Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (358/361 > 99%)† (Homo sapiens (Human)) | BDBM50358828 (CHEMBL1922946) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Monash University (Parkville campus) Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE4D2 overexpressed in Escherichia coli after 15 mins using [3H]cAMP by scintillation proximity assay | Bioorg Med Chem Lett 21: 7089-93 (2011) Article DOI: 10.1016/j.bmcl.2011.09.109 BindingDB Entry DOI: 10.7270/Q2D21Z1F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |