Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hepatocyte growth factor receptor (292/292 = 100%)† (Homo sapiens (Human)) | BDBM50065456 (CHEMBL3402741) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono Research& Development Curated by ChEMBL | Assay Description Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assay | Bioorg Med Chem Lett 25: 1597-602 (2015) Article DOI: 10.1016/j.bmcl.2015.02.002 BindingDB Entry DOI: 10.7270/Q2HX1FBT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (292/292 = 100%)† (Homo sapiens (Human)) | BDBM50065456 (CHEMBL3402741) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono Research& Development Curated by ChEMBL | Assay Description Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assay | Bioorg Med Chem Lett 25: 1597-602 (2015) Article DOI: 10.1016/j.bmcl.2015.02.002 BindingDB Entry DOI: 10.7270/Q2HX1FBT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |