Found 5 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 2
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM5566
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| MMDB PDB Article PubMed
| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Universitario de Bio-Org£nica Antonio Gonz£lez (IUBO-AG)
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
Bioorg Med Chem Lett 21: 6641-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.069 BindingDB Entry DOI: 10.7270/Q22B8ZDP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM5566
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| 1.30E+3 | -34.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
J Med Chem 43: 2797-804 (2000)
Article DOI: 10.1021/jm990628o BindingDB Entry DOI: 10.7270/Q20R9MKP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM5566
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
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DrugBank MCE MMDB PC cid PC sid PDB UniChem
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| PDB Article
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of CDK2/cyclinA (unknown origin) |
Citation and Details
Article DOI: 10.1007/s00044-013-0571-y BindingDB Entry DOI: 10.7270/Q2Q2434C |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM5566
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
J Med Chem 43: 2797-804 (2000)
Article DOI: 10.1021/jm990628o BindingDB Entry DOI: 10.7270/Q20R9MKP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM5566
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
Bioorg Med Chem Lett 13: 3079-82 (2003)
Article DOI: 10.1016/s0960-894x(03)00651-6 BindingDB Entry DOI: 10.7270/Q2R78CDT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |