Affinity Data by PDB ID

PDB code 1HWW

Found 1 hit Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-mannosidase 2 (1014/1015 > 99%)^† (Drosophila melanogaster (Fruit fly))	BDBM50168995 ((-)-swainsonine \| (1S,2R,8R,8aR)-Octahydro-indoliz...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	3	-48.6	37	n/a	n/a	n/a	n/a	5.75	25
University of Toronto					Assay Description Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...				Chembiochem 11: 673-80 (2010) Article DOI: 10.1002/cbic.200900750 BindingDB Entry DOI: 10.7270/Q2WS8RRM
University of Toronto					More data for this Ligand-Target Pair				3D Structure (crystal)

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output