Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kinesin-like protein KIF11 (359/359 = 100%)† (Homo sapiens (Human)) | BDBM50198309 ((S)-4-(3-Hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay... | Bioorg Med Chem Lett 15: 2041-5 (2005) Article DOI: 10.1016/j.bmcl.2005.02.055 BindingDB Entry DOI: 10.7270/Q2ST7PCW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Kinesin-like protein KIF11 (359/359 = 100%)† (Homo sapiens (Human)) | BDBM50198309 ((S)-4-(3-Hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of KSP | Bioorg Med Chem Lett 17: 722-6 (2007) Article DOI: 10.1016/j.bmcl.2006.10.083 BindingDB Entry DOI: 10.7270/Q2HT2Q4S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Kinesin-like protein KIF11 (359/359 = 100%)† (Homo sapiens (Human)) | BDBM50198309 ((S)-4-(3-Hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 2.07E+4 | n/a | n/a | n/a | n/a | 6.8 | 25 |
University of Leipzig | Assay Description The ATPase activity of the Eg5 motor domain was measured by using the malachite green assay. | Chembiochem 6: 2005-13 (2005) Article DOI: 10.1002/cbic.200500168 BindingDB Entry DOI: 10.7270/Q2XW4HB5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |