Affinity Data by PDB ID

PDB code 2XFP

Identical Ligands in BindingDB

Found 20 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur Curated by ChEMBL					Assay Description Inhibition of MAO-B				J Med Chem 54: 5320-34 (2011) Article DOI: 10.1021/jm2006782 BindingDB Entry DOI: 10.7270/Q2RF5W11
University of Namur Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B [I199F] (519/520 > 99%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University					Assay Description MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...				J Biol Chem 280: 15761-6 (2005) Article DOI: 10.1074/jbc.M500949200 BindingDB Entry DOI: 10.7270/Q2DR2SP5
Emory University					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Padova Curated by ChEMBL					Assay Description Competitive inhibition of recombinant human MAO-B expressed in baculovirus infected BT1 cells using benzylamine as substrate at 200 uM preincubated f...				Eur J Med Chem 70: 88-101 (2013) Article DOI: 10.1016/j.ejmech.2013.07.005 BindingDB Entry DOI: 10.7270/Q2T156MV
University of Padova Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
North-West University Curated by ChEMBL					Assay Description Inhibition of human MAOB				Bioorg Med Chem 19: 4829-40 (2011) Article DOI: 10.1016/j.bmc.2011.06.070 BindingDB Entry DOI: 10.7270/Q2H41RTW
North-West University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kadir Has University Curated by ChEMBL					Assay Description Inhibition constant against human recombinant Monoamine oxidase-B				Bioorg Med Chem Lett 15: 4438-46 (2005) Article DOI: 10.1016/j.bmcl.2005.07.043 BindingDB Entry DOI: 10.7270/Q2KW5FKR
Kadir Has University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
North-West University Curated by ChEMBL					Assay Description Inhibition of recombinant wild-type MAOB from human liver expressed in Pichia pastoris				Bioorg Med Chem Lett 19: 2509-13 (2009) Article DOI: 10.1016/j.bmcl.2009.03.030 BindingDB Entry DOI: 10.7270/Q2C53KQB
North-West University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	3.00E+3	-31.5	n/a	n/a	n/a	n/a	n/a	7.5	25
Emory University					Assay Description MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...				J Biol Chem 280: 15761-6 (2005) Article DOI: 10.1074/jbc.M500949200 BindingDB Entry DOI: 10.7270/Q2DR2SP5
Emory University					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	5.34E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
North-West University Curated by ChEMBL					Assay Description Inhibition of human recombinant MAOB expressed in insect cells by fluorescence assay				Bioorg Med Chem 19: 261-74 (2011) Article DOI: 10.1016/j.bmc.2010.11.028 BindingDB Entry DOI: 10.7270/Q2DR2VSB
North-West University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (476/520 = 92%)^† (Bos taurus)	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	6.00E+3	-29.8	n/a	n/a	n/a	n/a	n/a	7.4	25
Emory University					Assay Description MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...				J Biol Chem 280: 15761-6 (2005) Article DOI: 10.1074/jbc.M500949200 BindingDB Entry DOI: 10.7270/Q2DR2SP5
Emory University					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Roma La Sapienza P.le Aldo Moro Curated by ChEMBL					Assay Description Inhibition of human recombinant MAO-B expressed in baculovirus infected BT1 cells				Bioorg Med Chem Lett 20: 6479-82 (2010) Article DOI: 10.1016/j.bmcl.2010.09.061 BindingDB Entry DOI: 10.7270/Q2HM59QH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
North-West University Curated by ChEMBL					Assay Description Inhibition of human recombinant MAOB expressed in insect cells by fluorescence assay				Bioorg Med Chem 19: 261-74 (2011) Article DOI: 10.1016/j.bmc.2010.11.028 BindingDB Entry DOI: 10.7270/Q2DR2VSB
North-West University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.88E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Roma Sapienza Curated by ChEMBL					Assay Description Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramin...				Eur J Med Chem 46: 4846-52 (2011) Article DOI: 10.1016/j.ejmech.2011.07.017 BindingDB Entry DOI: 10.7270/Q2QV3MXF
Universit£ degli Studi di Roma Sapienza Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.88E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza Curated by ChEMBL					Assay Description Inhibition of human recombinant MAOB expressed in baculovirus infected insect BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-t...				J Med Chem 53: 6516-20 (2010) Article DOI: 10.1021/jm100120s BindingDB Entry DOI: 10.7270/Q26H4HNW
					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.88E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Roma Curated by ChEMBL					Assay Description Inhibition of human recombinant MAOB				Eur J Med Chem 45: 800-4 (2010) Article DOI: 10.1016/j.ejmech.2009.11.003 BindingDB Entry DOI: 10.7270/Q2CR5TH5
Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.88E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza University of Rome Curated by ChEMBL					Assay Description Inhibition of human recombinant MAO-B expressed in baculovirus-infected BTI-TN-5B1-4 cell microsomes assessed as decrease in H2O2 production using p-...				Bioorg Med Chem 22: 2887-95 (2014) Article DOI: 10.1016/j.bmc.2014.03.042 BindingDB Entry DOI: 10.7270/Q2C53NCP
Sapienza University of Rome Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.88E+4	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Roma La Sapienza Curated by ChEMBL					Assay Description Inhibition of human MAOB by fluorimetry				Bioorg Med Chem 18: 5715-23 (2010) Article DOI: 10.1016/j.bmc.2010.06.007 BindingDB Entry DOI: 10.7270/Q25D8S19
					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.88E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Roma La Sapienza Curated by ChEMBL					Assay Description Inhibition of human MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate incubated for 15 mins prior to substrate...				Eur J Med Chem 58: 405-17 (2012) Article DOI: 10.1016/j.ejmech.2012.10.032 BindingDB Entry DOI: 10.7270/Q20G3M75
					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.88E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dipartimento di Chimica e Tecnologie del Farmaco Universit£ degli Studi di Roma La Sapienza Curated by ChEMBL					Assay Description Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyra...				Bioorg Med Chem 18: 5063-70 (2010) Article DOI: 10.1016/j.bmc.2010.05.070 BindingDB Entry DOI: 10.7270/Q22F7PD1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.11E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sapienza - Universit£ di Roma Curated by ChEMBL					Assay Description Inhibition of recombinant human MAO-B expressed in baculovirus infected BT1-TN-5B1-4 cells assessed as inhibition of production of hydrogen peroxide ...				Eur J Med Chem 59: 91-100 (2013) Article DOI: 10.1016/j.ejmech.2012.11.006 BindingDB Entry DOI: 10.7270/Q2T43VFR
Sapienza - Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Amine oxidase [flavin-containing] B (520/520 = 100%)^† (Homo sapiens (Human))	BDBM11022 (2,3-dihydro-1H-indole-2,3-dione \| CHEMBL326294 \| I...) Show SMILES O=C1Nc2ccccc2C1=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Roma Curated by ChEMBL					Assay Description Inhibition of human recombinant microsomal MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate assessed as reduc...				Eur J Med Chem 117: 292-300 (2016) Article DOI: 10.1016/j.ejmech.2016.03.081 BindingDB Entry DOI: 10.7270/Q2JW8GSP
Universit£ di Roma Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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Search BindingMOAD for More Affinity Data:

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output