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Patent code US9695183

Compile Data Set for Download or QSAR

Found 702 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163879
PNG
(US9062078, 11 | US9062078, 12A | US9062078, 12B | ...)
Show SMILES Fc1ccc(OCC2CC3CCC2N3C(=O)c2ccccc2-c2cccs2)nc1 |THB:6:7:11.10:13|
Show InChI InChI=1S/C23H21FN2O2S/c24-16-7-10-22(25-13-16)28-14-15-12-17-8-9-20(15)26(17)23(27)19-5-2-1-4-18(19)21-6-3-11-29-21/h1-7,10-11,13,15,17,20H,8-9,12,14H2
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 3 -45.2n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163876
PNG
(US9062078, 10A | US9062078, 10B | US9062078, 9 | U...)
Show SMILES Cc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 |TLB:15:14:12.11:9|
Show InChI InChI=1S/C22H22FN5O2/c1-14-2-5-20(28-25-8-9-26-28)18(10-14)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3
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 3 -45.2n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM163876
PNG
(US9062078, 10A | US9062078, 10B | US9062078, 9 | U...)
Show SMILES Cc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 |TLB:15:14:12.11:9|
Show InChI InChI=1S/C22H22FN5O2/c1-14-2-5-20(28-25-8-9-26-28)18(10-14)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3
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 4 -44.6n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM164166
PNG
(US9062078, 296 | US9475819, 296 | US9637496, 296 |...)
Show SMILES Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncco1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C23H21F3N4O2/c1-13-3-2-4-16(20(13)21-27-9-10-32-21)22(31)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-28-19)23(24,25)26/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,28,29)
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 5 -44.0n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM163879
PNG
(US9062078, 11 | US9062078, 12A | US9062078, 12B | ...)
Show SMILES Fc1ccc(OCC2CC3CCC2N3C(=O)c2ccccc2-c2cccs2)nc1 |THB:6:7:11.10:13|
Show InChI InChI=1S/C23H21FN2O2S/c24-16-7-10-22(25-13-16)28-14-15-12-17-8-9-20(15)26(17)23(27)19-5-2-1-4-18(19)21-6-3-11-29-21/h1-7,10-11,13,15,17,20H,8-9,12,14H2
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 5 -49.8n/an/an/an/an/an/a40



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM164136
PNG
(US9062078, 266 | US9475819, 266 | US9637496, 409 |...)
Show SMILES Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C22H20F3N5O2/c1-12-3-2-4-14(19(12)20-26-7-8-32-20)21(31)30-13-5-6-16(30)15(9-13)29-18-11-27-17(10-28-18)22(23,24)25/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,28,29)
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 5 -44.0n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM164166
PNG
(US9062078, 296 | US9475819, 296 | US9637496, 296 |...)
Show SMILES Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncco1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C23H21F3N4O2/c1-13-3-2-4-16(20(13)21-27-9-10-32-21)22(31)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-28-19)23(24,25)26/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,28,29)
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 6 -43.6n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM164136
PNG
(US9062078, 266 | US9475819, 266 | US9637496, 409 |...)
Show SMILES Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C22H20F3N5O2/c1-12-3-2-4-14(19(12)20-26-7-8-32-20)21(31)30-13-5-6-16(30)15(9-13)29-18-11-27-17(10-28-18)22(23,24)25/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,28,29)
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 7 -43.3n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM164115
PNG
(US9062078, 245 | US9475819, 245 | US9637496, 245 |...)
Show SMILES Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C21H20F3N7O/c1-12-3-2-4-14(19(12)31-27-7-8-28-31)20(32)30-13-5-6-16(30)15(9-13)29-18-11-25-17(10-26-18)21(22,23)24/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,26,29)
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 7 -43.3n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163944
PNG
(US9062078, 75 | US9475819, 75 | US9637496, 75 | US...)
Show SMILES CCOc1ccc2cccnc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 |TLB:21:20:18.17:15|
Show InChI InChI=1S/C24H25N3O3/c1-2-29-20-11-8-16-6-5-13-26-23(16)22(20)24(28)27-18-9-10-19(27)17(14-18)15-30-21-7-3-4-12-25-21/h3-8,11-13,17-19H,2,9-10,14-15H2,1H3
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 7 -43.3n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163952
PNG
(US9062078, 164 | US9062078, 83 | US9475819, 83 | U...)
Show SMILES CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 |TLB:21:20:18.17:15|
Show InChI InChI=1S/C24H25N3O3/c1-2-29-23-22(19-8-4-3-7-16(19)14-26-23)24(28)27-18-10-11-20(27)17(13-18)15-30-21-9-5-6-12-25-21/h3-9,12,14,17-18,20H,2,10-11,13,15H2,1H3
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 7 -43.3n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM164165
PNG
(US9062078, 295 | US9475819, 295 | US9637496, 295 |...)
Show SMILES Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-n1nccn1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-9-10-28-31)21(32)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-26-19)22(23,24)25/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,26,29)
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 8 -43.0n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM164062
PNG
(US9062078, 192 | US9062078, 279 | US9475819, 192 |...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-c1ncccn1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C23H19F4N5O/c24-16-4-1-3-15(20(16)21-28-9-2-10-29-21)22(33)32-14-6-7-18(32)17(11-14)31-19-8-5-13(12-30-19)23(25,26)27/h1-5,8-10,12,14,17-18H,6-7,11H2,(H,30,31)
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 8 -43.0n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM163952
PNG
(US9062078, 164 | US9062078, 83 | US9475819, 83 | U...)
Show SMILES CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 |TLB:21:20:18.17:15|
Show InChI InChI=1S/C24H25N3O3/c1-2-29-23-22(19-8-4-3-7-16(19)14-26-23)24(28)27-18-10-11-20(27)17(13-18)15-30-21-9-5-6-12-25-21/h3-9,12,14,17-18,20H,2,10-11,13,15H2,1H3
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 9 -42.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM164153
PNG
(US9062078, 283 | US9475819, 283 | US9637496, 283 |...)
Show SMILES Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncco1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C22H20F3N5O2/c1-12-3-2-4-15(18(12)19-26-7-8-32-19)20(31)30-14-5-6-17(30)16(9-14)29-21-27-10-13(11-28-21)22(23,24)25/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,27,28,29)
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 9 -42.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM164165
PNG
(US9062078, 295 | US9475819, 295 | US9637496, 295 |...)
Show SMILES Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-n1nccn1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C22H21F3N6O/c1-13-3-2-4-16(20(13)31-27-9-10-28-31)21(32)30-15-6-7-18(30)17(11-15)29-19-8-5-14(12-26-19)22(23,24)25/h2-5,8-10,12,15,17-18H,6-7,11H2,1H3,(H,26,29)
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 9 -42.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM163873
PNG
(US9062078, 111 | US9062078, 7 | US9062078, 8A | US...)
Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 |TLB:15:14:12.11:9|
Show InChI InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3
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 9 -42.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163888
PNG
(US9062078, 167 | US9062078, 19 | US9475819, 19 | U...)
Show SMILES Cc1ccc(OCC2CC3CCC2N3C(=O)c2cc(C)ccc2-n2nccn2)nc1 |THB:6:7:11.10:13|
Show InChI InChI=1S/C23H25N5O2/c1-15-3-6-21(28-25-9-10-26-28)19(11-15)23(29)27-18-5-7-20(27)17(12-18)14-30-22-8-4-16(2)13-24-22/h3-4,6,8-11,13,17-18,20H,5,7,12,14H2,1-2H3
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 9 -42.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163902
PNG
(US9062078, 33 | US9475819, 33 | US9637496, 33 | US...)
Show SMILES Cc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 |TLB:21:20:18.17:15|
Show InChI InChI=1S/C24H23FN4O2/c1-15-3-6-19(23-26-9-2-10-27-23)20(11-15)24(30)29-18-5-7-21(29)16(12-18)14-31-22-8-4-17(25)13-28-22/h2-4,6,8-11,13,16,18,21H,5,7,12,14H2,1H3
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 9 -42.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163876
PNG
(US9062078, 10A | US9062078, 10B | US9062078, 9 | U...)
Show SMILES Cc1ccc(c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 |TLB:15:14:12.11:9|
Show InChI InChI=1S/C22H22FN5O2/c1-14-2-5-20(28-25-8-9-26-28)18(10-14)22(29)27-17-4-6-19(27)15(11-17)13-30-21-7-3-16(23)12-24-21/h2-3,5,7-10,12,15,17,19H,4,6,11,13H2,1H3
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 9 -42.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM164130
PNG
(US9062078, 260 | US9475819, 260 | US9637496, 260 |...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C21H17F4N5O2/c22-13-3-1-2-12(18(13)19-26-6-7-32-19)20(31)30-11-4-5-15(30)14(8-11)29-17-10-27-16(9-28-17)21(23,24)25/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,28,29)
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 10 -42.4n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163958
PNG
(US9062078, 89 | US9475819, 89 | US9637496, 89 | US...)
Show SMILES CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 |TLB:21:20:18.17:15|
Show InChI InChI=1S/C25H26N2O3/c1-2-29-22-13-10-17-7-3-4-8-20(17)24(22)25(28)27-19-11-12-21(27)18(15-19)16-30-23-9-5-6-14-26-23/h3-10,13-14,18-19,21H,2,11-12,15-16H2,1H3
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 10 -42.4n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM163915
PNG
(US9062078, 46 | US9475819, 46 | US9637496, 46 | US...)
Show SMILES Cc1cc(C)nc(OCC2CC3CCC2N3C(=O)c2ccccc2-c2cccs2)n1 |THB:8:9:13.12:15|
Show InChI InChI=1S/C24H25N3O2S/c1-15-12-16(2)26-24(25-15)29-14-17-13-18-9-10-21(17)27(18)23(28)20-7-4-3-6-19(20)22-8-5-11-30-22/h3-8,11-12,17-18,21H,9-10,13-14H2,1-2H3
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 10 -48.0n/an/an/an/an/an/a40



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM164115
PNG
(US9062078, 245 | US9475819, 245 | US9637496, 245 |...)
Show SMILES Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-n1nccn1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C21H20F3N7O/c1-12-3-2-4-14(19(12)31-27-7-8-28-31)20(32)30-13-5-6-16(30)15(9-13)29-18-11-25-17(10-26-18)21(22,23)24/h2-4,7-8,10-11,13,15-16H,5-6,9H2,1H3,(H,26,29)
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 10 -42.4n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163879
PNG
(US9062078, 11 | US9062078, 12A | US9062078, 12B | ...)
Show SMILES Fc1ccc(OCC2CC3CCC2N3C(=O)c2ccccc2-c2cccs2)nc1 |THB:6:7:11.10:13|
Show InChI InChI=1S/C23H21FN2O2S/c24-16-7-10-22(25-13-16)28-14-15-12-17-8-9-20(15)26(17)23(27)19-5-2-1-4-18(19)21-6-3-11-29-21/h1-7,10-11,13,15,17,20H,8-9,12,14H2
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 10 -42.4n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM163977
PNG
(US9062078, 108 | US9475819, 108 | US9637496, 108 |...)
Show SMILES COc1cccc(c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 |TLB:16:15:13.12:10|
Show InChI InChI=1S/C22H22FN5O3/c1-30-19-4-2-3-18(28-25-9-10-26-28)21(19)22(29)27-16-6-7-17(27)14(11-16)13-31-20-8-5-15(23)12-24-20/h2-5,8-10,12,14,16-17H,6-7,11,13H2,1H3
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 10 -42.4n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163961
PNG
(US9062078, 92 | US9475819, 92 | US9637496, 92 | US...)
Show SMILES Cc1nc(C(=O)N2C3CCC2C(COc2ccccn2)C3)c(s1)-c1ccccc1 |TLB:12:11:9.8:6|
Show InChI InChI=1S/C23H23N3O2S/c1-15-25-21(22(29-15)16-7-3-2-4-8-16)23(27)26-18-10-11-19(26)17(13-18)14-28-20-9-5-6-12-24-20/h2-9,12,17-19H,10-11,13-14H2,1H3
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 11 -42.2n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM163897
PNG
(US9062078, 28 | US9475819, 28 | US9637496, 28 | US...)
Show SMILES CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 |TLB:21:20:18.17:15|
Show InChI InChI=1S/C25H25FN2O3/c1-2-30-22-11-7-16-5-3-4-6-20(16)24(22)25(29)28-19-9-10-21(28)17(13-19)15-31-23-12-8-18(26)14-27-23/h3-8,11-12,14,17,19,21H,2,9-10,13,15H2,1H3
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 11 -47.7n/an/an/an/an/an/a40



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM163958
PNG
(US9062078, 89 | US9475819, 89 | US9637496, 89 | US...)
Show SMILES CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 |TLB:21:20:18.17:15|
Show InChI InChI=1S/C25H26N2O3/c1-2-29-22-13-10-17-7-3-4-8-20(17)24(22)25(28)27-19-11-12-21(27)18(15-19)16-30-23-9-5-6-14-26-23/h3-10,13-14,18-19,21H,2,11-12,15-16H2,1H3
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 11 -42.2n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163898
PNG
(US9062078, 29 | US9475819, 29 | US9637496, 29 | US...)
Show SMILES Cc1nc(C(=O)N2C3CCC2C(COc2ccc(F)cn2)C3)c(s1)-c1ccccc1F |TLB:12:11:9.8:6|
Show InChI InChI=1S/C23H21F2N3O2S/c1-13-27-21(22(31-13)17-4-2-3-5-18(17)25)23(29)28-16-7-8-19(28)14(10-16)12-30-20-9-6-15(24)11-26-20/h2-6,9,11,14,16,19H,7-8,10,12H2,1H3
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 11 -42.2n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM164143
PNG
(US9062078, 273 | US9475819, 273 | US9637496, 273 |...)
Show SMILES Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncccn1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C23H21F3N6O/c1-13-4-2-5-15(20(13)21-27-8-3-9-28-21)22(33)32-14-6-7-17(32)16(10-14)31-19-12-29-18(11-30-19)23(24,25)26/h2-5,8-9,11-12,14,16-17H,6-7,10H2,1H3,(H,30,31)
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 12 -42.0n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM163879
PNG
(US9062078, 11 | US9062078, 12A | US9062078, 12B | ...)
Show SMILES Fc1ccc(OCC2CC3CCC2N3C(=O)c2ccccc2-c2cccs2)nc1 |THB:6:7:11.10:13|
Show InChI InChI=1S/C23H21FN2O2S/c24-16-7-10-22(25-13-16)28-14-15-12-17-8-9-20(15)26(17)23(27)19-5-2-1-4-18(19)21-6-3-11-29-21/h1-7,10-11,13,15,17,20H,8-9,12,14H2
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 12 -47.5n/an/an/an/an/an/a40



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163887
PNG
(US9062078, 18 | US9475819, 18 | US9637496, 18 | US...)
Show SMILES Cc1ccc(c(c1)C(=O)N1C2CCC1C(COc1cccc(C)n1)C2)-n1nccn1 |TLB:15:14:12.11:9|
Show InChI InChI=1S/C23H25N5O2/c1-15-6-8-21(28-24-10-11-25-28)19(12-15)23(29)27-18-7-9-20(27)17(13-18)14-30-22-5-3-4-16(2)26-22/h3-6,8,10-12,17-18,20H,7,9,13-14H2,1-2H3
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 12 -42.0n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM163977
PNG
(US9062078, 108 | US9475819, 108 | US9637496, 108 |...)
Show SMILES COc1cccc(c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 |TLB:16:15:13.12:10|
Show InChI InChI=1S/C22H22FN5O3/c1-30-19-4-2-3-18(28-25-9-10-26-28)21(19)22(29)27-16-6-7-17(27)14(11-16)13-31-20-8-5-15(23)12-24-20/h2-5,8-10,12,14,16-17H,6-7,11,13H2,1H3
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 12 -47.5n/an/an/an/an/an/a40



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163888
PNG
(US9062078, 167 | US9062078, 19 | US9475819, 19 | U...)
Show SMILES Cc1ccc(OCC2CC3CCC2N3C(=O)c2cc(C)ccc2-n2nccn2)nc1 |THB:6:7:11.10:13|
Show InChI InChI=1S/C23H25N5O2/c1-15-3-6-21(28-25-9-10-26-28)19(11-15)23(29)27-18-5-7-20(27)17(12-18)14-30-22-8-4-16(2)13-24-22/h3-4,6,8-11,13,17-18,20H,5,7,12,14H2,1-2H3
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 12 -42.0n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163977
PNG
(US9062078, 108 | US9475819, 108 | US9637496, 108 |...)
Show SMILES COc1cccc(c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 |TLB:16:15:13.12:10|
Show InChI InChI=1S/C22H22FN5O3/c1-30-19-4-2-3-18(28-25-9-10-26-28)21(19)22(29)27-16-6-7-17(27)14(11-16)13-31-20-8-5-15(23)12-24-20/h2-5,8-10,12,14,16-17H,6-7,11,13H2,1H3
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 12 -42.0n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163952
PNG
(US9062078, 164 | US9062078, 83 | US9475819, 83 | U...)
Show SMILES CCOc1ncc2ccccc2c1C(=O)N1C2CCC1C(COc1ccccn1)C2 |TLB:21:20:18.17:15|
Show InChI InChI=1S/C24H25N3O3/c1-2-29-23-22(19-8-4-3-7-16(19)14-26-23)24(28)27-18-10-11-20(27)17(13-18)15-30-21-9-5-6-12-25-21/h3-9,12,14,17-18,20H,2,10-11,13,15H2,1H3
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 12 -42.0n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM164159
PNG
(US9062078, 289 | US9475819, 289 | US9637496, 289 |...)
Show SMILES COc1cccc(-c2ncccn2)c1C(=O)N1C2CCC1C(C2)Nc1cnc(cn1)C(F)(F)F |TLB:23:21:19.18:16|
Show InChI InChI=1S/C23H21F3N6O2/c1-34-17-5-2-4-14(21-27-8-3-9-28-21)20(17)22(33)32-13-6-7-16(32)15(10-13)31-19-12-29-18(11-30-19)23(24,25)26/h2-5,8-9,11-13,15-16H,6-7,10H2,1H3,(H,30,31)
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 13 -41.8n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163989
PNG
(US9062078, 120 | US9475819, 120 | US9637496, 120 |...)
Show SMILES Fc1ccc(OCC2CC3CCC2N3C(=O)c2cc(Cl)ccc2-n2nccn2)nc1 |THB:6:7:11.10:13|
Show InChI InChI=1S/C21H19ClFN5O2/c22-14-1-4-19(28-25-7-8-26-28)17(10-14)21(29)27-16-3-5-18(27)13(9-16)12-30-20-6-2-15(23)11-24-20/h1-2,4,6-8,10-11,13,16,18H,3,5,9,12H2
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 14 -41.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163873
PNG
(US9062078, 111 | US9062078, 7 | US9062078, 8A | US...)
Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2)-n1nccn1 |TLB:15:14:12.11:9|
Show InChI InChI=1S/C21H21FN6O2/c1-13-2-5-18(28-24-8-9-25-28)20(26-13)21(29)27-16-4-6-17(27)14(10-16)12-30-19-7-3-15(22)11-23-19/h2-3,5,7-9,11,14,16-17H,4,6,10,12H2,1H3
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 14 -41.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163897
PNG
(US9062078, 28 | US9475819, 28 | US9637496, 28 | US...)
Show SMILES CCOc1ccc2ccccc2c1C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 |TLB:21:20:18.17:15|
Show InChI InChI=1S/C25H25FN2O3/c1-2-30-22-11-7-16-5-3-4-6-20(16)24(22)25(29)28-19-9-10-21(28)17(13-19)15-31-23-12-8-18(26)14-27-23/h3-8,11-12,14,17,19,21H,2,9-10,13,15H2,1H3
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 14 -41.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM164153
PNG
(US9062078, 283 | US9475819, 283 | US9637496, 283 |...)
Show SMILES Cc1cccc(C(=O)N2C3CCC2C(C3)Nc2ncc(cn2)C(F)(F)F)c1-c1ncco1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C22H20F3N5O2/c1-12-3-2-4-15(18(12)19-26-7-8-32-19)20(31)30-14-5-6-17(30)16(9-14)29-21-27-10-13(11-28-21)22(23,24)25/h2-4,7-8,10-11,14,16-17H,5-6,9H2,1H3,(H,27,28,29)
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 14 -41.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM163869
PNG
(US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...)
Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9|
Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3
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 14 -41.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM163869
PNG
(US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...)
Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9|
Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3
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 14 -41.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM164130
PNG
(US9062078, 260 | US9475819, 260 | US9637496, 260 |...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2cnc(cn2)C(F)(F)F)c1-c1ncco1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C21H17F4N5O2/c22-13-3-1-2-12(18(13)19-26-6-7-32-19)20(31)30-11-4-5-15(30)14(8-11)29-17-10-27-16(9-28-17)21(23,24)25/h1-3,6-7,9-11,14-15H,4-5,8H2,(H,28,29)
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 14 -41.7n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))		BDBM163888
PNG
(US9062078, 167 | US9062078, 19 | US9475819, 19 | U...)
Show SMILES Cc1ccc(OCC2CC3CCC2N3C(=O)c2cc(C)ccc2-n2nccn2)nc1 |THB:6:7:11.10:13|
Show InChI InChI=1S/C23H25N5O2/c1-15-3-6-21(28-25-9-10-26-28)19(11-15)23(29)27-18-5-7-20(27)17(12-18)14-30-22-8-4-16(2)13-24-22/h3-4,6,8-11,13,17-18,20H,5,7,12,14H2,1-2H3
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 14 -47.1n/an/an/an/an/an/a40



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Rattus norvegicus (Rat))		BDBM163902
PNG
(US9062078, 33 | US9475819, 33 | US9637496, 33 | US...)
Show SMILES Cc1ccc(-c2ncccn2)c(c1)C(=O)N1C2CCC1C(COc1ccc(F)cn1)C2 |TLB:21:20:18.17:15|
Show InChI InChI=1S/C24H23FN4O2/c1-15-3-6-19(23-26-9-2-10-27-23)20(11-15)24(30)29-18-5-7-21(29)16(12-18)14-31-22-8-4-17(25)13-28-22/h2-4,6,8-11,13,16,18,21H,5,7,12,14H2,1H3
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 15 -41.5n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163869
PNG
(US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...)
Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9|
Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3
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 15 -41.5n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM164164
PNG
(US9062078, 294 | US9475819, 294 | US9637496, 294 |...)
Show SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Nc2ccc(cn2)C(F)(F)F)c1-n1nccn1 |TLB:15:13:11.10:8|
Show InChI InChI=1S/C21H18F4N6O/c22-15-3-1-2-14(19(15)31-27-8-9-28-31)20(32)30-13-5-6-17(30)16(10-13)29-18-7-4-12(11-26-18)21(23,24)25/h1-4,7-9,11,13,16-17H,5-6,10H2,(H,26,29)
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 15 -41.5n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Orexin/Hypocretin receptor type 1


(Homo sapiens (Human))		BDBM163869
PNG
(US9062078, 4 | US9062078, 5A | US9062078, 5B | US9...)
Show SMILES Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9|
Show InChI InChI=1S/C21H22N6O2/c1-14-5-7-18(27-23-10-11-24-27)20(25-14)21(28)26-16-6-8-17(26)15(12-16)13-29-19-4-2-3-9-22-19/h2-5,7,9-11,15-17H,6,8,12-13H2,1H3
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 15 -41.5n/an/an/an/an/an/a4



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...

US Patent US9695183 (2017)


BindingDB Entry DOI: 10.7270/Q2N58JHM
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 702 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%