Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Carbonic anhydrase 2 (260/260 = 100%)† (Homo sapiens (Human)) | BDBM13057 (CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL | Assay Description Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assay | J Med Chem 48: 1941-7 (2005) Article DOI: 10.1021/jm040124c BindingDB Entry DOI: 10.7270/Q2SQ9152 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Carbonic anhydrase 2 (260/260 = 100%)† (Homo sapiens (Human)) | BDBM13057 (CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL | Assay Description Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assay | J Med Chem 48: 1941-7 (2005) Article DOI: 10.1021/jm040124c BindingDB Entry DOI: 10.7270/Q2SQ9152 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Carbonic anhydrase 2 (260/260 = 100%)† (Homo sapiens (Human)) | BDBM13057 (CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 36 | -42.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universite Montpellier II | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | J Med Chem 49: 7024-31 (2006) Article DOI: 10.1021/jm060807n BindingDB Entry DOI: 10.7270/Q24T6GKT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Carbonic anhydrase 2 (260/260 = 100%)† (Homo sapiens (Human)) | BDBM13057 (CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL | Assay Description Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assay | J Med Chem 48: 1941-7 (2005) Article DOI: 10.1021/jm040124c BindingDB Entry DOI: 10.7270/Q2SQ9152 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Carbonic anhydrase 2 (260/260 = 100%)† (Homo sapiens (Human)) | BDBM13057 (CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL | Assay Description Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assay | J Med Chem 48: 1941-7 (2005) Article DOI: 10.1021/jm040124c BindingDB Entry DOI: 10.7270/Q2SQ9152 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Carbonic anhydrase 2 (260/260 = 100%)† (Homo sapiens (Human)) | BDBM13057 (CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bath Curated by ChEMBL | Assay Description Compound was tested for inhibition of human carbonic anhydrase (hCA II) | Bioorg Med Chem Lett 13: 863-5 (2003) BindingDB Entry DOI: 10.7270/Q2319WFW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Carbonic anhydrase 2 (260/260 = 100%)† (Homo sapiens (Human)) | BDBM13057 (CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL | Assay Description Binding affinity to human CA2 by ThermoFluor assay | J Med Chem 49: 3496-500 (2006) Article DOI: 10.1021/jm058279n BindingDB Entry DOI: 10.7270/Q2XP75RG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |