Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D-amino-acid oxidase (347/347 = 100%)† (Homo sapiens (Human)) | BDBM50431079 (CHEMBL2338785 | US10202399, Example 9 | US9180122,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant DAAO after 30 mins by plate reader analysis | J Med Chem 56: 3582-92 (2013) Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D-amino-acid oxidase (347/347 = 100%)† (Homo sapiens (Human)) | BDBM50431079 (CHEMBL2338785 | US10202399, Example 9 | US9180122,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited US Patent | Assay Description The DAAO inhibitory activity was measured by assaying the amount of hydrogen peroxide (H2O2) produced by reacting DAAO protein with flavin adenine di... | US Patent US10202399 (2019) BindingDB Entry DOI: 10.7270/Q2542QQD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D-amino-acid oxidase (347/347 = 100%)† (Homo sapiens (Human)) | BDBM50431079 (CHEMBL2338785 | US10202399, Example 9 | US9180122,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Takeda Pharmaceutical Company Limited US Patent | Assay Description The DAAO inhibitory activity was measured by assaying the amount of hydrogen peroxide (H2O2) produced by reacting DAAO protein with flavin adenine di... | US Patent US9212147 (2015) BindingDB Entry DOI: 10.7270/Q29G5KKS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D-amino-acid oxidase (347/347 = 100%)† (Homo sapiens (Human)) | BDBM50431079 (CHEMBL2338785 | US10202399, Example 9 | US9180122,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of DAAO (unknown origin) by cell based assay | J Med Chem 56: 3582-92 (2013) Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D-amino-acid oxidase (347/347 = 100%)† (Homo sapiens (Human)) | BDBM50431079 (CHEMBL2338785 | US10202399, Example 9 | US9180122,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Takeda Pharmaceutical Company Limited US Patent | Assay Description This test was performed by partially modifying the method of Philip et. al. (J. Biomol. Screen. Vol. 11, pp 481-487, 2006). HEK293 cells that stably ... | US Patent US9212147 (2015) BindingDB Entry DOI: 10.7270/Q29G5KKS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D-amino-acid oxidase (347/347 = 100%)† (Homo sapiens (Human)) | BDBM50431079 (CHEMBL2338785 | US10202399, Example 9 | US9180122,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited US Patent | Assay Description The functional activity of compounds inhibiting the DAAO enzyme was determined by utilizing the co-product of the catalysis of D-Serine, H2O2 which c... | US Patent US9180122 (2015) BindingDB Entry DOI: 10.7270/Q2FT8JTB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |