Affinity Data by PDB ID

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PDB code 1IPC

Identical Ligands in BindingDB

Found 4 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Eukaryotic translation initiation factor 4E (217/217 = 100%)^† (Homo sapiens (Human))	BDBM50316302 (((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay				J Med Chem 55: 3837-51 (2012) Article DOI: 10.1021/jm300037x BindingDB Entry DOI: 10.7270/Q27082GX
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Eukaryotic translation initiation factor 4E (214/217 = 99%)^† (Oryctolagus cuniculus)	BDBM50316302 (((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...				Bioorg Med Chem 23: 5369-81 (2015) Article DOI: 10.1016/j.bmc.2015.07.052 BindingDB Entry DOI: 10.7270/Q2DN46V3
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Eukaryotic translation initiation factor 4E (214/217 = 99%)^† (Oryctolagus cuniculus)	BDBM50316302 (((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	5.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...				Bioorg Med Chem 23: 5369-81 (2015) Article DOI: 10.1016/j.bmc.2015.07.052 BindingDB Entry DOI: 10.7270/Q2DN46V3
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Eukaryotic translation initiation factor 4E (213/217 = 98%)^† (Mus musculus)	BDBM50316302 (((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFA				Eur J Med Chem 45: 1304-13 (2010) Article DOI: 10.1016/j.ejmech.2009.11.054 BindingDB Entry DOI: 10.7270/Q21C1X1Q
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output