Found 8 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dipeptidyl peptidase 4
(728/728 = 100%)† (Homo sapiens (Human)) | BDBM50178428
((S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)butan-1-on...)Show InChI InChI=1S/C9H18N2O/c1-7(2)8(10)9(12)11-5-3-4-6-11/h7-8H,3-6,10H2,1-2H3/t8-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| MMDB PDB Article
| 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of platelet glycoprotein alpha IIb beta3 integrin in ELISA |
Bioorg Med Chem Lett 6: 1163-1166 (1996)
Article DOI: 10.1016/0960-894X(96)00190-4 BindingDB Entry DOI: 10.7270/Q279455Q |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(728/728 = 100%)† (Homo sapiens (Human)) | BDBM50178428
((S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)butan-1-on...)Show InChI InChI=1S/C9H18N2O/c1-7(2)8(10)9(12)11-5-3-4-6-11/h7-8H,3-6,10H2,1-2H3/t8-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| MMDB PDB Article PubMed
| 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astex Therapeutics Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to DPP4 |
J Med Chem 51: 3661-80 (2008)
Article DOI: 10.1021/jm8000373 BindingDB Entry DOI: 10.7270/Q2N58M4H |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(728/728 = 100%)† (Homo sapiens (Human)) | BDBM50118952
(2-Amino-3-methyl-1-pyrrolidin-1-yl-butan-1-one | C...)Show InChI InChI=1S/C9H18N2O/c1-7(2)8(10)9(12)11-5-3-4-6-11/h7-8H,3-6,10H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PDB US Patent
| n/a | n/a | 548 | n/a | n/a | n/a | n/a | 4.0 | n/a |
TBA
US Patent
| Assay Description The proteolytic enzyme, Dipeptidyle Peptidase IV (DppIV) was monitored in vitro by the substrate Gly-Pro 4-methoxy-β-naphthylamide while in the ... |
US Patent US9115082 (2015)
BindingDB Entry DOI: 10.7270/Q2JS9P7B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(728/728 = 100%)† (Homo sapiens (Human)) | BDBM50178428
((S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)butan-1-on...)Show InChI InChI=1S/C9H18N2O/c1-7(2)8(10)9(12)11-5-3-4-6-11/h7-8H,3-6,10H2,1-2H3/t8-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| MMDB PDB Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Santhera Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of DPP4 |
Bioorg Med Chem Lett 16: 1405-9 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.038 BindingDB Entry DOI: 10.7270/Q25M659R |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(728/728 = 100%)† (Homo sapiens (Human)) | BDBM50118952
(2-Amino-3-methyl-1-pyrrolidin-1-yl-butan-1-one | C...)Show InChI InChI=1S/C9H18N2O/c1-7(2)8(10)9(12)11-5-3-4-6-11/h7-8H,3-6,10H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
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| PDB Article PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) |
J Med Chem 46: 5005-14 (2003)
Article DOI: 10.1021/jm0308803 BindingDB Entry DOI: 10.7270/Q2W37X2F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(728/728 = 100%)† (Homo sapiens (Human)) | BDBM50178428
((S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)butan-1-on...)Show InChI InChI=1S/C9H18N2O/c1-7(2)8(10)9(12)11-5-3-4-6-11/h7-8H,3-6,10H2,1-2H3/t8-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
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| MMDB PDB PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description In vitro inhibition of human Dipeptidylpeptidase IV. |
Bioorg Med Chem Lett 12: 2825-8 (2002)
BindingDB Entry DOI: 10.7270/Q279457M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(728/728 = 100%)† (Homo sapiens (Human)) | BDBM50178428
((S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)butan-1-on...)Show InChI InChI=1S/C9H18N2O/c1-7(2)8(10)9(12)11-5-3-4-6-11/h7-8H,3-6,10H2,1-2H3/t8-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Warwick
Curated by ChEMBL
| Assay Description Inhibition of human DPP4 |
Eur J Med Chem 139: 482-491 (2017)
Article DOI: 10.1016/j.ejmech.2017.08.024 BindingDB Entry DOI: 10.7270/Q25B050P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dipeptidyl peptidase 4
(728/728 = 100%)† (Homo sapiens (Human)) | BDBM50178428
((S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)butan-1-on...)Show InChI InChI=1S/C9H18N2O/c1-7(2)8(10)9(12)11-5-3-4-6-11/h7-8H,3-6,10H2,1-2H3/t8-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp
Curated by ChEMBL
| Assay Description Inhibition of DPP4 (unknown origin) |
Bioorg Med Chem Lett 18: 4154-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.080 BindingDB Entry DOI: 10.7270/Q2G160N3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |