Affinity Data by PDB ID

PDB code 3U6H

Identical Ligands in BindingDB

Found 8 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hepatocyte growth factor receptor (304/304 = 100%)^† (Homo sapiens (Human))	BDBM50383191 (CHEMBL2031893) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (304/304 = 100%)^† (Homo sapiens (Human))	BDBM50383191 (CHEMBL2031893) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-Met (unknown origin)				Eur J Med Chem 83: 581-93 (2014) Article DOI: 10.1016/j.ejmech.2014.06.068 BindingDB Entry DOI: 10.7270/Q2R78GTF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (304/304 = 100%)^† (Homo sapiens (Human))	BDBM50383191 (CHEMBL2031893) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of c-Met (unknown origin)				Eur J Med Chem 64: 62-73 (2013) Article DOI: 10.1016/j.ejmech.2013.04.001 BindingDB Entry DOI: 10.7270/Q27082SZ
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (304/304 = 100%)^† (Homo sapiens (Human))	BDBM50383191 (CHEMBL2031893) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of c-Met (unknown origin)				Bioorg Med Chem 21: 2843-55 (2013) Article DOI: 10.1016/j.bmc.2013.04.013 BindingDB Entry DOI: 10.7270/Q25D8T6Z
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (304/304 = 100%)^† (Homo sapiens (Human))	BDBM50383191 (CHEMBL2031893) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met by HTRF assay				J Med Chem 55: 1868-97 (2012) Article DOI: 10.1021/jm201331s BindingDB Entry DOI: 10.7270/Q23B616C
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (304/304 = 100%)^† (Homo sapiens (Human))	BDBM50383191 (CHEMBL2031893) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met by HTRF assay				J Med Chem 55: 1868-97 (2012) Article DOI: 10.1021/jm201331s BindingDB Entry DOI: 10.7270/Q23B616C
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (304/304 = 100%)^† (Homo sapiens (Human))	BDBM50383191 (CHEMBL2031893) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay				J Med Chem 55: 1868-97 (2012) Article DOI: 10.1021/jm201331s BindingDB Entry DOI: 10.7270/Q23B616C
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (304/304 = 100%)^† (Homo sapiens (Human))	BDBM50383191 (CHEMBL2031893) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of HGF-mediated c-met autophosphorylation in serum-starved human PC3 cells after 1 hr by electrochemiluminescent immunoassay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output