Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (308/361 = 85%)† (Homo sapiens (Human)) | BDBM14360 ((-)-1 | (R)-(-)-3-{2-[(3-cyclopropyloxy-4-diflurom...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | 7.5 | 22 |
University of North Carolina at Chapel Hill | Assay Description PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c... | J Med Chem 49: 1867-73 (2006) Article DOI: 10.1021/jm051273d BindingDB Entry DOI: 10.7270/Q2MK6B48 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (361/361 = 100%)† (Homo sapiens (Human)) | BDBM14360 ((-)-1 | (R)-(-)-3-{2-[(3-cyclopropyloxy-4-diflurom...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | 7.5 | 22 |
University of North Carolina at Chapel Hill | Assay Description PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c... | J Med Chem 49: 1867-73 (2006) Article DOI: 10.1021/jm051273d BindingDB Entry DOI: 10.7270/Q2MK6B48 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |