Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Reverse transcriptase/RNaseH (545/555 = 98%)† (Human immunodeficiency virus 1) | BDBM33411 (β-Thujaplicinol | hydroxytropolone, 3) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 660 | n/a | n/a | n/a | n/a | 8.0 | 20 |
Gilead Sciences Inc. | Assay Description Enzyme activity was measuring substrate hydrolysis of RNase H. The intact substrate has a low background fluorescent signal and provides up to 50-fol... | J Med Chem 52: 5781-4 (2009) Article DOI: 10.1021/jm900597q BindingDB Entry DOI: 10.7270/Q2TM78F2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Reverse transcriptase/RNaseH (545/555 = 98%)† (Human immunodeficiency virus 1) | BDBM33411 (β-Thujaplicinol | hydroxytropolone, 3) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of HIV-1 BH10 reverse transcriptase RNase H activity expressed in Escherichia coli using [32P]-labeled template primer 31Trna/21P as subst... | Eur J Med Chem 155: 714-724 (2018) Article DOI: 10.1016/j.ejmech.2018.06.036 BindingDB Entry DOI: 10.7270/Q2571FKZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gag-Pol polyprotein (548/555 = 99%)† (Human immunodeficiency virus type 1 group M subtyp...) | BDBM33411 (β-Thujaplicinol | hydroxytropolone, 3) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | 7.8 | 37 |
McGill University | Assay Description To compare activity and inhibition of E. coli RNase H with HIV-1 RNase H, theconcentration of the E. coli was adjusted to the efficiency of 500 nM HI... | J Biol Chem 289: 16270-7 (2014) Article DOI: 10.1074/jbc.M114.569707 BindingDB Entry DOI: 10.7270/Q2MW2G0Q | |||||||||||
More data for this Ligand-Target Pair |