Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (402/404 > 99%)† (Homo sapiens (Human)) | BDBM25361 (N-(4-{[4-(cyclohexylamino)-1-(3-fluorophenyl)-2-ox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | 4.5 | 22 |
Merck Research Laboratories | Assay Description The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. After the reaction was terminated, the solution wa... | J Med Chem 51: 6259-62 (2008) Article DOI: 10.1021/jm800914n BindingDB Entry DOI: 10.7270/Q2KS6PVK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |