Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Focal adhesion kinase 1 (279/279 = 100%)† (Homo sapiens (Human)) | BDBM50425675 (CHEMBL2315579) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 195 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono Research Curated by ChEMBL | Assay Description Inhibition of FAK (unknown origin) using biotinylated His-TEV-hsFAK(31-686)(K454R) substrate after 2 hrs by scintillation counting analysis | J Med Chem 56: 1160-70 (2013) Article DOI: 10.1021/jm3016014 BindingDB Entry DOI: 10.7270/Q2GT5PGP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Focal adhesion kinase 1 (279/279 = 100%)† (Homo sapiens (Human)) | BDBM50425675 (CHEMBL2315579) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono Research Curated by ChEMBL | Assay Description Inhibition of FAK in human HT-29 cells assessed as phosphorylation at tyrosine 397 after 45 mins | J Med Chem 56: 1160-70 (2013) Article DOI: 10.1021/jm3016014 BindingDB Entry DOI: 10.7270/Q2GT5PGP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Focal adhesion kinase 1 (279/279 = 100%)† (Homo sapiens (Human)) | BDBM50425675 (CHEMBL2315579) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a |
Merck Serono Research Curated by ChEMBL | Assay Description Binding affinity to FAK (unknown origin) by surface plasmon resonance analysis | J Med Chem 56: 1160-70 (2013) Article DOI: 10.1021/jm3016014 BindingDB Entry DOI: 10.7270/Q2GT5PGP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |