Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cyclin-dependent kinase 2 (298/298 = 100%)† (Homo sapiens (Human)) | BDBM7238 ((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai Curated by ChEMBL | Assay Description Inhibition of His-6-tagged CDK2 (unknown origin) expressed in baculovirus-infected insect cells using histone H1 as substrate after 1 hr by by liquid... | J Med Chem 57: 578-99 (2014) Article DOI: 10.1021/jm401073p BindingDB Entry DOI: 10.7270/Q28W3FSW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-dependent kinase 2 (298/298 = 100%)† (Homo sapiens (Human)) | BDBM7238 ((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Curated by ChEMBL | Assay Description Inhibition of CDK2 | AAPS J 8: 204-21 (2006) Article DOI: 10.1208/aapsj080125 BindingDB Entry DOI: 10.7270/Q2TX3GBS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (298/298 = 100%)† (Homo sapiens (Human)) | BDBM7238 ((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | 7.4 | 22 |
SUGEN, Inc. | Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i... | Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |