Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nuclear receptor ROR-gamma (243/243 = 100%)† (Homo sapiens (Human)) | BDBM46355 (DIGOXIN | MLS000069819 | SMR000059217 | US10668094...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Inhibition of thymus-specific isoform RORgamma (unknown origin) transcriptional activity by luciferase-based cotransfection assay | J Med Chem 57: 5871-92 (2014) Article DOI: 10.1021/jm401901d BindingDB Entry DOI: 10.7270/Q2M0473Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor ROR-gamma (243/243 = 100%)† (Homo sapiens (Human)) | BDBM46355 (DIGOXIN | MLS000069819 | SMR000059217 | US10668094...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University School of Medicine Curated by ChEMBL | Assay Description Antagonist activity at transactivation domain of RORgammat (unknown origin) expressed in Drosophila Schneider cells co-expressing Gal4-DNA binding do... | ACS Med Chem Lett 4: 79-84 (2013) Article DOI: 10.1021/ml300286h BindingDB Entry DOI: 10.7270/Q29Z966N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor ROR-gamma (243/243 = 100%)† (Homo sapiens (Human)) | BDBM46355 (DIGOXIN | MLS000069819 | SMR000059217 | US10668094...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Displacement of fluorescein-labelled 25-HC from human RoRgamma-LBD by competitive binding assay | J Med Chem 57: 5871-92 (2014) Article DOI: 10.1021/jm401901d BindingDB Entry DOI: 10.7270/Q2M0473Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nuclear receptor ROR-gamma (243/243 = 100%)† (Homo sapiens (Human)) | BDBM46355 (DIGOXIN | MLS000069819 | SMR000059217 | US10668094...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 109 | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]25-hydroxycholesterol from human RORc-LBD expressed in bacterial expression system after 3 hrs by scintillation counting analysis | Bioorg Med Chem Lett 24: 5769-76 (2014) Article DOI: 10.1016/j.bmcl.2014.10.037 BindingDB Entry DOI: 10.7270/Q2125V8F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |