Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Deoxyuridine 5'-triphosphate nucleotidohydrolase (173/173 = 100%)† (Plasmodium falciparum) | BDBM50190543 (1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum dUTPase | J Med Chem 49: 4183-95 (2006) Article DOI: 10.1021/jm060126s BindingDB Entry DOI: 10.7270/Q22J6BF0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Deoxyuridine 5'-triphosphate nucleotidohydrolase (173/173 = 100%)† (Plasmodium falciparum) | BDBM50173577 (1-{4-Hydroxy-5-[(trityl-amino)-methyl]-tetrahydro-...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cells | J Med Chem 48: 5942-54 (2005) Article DOI: 10.1021/jm050111e BindingDB Entry DOI: 10.7270/Q2Z320DG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Deoxyuridine 5'-triphosphate nucleotidohydrolase (173/173 = 100%)† (Plasmodium falciparum) | BDBM50190543 (1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wales Cardiff Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum dUTPase | Eur J Med Chem 44: 678-88 (2009) Article DOI: 10.1016/j.ejmech.2008.05.018 BindingDB Entry DOI: 10.7270/Q20K28CG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |