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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hematopoietic prostaglandin D synthase (199/199 = 100%)† (Homo sapiens (Human)) | BDBM21615 (1-phenyl-1H-pyrazole-4-carboxylic acid | Pyrazole,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB Article PubMed | n/a | n/a | 8.90E+5 | n/a | n/a | n/a | n/a | 7.2 | 22 |
AstraZeneca | Assay Description The PGDS glutathione-S-transferase (GST) activity was measured by using MonoChloroBimane (MCB) as a chromogenic substrate. The assay was run at 384-w... | J Med Chem 51: 2178-86 (2008) Article DOI: 10.1021/jm701509k BindingDB Entry DOI: 10.7270/Q2Z036FR | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Hematopoietic prostaglandin D synthase (199/199 = 100%)† (Homo sapiens (Human)) | BDBM21615 (1-phenyl-1H-pyrazole-4-carboxylic acid | Pyrazole,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB Article PubMed | n/a | n/a | n/a | 1.40E+5 | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Binding affinity to human HPGDS expressed in Escherichia coli by isothermal titration calorimetry | Bioorg Med Chem Lett 25: 2496-500 (2015) Article DOI: 10.1016/j.bmcl.2015.04.065 BindingDB Entry DOI: 10.7270/Q2J9683M | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
