Affinity Data by PDB ID

PDB code 1I10

Identical Ligands in BindingDB

Found 7 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
L-lactate dehydrogenase A chain (331/331 = 100%)^† (Homo sapiens (Human))	BDBM23222 (Oxalamic acid \| Oxamate \| Oxamate, 3 \| Oxamidic Ac...) Show SMILES NC(=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human LDH-A				J Med Chem 56: 1023-40 (2013) Article DOI: 10.1021/jm3014844 BindingDB Entry DOI: 10.7270/Q2QC04TB
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
L-lactate dehydrogenase A chain (331/331 = 100%)^† (Homo sapiens (Human))	BDBM23222 (Oxalamic acid \| Oxamate \| Oxamate, 3 \| Oxamidic Ac...) Show SMILES NC(=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute-CRO Curated by ChEMBL					Assay Description Competitive inhibition of human LDH5 in presence of NADH				J Med Chem 59: 487-96 (2016) Article DOI: 10.1021/acs.jmedchem.5b00168 BindingDB Entry DOI: 10.7270/Q2B27X41
National Cancer Institute-CRO Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
L-lactate dehydrogenase A chain (331/331 = 100%)^† (Homo sapiens (Human))	BDBM23222 (Oxalamic acid \| Oxamate \| Oxamate, 3 \| Oxamidic Ac...) Show SMILES NC(=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	1.38E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita` di Pisa Curated by ChEMBL					Assay Description Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to control				J Med Chem 54: 1599-612 (2011) Article DOI: 10.1021/jm101007q BindingDB Entry DOI: 10.7270/Q2J38SVC
Universita` di Pisa Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
L-lactate dehydrogenase A chain (331/331 = 100%)^† (Homo sapiens (Human))	BDBM23222 (Oxalamic acid \| Oxamate \| Oxamate, 3 \| Oxamidic Ac...) Show SMILES NC(=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	1.38E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chongqing University Curated by ChEMBL					Assay Description Inhibition of human LDHA using pyruvate as substrate assessed as disappearance of NADH				Bioorg Med Chem Lett 26: 72-5 (2016) Article DOI: 10.1016/j.bmcl.2015.11.025 BindingDB Entry DOI: 10.7270/Q2X63R09
Chongqing University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
L-lactate dehydrogenase A chain (331/331 = 100%)^† (Homo sapiens (Human))	BDBM23222 (Oxalamic acid \| Oxamate \| Oxamate, 3 \| Oxamidic Ac...) Show SMILES NC(=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	5.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli using pyruvate as substrate after 10 mins b...				Bioorg Med Chem Lett 23: 3186-94 (2013) Article DOI: 10.1016/j.bmcl.2013.04.001 BindingDB Entry DOI: 10.7270/Q29C6ZTT
Genentech Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
L-lactate dehydrogenase A chain (331/331 = 100%)^† (Homo sapiens (Human))	BDBM23222 (Oxalamic acid \| Oxamate \| Oxamate, 3 \| Oxamidic Ac...) Show SMILES NC(=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	5.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assay				Bioorg Med Chem Lett 24: 3764-71 (2014) Article DOI: 10.1016/j.bmcl.2014.06.076 BindingDB Entry DOI: 10.7270/Q2445P46
Genentech Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
L-lactate dehydrogenase A chain (311/331 = 94%)^† (Mus musculus (Mouse))	BDBM23222 (Oxalamic acid \| Oxamate \| Oxamate, 3 \| Oxamidic Ac...) Show SMILES NC(=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
Instituto Polit�cnico Nacional					Assay Description Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a...				J Enzyme Inhib Med Chem 26: 579-86 (2011) Article DOI: 10.3109/14756366.2011.566221 BindingDB Entry DOI: 10.7270/Q2R78D36
Instituto Polit�cnico Nacional					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output