Affinity Data by PDB ID

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PDB code 5GPG

Identical Ligands in BindingDB

Found 6 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (92/93 = 99%)^† (Homo sapiens (Human))	BDBM36609 (Rapamycin C-7, analog 4 \| SIROLIMUS \| US11603377, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Curated by ChEMBL					Assay Description Inhibition of mTOR kinase expressed in human HEK293 cells by western blot analysis				J Biol Chem 282: 13395-401 (2007) Article DOI: 10.1074/jbc.M700498200 BindingDB Entry DOI: 10.7270/Q2J1042G
Stanford University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase mTOR (92/93 = 99%)^† (Homo sapiens (Human))	BDBM36609 (Rapamycin C-7, analog 4 \| SIROLIMUS \| US11603377, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibitory concentration against FKBP12 receptor				J Med Chem 48: 5613-38 (2005) Article DOI: 10.1021/jm050524f BindingDB Entry DOI: 10.7270/Q2V988V1
The Scripps Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase mTOR (92/93 = 99%)^† (Homo sapiens (Human))	BDBM36609 (Rapamycin C-7, analog 4 \| SIROLIMUS \| US11603377, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Curated by ChEMBL					Assay Description The inhibitory activity by using FK506 binding protein 12 SPA binding assay				Bioorg Med Chem Lett 10: 1007-10 (2000) BindingDB Entry DOI: 10.7270/Q28K7BCP
Glaxo Wellcome Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase mTOR (92/93 = 99%)^† (Homo sapiens (Human))	BDBM36609 (Rapamycin C-7, analog 4 \| SIROLIMUS \| US11603377, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Mansoura University Curated by ChEMBL					Assay Description Inhibition of mTOR (unknown origin) incubated for 1 hr by ELISA				Eur J Med Chem 156: 304-315 (2018) Article DOI: 10.1016/j.ejmech.2018.07.004 BindingDB Entry DOI: 10.7270/Q2J9692K
Mansoura University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase mTOR (92/93 = 99%)^† (Homo sapiens (Human))	BDBM36609 (Rapamycin C-7, analog 4 \| SIROLIMUS \| US11603377, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of mTOR-mediated Akt phosphorylation in human PC3 cells				Bioorg Med Chem Lett 21: 6793-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.035 BindingDB Entry DOI: 10.7270/Q28W3DR1
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase mTOR (92/93 = 99%)^† (Homo sapiens (Human))	BDBM36609 (Rapamycin C-7, analog 4 \| SIROLIMUS \| US11603377, ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a
University of Basel Curated by ChEMBL					Assay Description Binding affinity to mTOR FKBP12 site (unknown origin)				J Med Chem 61: 10084-10105 (2018) Article DOI: 10.1021/acs.jmedchem.8b01262 BindingDB Entry DOI: 10.7270/Q2X92F07
University of Basel Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output