Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50012632 (CHEMBL2333941) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 173 | n/a | n/a | n/a | n/a | n/a | n/a |
The City University of New York (CUNY) Curated by ChEMBL | Assay Description Inhibition of BACE 1 (unknown origin) using 250 nM of Rh-EVNLDAEFK-Quencher as substrate after 1 hr by FRET assay | Bioorg Med Chem 26: 4823-4840 (2018) Article DOI: 10.1016/j.bmc.2018.08.019 BindingDB Entry DOI: 10.7270/Q29S1TK8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50012632 (CHEMBL2333941) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 239 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of human BACE1 | J Med Chem 61: 4476-4504 (2018) Article DOI: 10.1021/acs.jmedchem.8b00246 BindingDB Entry DOI: 10.7270/Q23J3GJ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50012632 (CHEMBL2333941) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee Curated by ChEMBL | Assay Description Inhibition of human BACE-1 | J Med Chem 61: 619-637 (2018) Article DOI: 10.1021/acs.jmedchem.7b00393 BindingDB Entry DOI: 10.7270/Q2MP55P1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50012632 (CHEMBL2333941) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Inhibition of IgG1 Fc-fused human recombinant BACE1 (1 to 460 residues) expressed in HEK293 cells using methylcoumarin peptide harboring Swedish muta... | ACS Med Chem Lett 7: 271-6 (2016) Article DOI: 10.1021/acsmedchemlett.5b00432 BindingDB Entry DOI: 10.7270/Q2NS0WTZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50012632 (CHEMBL2333941) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Inhibition of recombinant human BACE1 by 7-methoxycoumarin-4-yl-acetyl-based FRET assay | Bioorg Med Chem Lett 24: 2033-45 (2014) Article DOI: 10.1016/j.bmcl.2014.03.025 BindingDB Entry DOI: 10.7270/Q2H41T0Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50012632 (CHEMBL2333941) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Inhibition of BACE1 in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta 40 or amyloid beta 42 production incuba... | ACS Med Chem Lett 7: 271-6 (2016) Article DOI: 10.1021/acsmedchemlett.5b00432 BindingDB Entry DOI: 10.7270/Q2NS0WTZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50012632 (CHEMBL2333941) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Inhibition of human recombinant BACE1 using MBP-C125Swe as substrate | Bioorg Med Chem Lett 26: 5729-5731 (2016) Article DOI: 10.1016/j.bmcl.2016.10.055 BindingDB Entry DOI: 10.7270/Q2W66NRR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50012632 (CHEMBL2333941) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee Curated by ChEMBL | Assay Description Inhibition of BACE-1 in HEK293 cells expressing human APP751 cDNA harboring N670L671 mutation pretreated for 2 hrs followed by measuring after 2 hrs ... | J Med Chem 61: 619-637 (2018) Article DOI: 10.1021/acs.jmedchem.7b00393 BindingDB Entry DOI: 10.7270/Q2MP55P1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50012632 (CHEMBL2333941) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Huazhong University of Science and Technology Curated by ChEMBL | Assay Description Inhibition of human BACE1 using MOCA-SEV-NL-DAEFR-DNP-RR as substrate measured after 2 hrs by FRET assay | J Nat Prod 81: 1937-1945 (2018) Article DOI: 10.1021/acs.jnatprod.7b01050 BindingDB Entry DOI: 10.7270/Q2R78HV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50012632 (CHEMBL2333941) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
Janssen Research and Development Curated by ChEMBL | Assay Description Inhibition of BACE1 in HEK293 cells expressing APPswedish mutant assessed as inhibition of amyloid beta production by ELISA | Bioorg Med Chem Lett 24: 2033-45 (2014) Article DOI: 10.1016/j.bmcl.2014.03.025 BindingDB Entry DOI: 10.7270/Q2H41T0Z | |||||||||||
More data for this Ligand-Target Pair |