Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (728/728 = 100%)† (Homo sapiens (Human)) | BDBM123780 (2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of human Dipeptidyl peptidase-4 expressed in Caco-2 cells using Gly-Pro-pNA.Tos as substrate after 60 mins by microplate reader analysis | Bioorg Med Chem 19: 4482-98 (2011) Article DOI: 10.1016/j.bmc.2011.06.032 BindingDB Entry DOI: 10.7270/Q2P26ZGN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dipeptidyl peptidase 4 (618/730 = 85%)† (Rattus norvegicus (rat)) | BDBM123780 (2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- ph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of DPP4 in rat plasma incubated for 60 mins using H-lys-Ala-pNA.2HCl substrate | Bioorg Med Chem 19: 4953-70 (2011) Article DOI: 10.1016/j.bmc.2011.06.059 BindingDB Entry DOI: 10.7270/Q2C53MVJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dipeptidyl peptidase 4 (728/728 = 100%)† (Homo sapiens (Human)) | BDBM123780 (2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University | Assay Description The HypoGen module in DS2.5 was employed to produce pharmaphores with the training set compounds. | Chem Biol Drug Des 84: 364-77 (2014) Article DOI: 10.1111/cbdd.12327 BindingDB Entry DOI: 10.7270/Q2D21W96 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dipeptidyl peptidase 4 (728/728 = 100%)† (Homo sapiens (Human)) | BDBM123780 (2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of human DPP4 isolated from from human CaCo2 cells incubated for 15 mins using Gly-Pro-pNA.Tos substrate | Bioorg Med Chem 19: 4953-70 (2011) Article DOI: 10.1016/j.bmc.2011.06.059 BindingDB Entry DOI: 10.7270/Q2C53MVJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dipeptidyl peptidase 4 (618/730 = 85%)† (Rattus norvegicus (rat)) | BDBM123780 (2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- ph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 6.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of DPP4 in rat spleen incubated for 60 mins using H-lys-Ala-pNA.2HCl substrate | Bioorg Med Chem 19: 4953-70 (2011) Article DOI: 10.1016/j.bmc.2011.06.059 BindingDB Entry DOI: 10.7270/Q2C53MVJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |