Found 3 hits Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
3-phosphoinositide-dependent protein kinase 1
(312/312 = 100%)†
(Homo sapiens (Human)) | BDBM19087
(15,16-dimethoxy-6-methyl-8,12-diazatetracyclo[8.8....)Show InChI InChI=1S/C19H18N4O2/c1-9-13(20)5-4-10-17-11-6-15(24-2)16(25-3)7-14(11)22-8-12(17)19(21)23-18(9)10/h4-8H,20H2,1-3H3,(H2,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
A homogeneous in vitro assay based on a LANCE format was first used for high-throughput screening. Those compounds that showed the largest different... |
J Med Chem 50: 5547-9 (2007)
Article DOI: 10.1021/jm070851i
BindingDB Entry DOI: 10.7270/Q2639N0S |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
3-phosphoinositide-dependent protein kinase 1
(312/312 = 100%)†
(Homo sapiens (Human)) | BDBM19087
(15,16-dimethoxy-6-methyl-8,12-diazatetracyclo[8.8....)Show InChI InChI=1S/C19H18N4O2/c1-9-13(20)5-4-10-17-11-6-15(24-2)16(25-3)7-14(11)22-8-12(17)19(21)23-18(9)10/h4-8H,20H2,1-3H3,(H2,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of PDK1 (unknown origin) |
J Med Chem 56: 2726-37 (2013)
Article DOI: 10.1021/jm4000227
BindingDB Entry DOI: 10.7270/Q24Q7WCF |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
3-phosphoinositide-dependent protein kinase 1
(312/312 = 100%)†
(Homo sapiens (Human)) | BDBM19087
(15,16-dimethoxy-6-methyl-8,12-diazatetracyclo[8.8....)Show InChI InChI=1S/C19H18N4O2/c1-9-13(20)5-4-10-17-11-6-15(24-2)16(25-3)7-14(11)22-8-12(17)19(21)23-18(9)10/h4-8H,20H2,1-3H3,(H2,21,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human GST-tagged-PDK1 expressed in HEK293 cells |
Eur J Med Chem 45: 1379-86 (2010)
Article DOI: 10.1016/j.ejmech.2009.12.036
BindingDB Entry DOI: 10.7270/Q2HD7VT5 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
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