Found 4 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)Show InChI InChI=1S/C17H19N5S/c1-11-16(23-12(2)19-11)15-9-10-18-17(21-15)20-13-5-7-14(8-6-13)22(3)4/h5-10H,1-4H3,(H,18,20,21) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 220 | -38.6 | n/a | n/a | n/a | n/a | n/a | n/a | 30 |
Cyclacel Limited
| Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P... |
J Med Chem 47: 1662-75 (2004)
Article DOI: 10.1021/jm0309957 BindingDB Entry DOI: 10.7270/Q2H993DD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-dependent kinase 2
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)Show InChI InChI=1S/C17H19N5S/c1-11-16(23-12(2)19-11)15-9-10-18-17(21-15)20-13-5-7-14(8-6-13)22(3)4/h5-10H,1-4H3,(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| 251 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cyclacel Ltd.
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
J Med Chem 53: 4367-78 (2010)
Article DOI: 10.1021/jm901913s BindingDB Entry DOI: 10.7270/Q2930T9D |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A2/Cyclin-dependent kinase 2
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)Show InChI InChI=1S/C17H19N5S/c1-11-16(23-12(2)19-11)15-9-10-18-17(21-15)20-13-5-7-14(8-6-13)22(3)4/h5-10H,1-4H3,(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Cyclacel Ltd
| Assay Description In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2. |
Chem Biol 13: 201-11 (2006)
Article DOI: 10.1016/j.chembiol.2005.11.011 BindingDB Entry DOI: 10.7270/Q2542M16 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-dependent kinase 2
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM8066
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)Show InChI InChI=1S/C17H19N5S/c1-11-16(23-12(2)19-11)15-9-10-18-17(21-15)20-13-5-7-14(8-6-13)22(3)4/h5-10H,1-4H3,(H,18,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Cyclacel Ltd
| Assay Description In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2. |
Chem Biol 13: 201-11 (2006)
Article DOI: 10.1016/j.chembiol.2005.11.011 BindingDB Entry DOI: 10.7270/Q2542M16 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |