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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Serine protease 1 (243/243 = 100%)† (Bos taurus (bovine)) | BDBM772 (Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet  | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | 4.80E+3 | -30.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Serine protease 1 (243/243 = 100%)† (Bos taurus (bovine)) | BDBM772 (Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | 2.10E+4 | -26.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
Axys Pharmaceutical | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | Chem Biol 7: 299-312 (2000) Article DOI: 10.1016/S1074-5521(00)00104-6 BindingDB Entry DOI: 10.7270/Q2NG4NWC | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Serine protease 1 (243/243 = 100%)† (Bos taurus (bovine)) | BDBM772 (Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | 3.90E+4 | -25.2 | n/a | n/a | n/a | n/a | n/a | 8.0 | 25 |
Max-Planck-Institut fuer Biochemie | Assay Description The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t... | J Mol Biol 301: 465-75 (2000) Article DOI: 10.1006/jmbi.2000.3966 BindingDB Entry DOI: 10.7270/Q2445JRM | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kJ/mole | -TΔS° kJ/mole | ΔH° kJ/mole | log K | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|
| Trypsin (243/243 = 100%)† (Bos taurus (bovine)) | BDBM772 (Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...) | DrugBank GoogleScholar KEGG PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -26.9 | -9.91 | -17 | 4.79 | 8 | 20.1 | |
University of Groningen | J Am Chem Soc 125: 10570-9 (2003) | |||||||||
| Trypsin (243/243 = 100%)† (Bos taurus (bovine)) | BDBM772 (Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...) | DrugBank GoogleScholar KEGG PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -26.7 | -5.40 | -21.4 | 4.61 | 8 | 30 | |
University of Groningen | J Am Chem Soc 125: 10570-9 (2003) | |||||||||
| Trypsin (243/243 = 100%)† (Bos taurus (bovine)) | BDBM772 (Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...) | DrugBank GoogleScholar KEGG PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -26.7 | -3.01 | -23.7 | 4.49 | 8 | 37.1 | |
University of Groningen | J Am Chem Soc 125: 10570-9 (2003) | |||||||||
| Trypsin (243/243 = 100%)† (Bos taurus (bovine)) | BDBM772 (Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...) | DrugBank GoogleScholar KEGG PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -26.6 | -7.69 | -18.9 | 4.65 | 8 | 25.1 | |
University of Groningen | J Am Chem Soc 125: 10570-9 (2003) | |||||||||
| Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kJ/mole | -TΔS° kJ/mole | ΔH° kJ/mole | log K | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|
| Trypsin (243/243 = 100%)† (Bos taurus (bovine)) | BDBM772 (Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...) | DrugBank GoogleScholar KEGG PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -26.9 | -9.91 | -17 | 4.79 | 8 | 20.1 | |
University of Groningen | J Am Chem Soc 125: 10570-9 (2003) | |||||||||
| Trypsin (243/243 = 100%)† (Bos taurus (bovine)) | BDBM772 (Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...) | DrugBank GoogleScholar KEGG PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -26.7 | -5.40 | -21.4 | 4.61 | 8 | 30 | |
University of Groningen | J Am Chem Soc 125: 10570-9 (2003) | |||||||||
| Trypsin (243/243 = 100%)† (Bos taurus (bovine)) | BDBM772 (Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...) | DrugBank GoogleScholar KEGG PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -26.7 | -3.01 | -23.7 | 4.49 | 8 | 37.1 | |
University of Groningen | J Am Chem Soc 125: 10570-9 (2003) | |||||||||
| Trypsin (243/243 = 100%)† (Bos taurus (bovine)) | BDBM772 (Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...) | DrugBank GoogleScholar KEGG PDB | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -26.6 | -7.69 | -18.9 | 4.65 | 8 | 25.1 | |
University of Groningen | J Am Chem Soc 125: 10570-9 (2003) | |||||||||
