Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nicotinamide phosphoribosyltransferase (491/491 = 100%)† (Homo sapiens (Human)) | BDBM50438986 (CHEMBL2419503) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc Curated by ChEMBL | Assay Description Inhibition of human NAMPT using NAM/PRPP as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by mass spectrometric ... | Bioorg Med Chem Lett 23: 4875-85 (2013) Article DOI: 10.1016/j.bmcl.2013.06.090 BindingDB Entry DOI: 10.7270/Q25T3MWP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nicotinamide phosphoribosyltransferase (491/491 = 100%)† (Homo sapiens (Human)) | BDBM50438986 (CHEMBL2419503) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc. Curated by ChEMBL | Assay Description Inhibition of Nampt (unknown origin) using nicotinamide as substrate preincubated for 15 mins measured after 30 mins by mass spectrometry analysis | Bioorg Med Chem Lett 24: 337-43 (2013) Article DOI: 10.1016/j.bmcl.2013.11.006 BindingDB Entry DOI: 10.7270/Q2CJ8FZH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nicotinamide phosphoribosyltransferase (491/491 = 100%)† (Homo sapiens (Human)) | BDBM50438986 (CHEMBL2419503) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc. Curated by ChEMBL | Assay Description Inhibition of C-terminal His-tagged NAMPT (unknown origin) expressed in Escherichia coli BL21 using nicotinamide as substrate preincubated for 15 min... | J Med Chem 56: 6413-33 (2013) Article DOI: 10.1021/jm4008664 BindingDB Entry DOI: 10.7270/Q2H996MB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |