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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 (270/315 = 86%)† (Rattus norvegicus) | BDBM16496 (2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet  | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB PubMed | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
National Eye Institute Curated by ChEMBL | Assay Description Inhibitory activity against purified rat lens aldose reductase (RLAR) | J Med Chem 37: 787-92 (1994) BindingDB Entry DOI: 10.7270/Q2G73FCT | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Aldo-keto reductase family 1 member B1 (316/316 = 100%)† (Homo sapiens (Human)) | BDBM16496 (2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute for Diabetes Discovery | Assay Description The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear... | J Med Chem 48: 3141-52 (2005) Article DOI: 10.1021/jm0492094 BindingDB Entry DOI: 10.7270/Q2J38QSN | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Aldo-keto reductase family 1 member B1 (274/316 = 87%)† (Sus scrofa) | BDBM16496 (2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB Article | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrate | Bioorg Med Chem Lett 7: 1677-1682 (1997) Article DOI: 10.1016/S0960-894X(97)00287-4 BindingDB Entry DOI: 10.7270/Q2M61K7T | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Aldo-keto reductase family 1 member B1 (316/316 = 100%)† (Homo sapiens (Human)) | BDBM16496 (2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | PDB PubMed | n/a | n/a | 42.4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Eye Institute Curated by ChEMBL | Assay Description Inhibitory Activity against Human recombinant Aldose Reductase (wild type) | J Med Chem 43: 1062-70 (2000) BindingDB Entry DOI: 10.7270/Q2QZ2BPN | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Aldo-keto reductase family 1 member B1 (316/316 = 100%)† (Homo sapiens (Human)) | BDBM16496 (2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of aldose reductase | Bioorg Med Chem 15: 7865-77 (2007) Article DOI: 10.1016/j.bmc.2007.08.019 BindingDB Entry DOI: 10.7270/Q2QR4WV6 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
