Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (734/734 = 100%)† (Homo sapiens (Human)) | BDBM123776 ((2S)-1-(2-{[(1r,3s,5R,7S)-3-hydroxyadamantan-1- yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University | Assay Description The HypoGen module in DS2.5 was employed to produce pharmaphores with the training set compounds. | Chem Biol Drug Des 84: 364-77 (2014) Article DOI: 10.1111/cbdd.12327 BindingDB Entry DOI: 10.7270/Q2D21W96 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dipeptidyl peptidase 4 (622/736 = 85%)† (Rattus norvegicus (rat)) | BDBM126821 (US8785477, Vildagliptin) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 80.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd. US Patent | Assay Description Thoroughly mixed test compounds, enzyme and reaction buffer, preincubated the mixture for 15 minutes at 37° C. and then primed reaction by adding sub... | US Patent US8785477 (2014) BindingDB Entry DOI: 10.7270/Q20K278Q | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |