Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Farnesyl pyrophosphate synthase (348/348 = 100%)† (Homo sapiens (Human)) | BDBM97430 (50460, 14 | BPH-1358) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Urbana-Champaign Curated by ChEMBL | Assay Description Inhibition of human FPPS pre-incubated for 30 mins using GPP and IPP by continuous spectrophotometric assay | ACS Med Chem Lett 6: 349-54 (2015) Article DOI: 10.1021/ml500528x BindingDB Entry DOI: 10.7270/Q2251KW1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Farnesyl pyrophosphate synthase (348/348 = 100%)† (Homo sapiens (Human)) | BDBM97430 (50460, 14 | BPH-1358) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of California San Diego | Assay Description Human FPPS was expressed and purified and inhibition assays carried out as described previously. | Chem Biol Drug Des 81: 742-8 (2013) Article DOI: 10.1111/cbdd.12121 BindingDB Entry DOI: 10.7270/Q29S1PPZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |