Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-dependent kinase 6 (326/326 = 100%)† (Homo sapiens (Human)) | BDBM50001584 (CHEMBL3237442 | US8841312, 1) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc. US Patent | Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... | US Patent US8841312 (2014) BindingDB Entry DOI: 10.7270/Q2H41Q4H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |