Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nitric oxide synthase, inducible (369/425 = 87%)† (Mus musculus (mouse)) | BDBM50055281 (2-Ethyl-isothiourea | CHEMBL321691 | ETHYLISOTHIOU...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University Medical School Curated by ChEMBL | Assay Description Binding affinity against mouse Inducible nitric oxide synthase (iNOS) | J Med Chem 39: 5110-8 (1997) Article DOI: 10.1021/jm960481q BindingDB Entry DOI: 10.7270/Q29W0DKZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nitric oxide synthase, inducible (431/431 = 100%)† (Homo sapiens (Human)) | BDBM50055281 (2-Ethyl-isothiourea | CHEMBL321691 | ETHYLISOTHIOU...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University Medical School Curated by ChEMBL | Assay Description The compound was evaluated for the inhibitory potencies using human Inducible nitric oxide synthase (hiNOS) | J Med Chem 39: 5110-8 (1997) Article DOI: 10.1021/jm960481q BindingDB Entry DOI: 10.7270/Q29W0DKZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |