Search and Browse
Download
Enter Data
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Endothelial PAS domain-containing protein 1 (111/112 > 99%)† (Homo sapiens (Human)) | BDBM50426208 (CHEMBL2311933) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Peloton Therapeutics, Inc. Curated by ChEMBL | Assay Description Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assay | J Med Chem 61: 9691-9721 (2018) Article DOI: 10.1021/acs.jmedchem.8b01196 BindingDB Entry DOI: 10.7270/Q2H997RJ | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Endothelial PAS domain-containing protein 1 (111/112 > 99%)† (Homo sapiens (Human)) | BDBM50426208 (CHEMBL2311933) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a |
University of Texas Southwestern Medical Center Curated by ChEMBL | Assay Description Binding affinity to wild type PAS-B domain of HIF-2alpha (unknown origin) by isothermal calorimetry analysis | J Med Chem 56: 1739-47 (2013) Article DOI: 10.1021/jm301847z BindingDB Entry DOI: 10.7270/Q2BZ67CG | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
