Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoic acid receptor RXR-alpha (231/231 = 100%)† (Homo sapiens (Human)) | BDBM50018001 (CHEMBL3289659) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 1.86E+3 | n/a | n/a | n/a | n/a | n/a |
University of Alabama at Birmingham Curated by ChEMBL | Assay Description Agonist activity at human RXR-alpha-ligand binding domain homodimers assessed as coactivator recruitment by measuring GRIP1 binding to receptor by is... | J Med Chem 57: 5370-80 (2014) Article DOI: 10.1021/jm5004792 BindingDB Entry DOI: 10.7270/Q2183821 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Retinoic acid receptor RXR-alpha (230/231 > 99%)† (RAT) | BDBM50018001 (CHEMBL3289659) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
University of Alabama at Birmingham Curated by ChEMBL | Assay Description Agonist activity at RXR-alpha in rat R3KE cells infected with oncogene KLF4-ER assessed as inhibition of KLF4-mediated oncogenic transformation | J Med Chem 57: 5370-80 (2014) Article DOI: 10.1021/jm5004792 BindingDB Entry DOI: 10.7270/Q2183821 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Retinoic acid receptor RXR-alpha (231/231 = 100%)† (Homo sapiens (Human)) | BDBM50018001 (CHEMBL3289659) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
University of Alabama at Birmingham Curated by ChEMBL | Assay Description Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after ... | J Med Chem 57: 5370-80 (2014) Article DOI: 10.1021/jm5004792 BindingDB Entry DOI: 10.7270/Q2183821 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Retinoic acid receptor RXR-alpha (231/231 = 100%)† (Homo sapiens (Human)) | BDBM50018001 (CHEMBL3289659) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a |
University of Alabama at Birmingham Curated by ChEMBL | Assay Description Binding affinity to human RXR-alpha-ligand binding domain homodimers by fluorescence quenching method | J Med Chem 57: 5370-80 (2014) Article DOI: 10.1021/jm5004792 BindingDB Entry DOI: 10.7270/Q2183821 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |