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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Streptavidin (126/127 > 99%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet  | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 0 | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Research and Development, LLC Curated by ChEMBL | Assay Description Binding affinity to Streptomyces avidinii streptavidin by NMR analysis | J Med Chem 57: 7819-37 (2014) Article DOI: 10.1021/jm500325k BindingDB Entry DOI: 10.7270/Q2JW8GH3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kJ/mole | -TΔS° kJ/mole | ΔH° kJ/mole | log K | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|
| Streptavidin (126/127 > 99%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -123 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(W120F) (127/127 = 100%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -81.1 | n/a | n/a | 25 | |
University of Washington | J Am Chem Soc 117: 10622-10628 (1995) | |||||||||
| Streptavadin(Y43A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -90.4 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(S27A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -103 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(N23E) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -108 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(N23A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -90.0 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavidin (126/127 > 99%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -104 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavidin (Y43F) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -115 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(Y43A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -66.9 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(S27A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -97.5 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(N23E) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -100 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(N23A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -75.3 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavidin (126/127 > 99%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -102 | n/a | n/a | 25 | |
University of Washington | J Am Chem Soc 117: 10622-10628 (1995) | |||||||||
| Streptavadin(W79F) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -109 | n/a | n/a | 25.3 | |
University of Washington | J Am Chem Soc 117: 10622-10628 (1995) | |||||||||
| Streptavadin(W108F) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -98.2 | n/a | n/a | 25.2 | |
University of Washington | J Am Chem Soc 117: 10622-10628 (1995) | |||||||||
| Streptavidin (Y43F) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -118 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kJ/mole | -TΔS° kJ/mole | ΔH° kJ/mole | log K | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|
| Streptavidin (126/127 > 99%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -123 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(W120F) (127/127 = 100%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -81.1 | n/a | n/a | 25 | |
University of Washington | J Am Chem Soc 117: 10622-10628 (1995) | |||||||||
| Streptavadin(Y43A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -90.4 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(S27A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -103 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(N23E) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -108 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(N23A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -90.0 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavidin (126/127 > 99%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -104 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavidin (Y43F) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -115 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(Y43A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -66.9 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(S27A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -97.5 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(N23E) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -100 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavadin(N23A) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -75.3 | n/a | 7 | 25 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
| Streptavidin (126/127 > 99%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -102 | n/a | n/a | 25 | |
University of Washington | J Am Chem Soc 117: 10622-10628 (1995) | |||||||||
| Streptavadin(W79F) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -109 | n/a | n/a | 25.3 | |
University of Washington | J Am Chem Soc 117: 10622-10628 (1995) | |||||||||
| Streptavadin(W108F) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -98.2 | n/a | n/a | 25.2 | |
University of Washington | J Am Chem Soc 117: 10622-10628 (1995) | |||||||||
| Streptavidin (Y43F) (125/127 = 98%)† (Streptomyces avidinii) | BDBM12 (5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]im...) | GoogleScholar PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | n/a | n/a | -118 | n/a | 7 | 37 | |
University of Washington | Biochemistry 37: 7657-63 (1998) | |||||||||
