Affinity Data by Patent

Patent code US9688664

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM174013 (4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	9.0	n/a
Janssen Pharmaceutica NV US Patent					Assay Description T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1�15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...				US Patent US9688664 (2017) BindingDB Entry DOI: 10.7270/Q2FB513R
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM174013 (4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	320	n/a	n/a	n/a	n/a	9.0	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Transfected SK-N-MC cells (contents of 1�15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0.2% Glycerol,...				US Patent US9688664 (2017) BindingDB Entry DOI: 10.7270/Q2FB513R
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM188461 (US9169224, 150 \| US9688664, Comparator Compound) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	340	n/a	n/a	n/a	n/a	9.0	n/a
Janssen Pharmaceutica NV US Patent					Assay Description T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1�15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...				US Patent US9688664 (2017) BindingDB Entry DOI: 10.7270/Q2FB513R
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM188461 (US9169224, 150 \| US9688664, Comparator Compound) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	450	n/a	n/a	n/a	n/a	9.0	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Transfected SK-N-MC cells (contents of 1�15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0.2% Glycerol,...				US Patent US9688664 (2017) BindingDB Entry DOI: 10.7270/Q2FB513R
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM188461 (US9169224, 150 \| US9688664, Comparator Compound) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...				US Patent US9688664 (2017) BindingDB Entry DOI: 10.7270/Q2FB513R
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM188461 (US9169224, 150 \| US9688664, Comparator Compound) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...				US Patent US9688664 (2017) BindingDB Entry DOI: 10.7270/Q2FB513R
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM174013 (4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...				US Patent US9688664 (2017) BindingDB Entry DOI: 10.7270/Q2FB513R
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM174013 (4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...				US Patent US9688664 (2017) BindingDB Entry DOI: 10.7270/Q2FB513R
Janssen Pharmaceutica NV US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%