Affinity Data by PDB ID

PDB code 2WOG

Identical Ligands in BindingDB

Found 17 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	50	-9.85	n/a	n/a	n/a	n/a	n/a	6.9	22
Institut de Biologie Structurale					Assay Description The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...				J Med Chem 51: 1115-25 (2008) Article DOI: 10.1021/jm070606z BindingDB Entry DOI: 10.7270/Q2DJ5CXD
Institut de Biologie Structurale					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	71.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Cancer Research Curated by ChEMBL					Assay Description Inhibition of C-terminal His6-tagged human Eg5 basal ATPase activity				J Med Chem 54: 1576-86 (2011) Article DOI: 10.1021/jm100991m BindingDB Entry DOI: 10.7270/Q2154HC9
Institute for Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	107	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Beatson Institute for Cancer Research Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain basal ATPase activity expressed in Escherichia coli BL21 (...				J Med Chem 56: 1878-93 (2013) Article DOI: 10.1021/jm3014597 BindingDB Entry DOI: 10.7270/Q20866NN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	129	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Beatson Institute for Cancer Research Curated by ChEMBL					Assay Description Inhibition of MT-stimulated human N-terminal His6-tagged Eg5 (1 to 368 amino acid residues) motor domain ATPase activity expressed in Escherichia col...				J Med Chem 56: 1878-93 (2013) Article DOI: 10.1021/jm3014597 BindingDB Entry DOI: 10.7270/Q20866NN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	136	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Beatson Institute for Cancer Research Curated by ChEMBL					Assay Description Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...				J Med Chem 55: 1511-25 (2012) Article DOI: 10.1021/jm201195m BindingDB Entry DOI: 10.7270/Q2CZ386T
					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	144	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Beatson Institute for Cancer Research Curated by ChEMBL					Assay Description Inhibition of N-terminal hexa-histidine tagged human cloned Eg5 (1 to 368 amino acids) expressed in Escherichia coli BL21 (DE3) assessed as reduction...				J Med Chem 55: 1511-25 (2012) Article DOI: 10.1021/jm201195m BindingDB Entry DOI: 10.7270/Q2CZ386T
					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Cairo University Curated by ChEMBL					Assay Description Inhibition of human Eg5 catalytic domain assessed as inhibition of microtubulin-induced ATPase activity after 25 mins by spectrophotometric analysis				Eur J Med Chem 62: 614-31 (2013) Article DOI: 10.1016/j.ejmech.2013.01.031 BindingDB Entry DOI: 10.7270/Q2KH0PP9
Cairo University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	186	n/a	n/a	n/a	n/a	n/a	n/a
University of Strathclyde Curated by ChEMBL					Assay Description Inhibition of basal ATPase activity of Eg5 by coupled pyruvate kinase/lactate dehydrogenase assay				Eur J Med Chem 54: 483-98 (2012) Article DOI: 10.1016/j.ejmech.2012.05.034 BindingDB Entry DOI: 10.7270/Q24B32C6
University of Strathclyde Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	285	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Cancer Research Curated by ChEMBL					Assay Description Inhibition of C-terminal His6-tagged human Eg5 microtubule-stimulated ATPase activity				J Med Chem 54: 1576-86 (2011) Article DOI: 10.1021/jm100991m BindingDB Entry DOI: 10.7270/Q2154HC9
Institute for Cancer Research Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	352	n/a	n/a	n/a	n/a	n/a	n/a
The Beatson Institute for Cancer Research Curated by ChEMBL					Assay Description Inhibition of microtubule-stimulated ATPase activity of N-terminal His-6-tagged human wild type Eg5 (1 to 368) expressed in Escherichia coli BL21 by ...				J Med Chem 56: 6317-29 (2013) Article DOI: 10.1021/jm4006274 BindingDB Entry DOI: 10.7270/Q2M32X5D
					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
New Mexico State University Curated by ChEMBL					Assay Description Inhibition of human recombinant microtubule-activated KSP motor domain ATPase activity after 10 mins by end-point assay				Bioorg Med Chem 19: 5446-53 (2011) Article DOI: 10.1016/j.bmc.2011.07.054 BindingDB Entry DOI: 10.7270/Q2KP82HC
New Mexico State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Alagappa University Curated by ChEMBL					Assay Description Inhibition of mitotic kinesin Eg5 (unknown origin)				Eur J Med Chem 148: 106-115 (2018) Article DOI: 10.1016/j.ejmech.2018.02.010 BindingDB Entry DOI: 10.7270/Q25141R9
Alagappa University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cairo University Curated by ChEMBL					Assay Description Inhibition of human Eg5 catalytic domain basal ATPase activity after 25 mins by spectrophotometric analysis				Eur J Med Chem 62: 614-31 (2013) Article DOI: 10.1016/j.ejmech.2013.01.031 BindingDB Entry DOI: 10.7270/Q2KH0PP9
Cairo University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Shizuoka Curated by ChEMBL					Assay Description Inhibition of Eg5 assessed as inhibition ATP hydrolysis by ATPase assay				Bioorg Med Chem Lett 17: 3921-4 (2007) Article DOI: 10.1016/j.bmcl.2007.04.101 BindingDB Entry DOI: 10.7270/Q2542N8R
University of Shizuoka Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Shizuoka Curated by ChEMBL					Assay Description Binding affinity against delta opioid receptor in mouse hot plate test				ACS Med Chem Lett 6: 1004-9 (2015) Article DOI: 10.1021/acsmedchemlett.5b00221 BindingDB Entry DOI: 10.7270/Q2WM1G76
University of Shizuoka Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 [1-973] (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Santiago de Compostela, Jenaro de la Fuente s/n, Campus Vida, Santiago de Compostela 15782 (Spain)					Assay Description The IC50 measurements were done using a microtubule-activated ATPase kinetic assay according to the manufacturer's instructions. Reactions were ...				Chembiochem 15: 1471-80 (2014) Article DOI: 10.1002/cbic.201402089 BindingDB Entry DOI: 10.7270/Q29W0D5K
					More data for this Ligand-Target Pair				3D Structure (crystal)
Kinesin-like protein KIF11 (368/368 = 100%)^† (Homo sapiens (Human))	BDBM23772 ((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a
New Mexico State University Curated by ChEMBL					Assay Description Inhibition of KSP in human HeLa cells assessed as bipolar spindle formation				Bioorg Med Chem 19: 5446-53 (2011) Article DOI: 10.1016/j.bmc.2011.07.054 BindingDB Entry DOI: 10.7270/Q2KP82HC
New Mexico State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output