Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bifunctional dihydrofolate reductase-thymidylate synthase (518/521 > 99%)† (Trypanosoma cruzi) | BDBM50320792 (CHEMBL1165388 | Ethyl4-(5-[(2,4-diamino-6-quinazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alabama Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay | Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (518/521 > 99%)† (Trypanosoma cruzi) | BDBM50320792 (CHEMBL1165388 | Ethyl4-(5-[(2,4-diamino-6-quinazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 5.68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alabama Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi DHFR by Lineweaver-Burk plot | Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Bifunctional dihydrofolate reductase-thymidylate synthase (518/521 > 99%)† (Trypanosoma cruzi) | BDBM50320792 (CHEMBL1165388 | Ethyl4-(5-[(2,4-diamino-6-quinazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 23.8 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alabama Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay | Bioorg Med Chem 18: 4056-66 (2010) Article DOI: 10.1016/j.bmc.2010.04.020 BindingDB Entry DOI: 10.7270/Q26110GG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |