Found 3 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(610/610 = 100%)† (Homo sapiens (Human)) | BDBM24243
(2-amino-N-[4-(benzyloxy)phenyl]acetamide | Amino a...)Show InChI InChI=1S/C15H16N2O2/c16-10-15(18)17-13-6-8-14(9-7-13)19-11-12-4-2-1-3-5-12/h1-9H,10-11,16H2,(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences
Curated by ChEMBL
| Assay Description Inhibition of LTA4 hydrolase (unknown origin) by whole blood assay |
Bioorg Med Chem Lett 18: 3891-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.046 BindingDB Entry DOI: 10.7270/Q20P0ZTV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Leukotriene A-4 hydrolase
(610/610 = 100%)† (Homo sapiens (Human)) | BDBM24243
(2-amino-N-[4-(benzyloxy)phenyl]acetamide | Amino a...)Show InChI InChI=1S/C15H16N2O2/c16-10-15(18)17-13-6-8-14(9-7-13)19-11-12-4-2-1-3-5-12/h1-9H,10-11,16H2,(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Berlex Biosciences
| Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani... |
Bioorg Med Chem 16: 4963-83 (2008)
Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Leukotriene A-4 hydrolase
(610/610 = 100%)† (Homo sapiens (Human)) | BDBM24243
(2-amino-N-[4-(benzyloxy)phenyl]acetamide | Amino a...)Show InChI InChI=1S/C15H16N2O2/c16-10-15(18)17-13-6-8-14(9-7-13)19-11-12-4-2-1-3-5-12/h1-9H,10-11,16H2,(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences
Curated by ChEMBL
| Assay Description Inhibition of LTA4 hydrolase (unknown origin) by hydrolase assay |
Bioorg Med Chem Lett 18: 3891-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.046 BindingDB Entry DOI: 10.7270/Q20P0ZTV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |