Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Casein kinase I isoform gamma-2 (294/331 = 89%)† (Homo sapiens (Human)) | BDBM124350 (CHEMBL2071607 | US8759532, 1) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 6.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of CK1gamma2 expressed in HEK293 cells assessed as inhibition of LRP6 Thr1479 phosphorylation by immunoblotting | Bioorg Med Chem Lett 22: 5392-5 (2012) Article DOI: 10.1016/j.bmcl.2012.07.046 BindingDB Entry DOI: 10.7270/Q2CF9R6Q | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |