Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cGMP-specific 3',5'-cyclic phosphodiesterase [535-860] (325/326 > 99%)† (Homo sapiens (Human)) | BDBM15336 (1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | 7.8 | 24 |
University of North Carolina at Chapel Hill | Assay Description Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea... | J Biol Chem 281: 21469-79 (2006) Article DOI: 10.1074/jbc.M512527200 BindingDB Entry DOI: 10.7270/Q290221F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase [1-662,679-875] (309/326 = 95%)† (Homo sapiens (Human)) | BDBM15336 (1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | 7.8 | 24 |
University of North Carolina at Chapel Hill | Assay Description Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea... | J Biol Chem 281: 21469-79 (2006) Article DOI: 10.1074/jbc.M512527200 BindingDB Entry DOI: 10.7270/Q290221F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (325/326 > 99%)† (Homo sapiens (Human)) | BDBM15336 (1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 6.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Pharmaceutical Chemistry Curated by ChEMBL | Assay Description Inhibition of PDE5 from platelets | J Med Chem 44: 3746-9 (2001) BindingDB Entry DOI: 10.7270/Q2H13196 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase [1-660,682-875] (304/326 = 93%)† (Homo sapiens (Human)) | BDBM15336 (1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 9.50E+4 | n/a | n/a | n/a | n/a | 7.8 | 24 |
University of North Carolina at Chapel Hill | Assay Description Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea... | J Biol Chem 281: 21469-79 (2006) Article DOI: 10.1074/jbc.M512527200 BindingDB Entry DOI: 10.7270/Q290221F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |