Affinity Data by PubMed id=10072687

PubMed code 10072687

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074629 (4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl...) Show SMILES CC(C)(C)CCC#C[C@@H]1C[C@H]1c1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074627 (4-[2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl]-1H-imi...) Show SMILES CC(C)(C)CCC#CC1CC1c1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070214 (4-(7,7-Dimethyl-oct-3-ynyl)-1H-imidazole \| CHEMBL2...) Show SMILES CC(C)(C)CCC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070220 (4-(6-Cyclopentyl-hex-3-ynyl)-1H-imidazole \| CHEMBL...) Show SMILES C(CC1CCCC1)C#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074630 (4-[2-(4-Cyclopentyl-but-1-ynyl)-cyclopropyl]-1H-im...) Show SMILES C(CC1CCCC1)C#CC1CC1c1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074624 (4-[2-(4-Cyclohexyl-but-1-ynyl)-cyclopropyl]-1H-imi...) Show SMILES C(CC1CCCCC1)C#CC1CC1c1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074628 (4-Undec-3-ynyl-1H-imidazole \| CHEMBL170723) Show SMILES CCCCCCCC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070211 (4-(6-Cyclohexyl-hex-3-ynyl)-1H-imidazole \| CHEMBL1...) Show SMILES C(CC1CCCCC1)C#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070216 (4-(8-Phenyl-oct-3-ynyl)-1H-imidazole \| CHEMBL14811) Show SMILES C(CCc1ccccc1)CC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070212 (4-(7-Methyl-oct-3-ynyl)-1H-imidazole \| CHEMBL14497) Show SMILES CC(C)CCC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074622 (4-(2-Pent-1-ynyl-cyclopropyl)-1H-imidazole \| CHEMB...) Show SMILES CCCC#CC1CC1c1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074632 (4-((1S,2S)-2-(5,5-dimethylhex-1-ynyl)cyclopropyl)-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	5.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074625 (4-Non-3-ynyl-1H-imidazole \| CHEMBL169929) Show SMILES CCCCCC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074623 (4-[2-(5-Methyl-hex-1-ynyl)-cyclopropyl]-1H-imidazo...) Show SMILES CC(C)CCC#CC1CC1c1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074631 (4-[2-(6-Phenyl-hex-1-ynyl)-cyclopropyl]-1H-imidazo...) Show SMILES C(CCc1ccccc1)CC#CC1CC1c1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	15.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070215 (4-Hept-3-ynyl-1H-imidazole \| CHEMBL276804) Show SMILES CCCC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074626 (4-But-3-ynyl-1H-imidazole \| CHEMBL170104) Show SMILES C#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	66.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50070219 (4-Hex-3-ynyl-1H-imidazole \| CHEMBL14721) Show SMILES CCC#CCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Gliatech Inc. Curated by ChEMBL					Assay Description Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.				J Med Chem 42: 903-9 (1999) Article DOI: 10.1021/jm980310g BindingDB Entry DOI: 10.7270/Q2ST7P1D
Gliatech Inc. Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%