Found 5 hits Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Nitric oxide synthase, endothelial
(414/415 > 99%)†
(Homo sapiens (Human)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
| PDB
PubMed
| n/a | n/a | 1.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Groton
Curated by ChEMBL
| Assay Description
Inhibitory activity against human endothelial nitric oxide synthase (eNOS) |
Bioorg Med Chem Lett 9: 2569-72 (1999)
BindingDB Entry DOI: 10.7270/Q2BC3XRP |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Nitric oxide synthase, endothelial
(414/415 > 99%)†
(Homo sapiens (Human)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
| PDB
Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human endothelial nitric oxide synthase |
J Med Chem 47: 1575-86 (2004)
Article DOI: 10.1021/jm030519g
BindingDB Entry DOI: 10.7270/Q2J102MT |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Nitric oxide synthase, endothelial
(394/415 = 95%)†
(Bos taurus (bovine)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
| PDB
Article
PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Versailles
Curated by ChEMBL
| Assay Description
Inhibition of bovine recombinant eNOS |
Bioorg Med Chem 16: 5962-73 (2008)
Article DOI: 10.1016/j.bmc.2008.04.056
BindingDB Entry DOI: 10.7270/Q2GB23VM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Nitric oxide synthase, endothelial
(414/415 > 99%)†
(Homo sapiens (Human)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
| PDB
Article
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Tested to inhibit the conversion of [3H]-L-arginine to [3H]-L-citrulline catalyzed by endothelial NOS from human umbilical vein endothelial cells. |
Bioorg Med Chem Lett 5: 1573-1576 (1995)
Article DOI: 10.1016/0960-894X(95)00273-V
BindingDB Entry DOI: 10.7270/Q25T3KD0 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Nitric oxide synthase, endothelial
(394/415 = 95%)†
(Bos taurus (bovine)) | BDBM50209245
(CHEMBL247378)Show InChI InChI=1S/C7H5N3O2/c11-10(12)6-3-1-2-5-4-8-9-7(5)6/h1-4H,(H,8,9) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
| PDB
Article
PubMed
| n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Christian-Albrechts-University of Kiel
Curated by ChEMBL
| Assay Description
Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as conversion of [gamma-14C]L-arginine to [14C]L-citrulline by radioacti... |
Eur J Med Chem 44: 2877-87 (2009)
Article DOI: 10.1016/j.ejmech.2008.12.007
BindingDB Entry DOI: 10.7270/Q2KD1ZV6 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Search and Browse
