)24(35)36/h8-9,12,14,16-17H,6-7,10-11,13H2,1-5H3,(H2,28,29,30,31)/t16-,17+/m1/s1
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161826
PNG
(US9682976, 263)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2cccc(c2)-n2nnnc2SC(CO)CO)ncc1F |r|
Show InChI InChI=1S/C24H32FN9O2S/c1-24(2)11-16(10-17-7-4-8-33(17)24)27-21-20(25)12-26-22(29-21)28-15-5-3-6-18(9-15)34-23(30-31-32-34)37-19(13-35)14-36/h3,5-6,9,12,16-17,19,35-36H,4,7-8,10-11,13-14H2,1-2H3,(H2,26,27,28,29)/t16-,17+/m1/s1
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161858
PNG
(US9682976, 290)
Show SMILES COc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(CC(C)(C)O)c1=O |r|
Show InChI InChI=1S/C26H36FN9O3/c1-25(2)13-17(11-18-7-6-10-34(18)25)29-22-19(27)14-28-23(31-22)30-16-8-9-21(39-5)20(12-16)36-24(37)35(32-33-36)15-26(3,4)38/h8-9,12,14,17-18,38H,6-7,10-11,13,15H2,1-5H3,(H2,28,29,30,31)/t17-,18+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161903
PNG
(US9682976, 322 | US9682976, 323)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCC(N)=O)c1=O |r|
Show InChI InChI=1S/C24H30F2N10O3/c1-24(2)10-13(7-14-5-4-6-35(14)24)29-21-16(26)11-28-22(31-21)30-17-9-18(36-23(38)34(3)32-33-36)19(8-15(17)25)39-12-20(27)37/h8-9,11,13-14H,4-7,10,12H2,1-3H3,(H2,27,37)(H2,28,29,30,31)/t13-,14+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM160836
PNG
(US9682976, 7)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(N[C@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc1OC(F)F |r|
Show InChI InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)/t20-,21+/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM160839
PNG
(US9682976, 10)
Show SMILES CC(C)N1CCC(CC1)Oc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1OC(F)F |r|
Show InChI InChI=1S/C29H41F3N6O2/c1-18(2)37-12-9-22(10-13-37)39-24-8-7-19(15-25(24)40-27(31)32)35-28-33-17-23(30)26(36-28)34-20-14-21-6-5-11-38(21)29(3,4)16-20/h7-8,15,17-18,20-22,27H,5-6,9-14,16H2,1-4H3,(H2,33,34,35,36)/t20-,21+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM160840
PNG
(US9682976, 11)
Show SMILES COc1cc(Nc2ncc(F)c(N[C@H]3C[C@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C |r|
Show InChI InChI=1S/C23H30FN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161054
PNG
(US9682976, 20 | US9682976, 21)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O |r|
Show InChI InChI=1S/C25H31F2N9O/c1-25(2)12-15(9-16-5-4-8-35(16)25)29-22-19(27)13-28-23(31-22)30-20-11-21(36-24(37)34(3)32-33-36)17(10-18(20)26)14-6-7-14/h10-11,13-16H,4-9,12H2,1-3H3,(H2,28,29,30,31)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161159
PNG
(US9682976, 45)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CC(F)(F)CN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O |r|
Show InChI InChI=1S/C25H29F4N9O/c1-24(2)9-14(6-15-10-25(28,29)12-37(15)24)31-21-18(27)11-30-22(33-21)32-19-8-20(38-23(39)36(3)34-35-38)16(7-17(19)26)13-4-5-13/h7-8,11,13-15H,4-6,9-10,12H2,1-3H3,(H2,30,31,32,33)/t14-,15-/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161161
PNG
(US9682976, 47 | US9682976, 50)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)ccc2O[C@H]2CCOC2)c1=O |r|
Show InChI InChI=1S/C26H34FN9O3/c1-26(2)13-17(11-18-5-4-9-35(18)26)29-23-20(27)14-28-24(31-23)30-16-6-7-22(39-19-8-10-38-15-19)21(12-16)36-25(37)34(3)32-33-36/h6-7,12,14,17-19H,4-5,8-11,13,15H2,1-3H3,(H2,28,29,30,31)/t17-,18+,19+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161163
PNG
(US9682976, 49)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(NC4CC5CCCN5C(C)(C)C4)n3)ccc2O[C@@H]2CCOC2)c1=O |r|
Show InChI InChI=1S/C26H34FN9O3/c1-26(2)13-17(11-18-5-4-9-35(18)26)29-23-20(27)14-28-24(31-23)30-16-6-7-22(39-19-8-10-38-15-19)21(12-16)36-25(37)34(3)32-33-36/h6-7,12,14,17-19H,4-5,8-11,13,15H2,1-3H3,(H2,28,29,30,31)/t17?,18?,19-/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161179
PNG
(US9682976, 65)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@H]4C[C@@H]5C[C@H](F)CN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O |r|
Show InChI InChI=1S/C25H30F3N9O/c1-25(2)10-15(7-16-6-14(26)12-36(16)25)30-22-19(28)11-29-23(32-22)31-20-9-21(37-24(38)35(3)33-34-37)17(8-18(20)27)13-4-5-13/h8-9,11,13-16H,4-7,10,12H2,1-3H3,(H2,29,30,31,32)/t14-,15-,16-/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161180
PNG
(US9682976, 66)
Show SMILES Cn1nnn(-c2cc(Nc3ncc([N+]#[C-])c(N[C@H]4C[C@H]5CCCN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O |r|
Show InChI InChI=1S/C26H31FN10O/c1-26(2)13-16(10-17-6-5-9-36(17)26)30-23-21(28-3)14-29-24(32-23)31-20-12-22(37-25(38)35(4)33-34-37)18(11-19(20)27)15-7-8-15/h11-12,14-17H,5-10,13H2,1-2,4H3,(H2,29,30,31,32)/t16-,17+/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161181
PNG
(US9682976, 67)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5C[C@H](F)CN5C(C)(C)C4)n3)c(F)cc2C2CC2)c1=O |r|
Show InChI InChI=1S/C25H30F3N9O/c1-25(2)10-15(7-16-6-14(26)12-36(16)25)30-22-19(28)11-29-23(32-22)31-20-9-21(37-24(38)35(3)33-34-37)17(8-18(20)27)13-4-5-13/h8-9,11,13-16H,4-7,10,12H2,1-3H3,(H2,29,30,31,32)/t14-,15+,16-/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161398
PNG
(US9682976, 76)
Show SMILES CC1C2CCCN2C(C)(C)CC1Nc1nc(Nc2cc(c(cc2F)C2CC2)-n2nnn(C)c2=O)ncc1C#N
Show InChI InChI=1S/C27H33FN10O/c1-15-21(12-27(2,3)37-9-5-6-22(15)37)31-24-17(13-29)14-30-25(33-24)32-20-11-23(38-26(39)36(4)34-35-38)18(10-19(20)28)16-7-8-16/h10-11,14-16,21-22H,5-9,12H2,1-4H3,(H2,30,31,32,33)
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161454
PNG
(US9682976, 95)
Show SMILES CCc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C24H31F2N9O/c1-5-14-9-17(25)19(11-20(14)35-23(36)33(4)31-32-35)29-22-27-13-18(26)21(30-22)28-15-10-16-7-6-8-34(16)24(2,3)12-15/h9,11,13,15-16H,5-8,10,12H2,1-4H3,(H2,27,28,29,30)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161480
PNG
(US9682976, 101)
Show SMILES CC1(C)CC(C[C@@H]2CCCN12)Nc1nc(Nc2ccc(N3CC4(COC4)C3)c(c2)C#N)ncc1F |r|
Show InChI InChI=1S/C26H32FN7O/c1-25(2)10-19(9-20-4-3-7-34(20)25)30-23-21(27)12-29-24(32-23)31-18-5-6-22(17(8-18)11-28)33-13-26(14-33)15-35-16-26/h5-6,8,12,19-20H,3-4,7,9-10,13-16H2,1-2H3,(H2,29,30,31,32)/t19?,20-/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM160829
PNG
(US9682976, 1 | US9682976, 102)
Show SMILES CC1(C)C[C@H](C[C@H]2CCCN12)Nc1nc(Nc2ccc3OC(C)(C)c4nnnn4-c3c2)ncc1F |r|
Show InChI InChI=1S/C24H30FN9O/c1-23(2)12-15(10-16-6-5-9-33(16)23)27-20-17(25)13-26-22(29-20)28-14-7-8-19-18(11-14)34-21(30-31-32-34)24(3,4)35-19/h7-8,11,13,15-16H,5-6,9-10,12H2,1-4H3,(H2,26,27,28,29)/t15-,16+/m0/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161652
PNG
(US9682976, 111 | US9682976, 112)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2CCOC2)c1=O |r|
Show InChI InChI=1S/C27H33FN10O3/c1-27(2)12-17(9-18-5-4-7-37(18)27)31-24-16(13-29)14-30-25(33-24)32-21-11-22(38-26(39)36(3)34-35-38)23(10-20(21)28)41-19-6-8-40-15-19/h10-11,14,17-19H,4-9,12,15H2,1-3H3,(H2,30,31,32,33)/t17-,18+,19?/m1/s1
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161654
PNG
(US9682976, 113)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(C#N)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OC2COC2)c1=O |r|
Show InChI InChI=1S/C26H31FN10O3/c1-26(2)10-16(7-17-5-4-6-36(17)26)30-23-15(11-28)12-29-24(32-23)31-20-9-21(37-25(38)35(3)33-34-37)22(8-19(20)27)40-18-13-39-14-18/h8-9,12,16-18H,4-7,10,13-14H2,1-3H3,(H2,29,30,31,32)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161669
PNG
(US9682976, 128)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OC3CCNCC3)c(OC(F)F)c2)ncc1F |r|
Show InChI InChI=1S/C26H35F3N6O2/c1-26(2)14-17(12-18-4-3-11-35(18)26)32-23-20(27)15-31-25(34-23)33-16-5-6-21(22(13-16)37-24(28)29)36-19-7-9-30-10-8-19/h5-6,13,15,17-19,24,30H,3-4,7-12,14H2,1-2H3,(H2,31,32,33,34)/t17-,18+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161683
PNG
(US9682976, 141)
Show SMILES Cc1nnnn1-c1cc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)ccc1F |r|
Show InChI InChI=1S/C22H27F2N9/c1-13-29-30-31-33(13)19-10-14(6-7-17(19)23)27-21-25-12-18(24)20(28-21)26-15-9-16-5-4-8-32(16)22(2,3)11-15/h6-7,10,12,15-16H,4-5,8-9,11H2,1-3H3,(H2,25,26,27,28)/t15-,16+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161701
PNG
(US9682976, 152)
Show SMILES COc1cc(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc(c1)-n1nnnc1C |r|
Show InChI InChI=1S/C23H30ClN9O/c1-14-29-30-31-33(14)18-8-15(10-19(11-18)34-4)27-22-25-13-20(24)21(28-22)26-16-9-17-6-5-7-32(17)23(2,3)12-16/h8,10-11,13,16-17H,5-7,9,12H2,1-4H3,(H2,25,26,27,28)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161712
PNG
(US9682976, 160)
Show SMILES COCCOc1ccc(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)c(F)c1OCCOC |r|
Show InChI InChI=1S/C26H37F2N5O4/c1-26(2)15-17(14-18-6-5-9-33(18)26)30-24-19(27)16-29-25(32-24)31-20-7-8-21(36-12-10-34-3)23(22(20)28)37-13-11-35-4/h7-8,16-18H,5-6,9-15H2,1-4H3,(H2,29,30,31,32)/t17-,18+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161747
PNG
(BDBM161772 | US9682976, 189 | US9682976, 219)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCO)c(c2)C#N)ncc1F |r|
Show InChI InChI=1S/C23H29FN6O2/c1-23(2)12-17(11-18-4-3-7-30(18)23)27-21-19(24)14-26-22(29-21)28-16-5-6-20(32-9-8-31)15(10-16)13-25/h5-6,10,14,17-18,31H,3-4,7-9,11-12H2,1-2H3,(H2,26,27,28,29)/t17-,18+/m1/s1
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n/an/an/an/a<500n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161751
PNG
(US9682976, 192)
Show SMILES CN(C)CCOc1cc(F)c(Nc2ncc(F)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C26H36F2N10O2/c1-26(2)14-16(11-17-7-6-8-37(17)26)30-23-19(28)15-29-24(32-23)31-20-13-21(38-25(39)36(5)33-34-38)22(12-18(20)27)40-10-9-35(3)4/h12-13,15-17H,6-11,14H2,1-5H3,(H2,29,30,31,32)/t16-,17+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161774
PNG
(US9682976, 212)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC(O)CO)c(c2)C#N)ncc1F |r|
Show InChI InChI=1S/C24H31FN6O3/c1-24(2)10-17(9-18-4-3-7-31(18)24)28-22-20(25)12-27-23(30-22)29-16-5-6-21(15(8-16)11-26)34-14-19(33)13-32/h5-6,8,12,17-19,32-33H,3-4,7,9-10,13-14H2,1-2H3,(H2,27,28,29,30)/t17-,18+,19?/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161776
PNG
(US9682976, 214)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCC(O)CO)c(c2)-n2cnnn2)ncc1F |r|
Show InChI InChI=1S/C24H32FN9O3/c1-24(2)10-16(8-17-4-3-7-33(17)24)28-22-19(25)11-26-23(30-22)29-15-5-6-21(37-13-18(36)12-35)20(9-15)34-14-27-31-32-34/h5-6,9,11,14,16-18,35-36H,3-4,7-8,10,12-13H2,1-2H3,(H2,26,28,29,30)/t16-,17+,18?/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161400
PNG
(US9682976, 186 | US9682976, 221 | US9682976, 77)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCO)c1=O |r|
Show InChI InChI=1S/C24H31F2N9O3/c1-24(2)12-14(9-15-5-4-6-34(15)24)28-21-17(26)13-27-22(30-21)29-18-11-19(35-23(37)33(3)31-32-35)20(10-16(18)25)38-8-7-36/h10-11,13-15,36H,4-9,12H2,1-3H3,(H2,27,28,29,30)/t14-,15+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161777
PNG
(US9682976, 215 | US9682976, 218 | US9682976, 224)
Show SMILES CC1(C)C[C@@H](C[C@@H]2CCCN12)Nc1nc(Nc2ccc(OCCCO)c(c2)-n2cnnn2)ncc1F |r|
Show InChI InChI=1S/C24H32FN9O2/c1-24(2)13-17(11-18-5-3-8-33(18)24)28-22-19(25)14-26-23(30-22)29-16-6-7-21(36-10-4-9-35)20(12-16)34-15-27-31-32-34/h6-7,12,14-15,17-18,35H,3-5,8-11,13H2,1-2H3,(H2,26,28,29,30)/t17-,18+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161788
PNG
(US9682976, 226)
Show SMILES Cn1nnn(-c2cc(Nc3ncc(F)c(N[C@@H]4C[C@@H]5CCCN5C(C)(C)C4)n3)c(F)cc2OCCNC(=O)OC(C)(C)C)c1=O |r|
Show InChI InChI=1S/C29H40F2N10O4/c1-28(2,3)45-26(42)32-9-11-44-23-13-19(30)21(14-22(23)41-27(43)39(6)37-38-41)35-25-33-16-20(31)24(36-25)34-17-12-18-8-7-10-40(18)29(4,5)15-17/h13-14,16-18H,7-12,15H2,1-6H3,(H,32,42)(H2,33,34,35,36)/t17-,18+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161791
PNG
(US9682976, 229)
Show SMILES CC(O)COc1ccc(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1C#N |r|
Show InChI InChI=1S/C24H31ClN6O2/c1-15(32)14-33-21-7-6-17(9-16(21)12-26)29-23-27-13-20(25)22(30-23)28-18-10-19-5-4-8-31(19)24(2,3)11-18/h6-7,9,13,15,18-19,32H,4-5,8,10-11,14H2,1-3H3,(H2,27,28,29,30)/t15?,18-,19+/m1/s1
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Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161796
PNG
(US9682976, 234)
Show SMILES CO[C@@H](C)COc1cc(F)c(Nc2ncc(F)c(n2)N(C[C@H](C)OC)[C@@H]2C[C@@H]3CCCN3C(C)(C)C2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C30H43F2N9O4/c1-18(43-6)16-39(21-11-20-9-8-10-40(20)30(3,4)14-21)27-23(32)15-33-28(35-27)34-24-13-25(41-29(42)38(5)36-37-41)26(12-22(24)31)45-17-19(2)44-7/h12-13,15,18-21H,8-11,14,16-17H2,1-7H3,(H,33,34,35)/t18-,19-,20-,21+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM161800
PNG
(US9682976, 238)
Show SMILES CO[C@@H](C)COc1cc(F)c(Nc2ncc(Cl)c(N[C@@H]3C[C@@H]4CCCN4C(C)(C)C3)n2)cc1-n1nnn(C)c1=O |r|
Show InChI InChI=1S/C26H35ClFN9O3/c1-15(39-5)14-40-22-10-19(28)20(11-21(22)37-25(38)35(4)33-34-37)31-24-29-13-18(27)23(32-24)30-16-9-17-7-6-8-36(17)26(2,3)12-16/h10-11,13,15-17H,6-9,12,14H2,1-5H3,(H2,29,30,31,32)/t15-,16+,17-/m0/s1
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n/an/an/an/a<1.00E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc.

US Patent


Assay Description
Primary T cell stimulation and IL2 ELISA: Human primary T cells (100,000 cells per well) were pre-incubated with or without test compound in Yssel...

US Patent US9682976 (2017)


BindingDB Entry DOI: 10.7270/Q2DJ5CT2
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 324 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%