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PubMed code 10075775

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Plasminogen activator inhibitor 1


(Homo sapiens (Human))		BDBM50241599
PNG
(CHEMBL453012 | sideroxylonal A)
Show SMILES CC(C)C[C@H]1[C@@H](C(C)C)[C@@H](Oc2c(C=O)c(O)c(C=O)c(O)c12)c1c(O)c(C=O)c(O)c(C=O)c1O |r|
Show InChI InChI=1S/C26H28O10/c1-10(2)5-12-17(11(3)4)26(19-23(34)13(6-27)20(31)14(7-28)24(19)35)36-25-16(9-30)21(32)15(8-29)22(33)18(12)25/h6-12,17,26,31-35H,5H2,1-4H3/t12-,17+,26+/m0/s1
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n/an/a 3.30E+3n/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human PAI1 using tissue type plasminogen activator substrate by plasmon resonance

J Nat Prod 62: 324-6 (1999)


Article DOI: 10.1021/np980286+
BindingDB Entry DOI: 10.7270/Q24Q7TRJ
More data for this
Ligand-Target Pair
Plasminogen activator inhibitor 1


(Homo sapiens (Human))		BDBM50241601
PNG
(CHEMBL453538 | sideroxylonal C)
Show SMILES CC(C)C[C@@H]1[C@@H](C(C)C)[C@@H](Oc2c(C=O)c(O)c(C=O)c(O)c12)c1c(O)c(C=O)c(O)c(C=O)c1O |r|
Show InChI InChI=1S/C26H28O10/c1-10(2)5-12-17(11(3)4)26(19-23(34)13(6-27)20(31)14(7-28)24(19)35)36-25-16(9-30)21(32)15(8-29)22(33)18(12)25/h6-12,17,26,31-35H,5H2,1-4H3/t12-,17-,26-/m1/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human PAI1 using tissue type plasminogen activator substrate by plasmon resonance

J Nat Prod 62: 324-6 (1999)


Article DOI: 10.1021/np980286+
BindingDB Entry DOI: 10.7270/Q24Q7TRJ
More data for this
Ligand-Target Pair
Plasminogen activator inhibitor 1


(Homo sapiens (Human))		BDBM50241600
PNG
(CHEMBL509880 | sideroxylonal B)
Show SMILES CC(C)C[C@H]1[C@H](C(C)C)[C@@H](Oc2c(C=O)c(O)c(C=O)c(O)c12)c1c(O)c(C=O)c(O)c(C=O)c1O |r|
Show InChI InChI=1S/C26H28O10/c1-10(2)5-12-17(11(3)4)26(19-23(34)13(6-27)20(31)14(7-28)24(19)35)36-25-16(9-30)21(32)15(8-29)22(33)18(12)25/h6-12,17,26,31-35H,5H2,1-4H3/t12-,17-,26+/m0/s1
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n/an/a 5.30E+3n/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human PAI1 using tissue type plasminogen activator substrate by plasmon resonance

J Nat Prod 62: 324-6 (1999)


Article DOI: 10.1021/np980286+
BindingDB Entry DOI: 10.7270/Q24Q7TRJ
More data for this
Ligand-Target Pair
Plasminogen activator inhibitor 1


(Homo sapiens (Human))		BDBM50241606
PNG
(CHEMBL454049 | euglobal IA2)
Show SMILES CC(C)C[C@H]1[C@H]2C[C@@H](C=C[C@@]2(C)Oc2c(C=O)c(O)c(C=O)c(O)c12)C(C)C |r,c:8|
Show InChI InChI=1S/C23H30O5/c1-12(2)8-15-18-9-14(13(3)4)6-7-23(18,5)28-22-17(11-25)20(26)16(10-24)21(27)19(15)22/h6-7,10-15,18,26-27H,8-9H2,1-5H3/t14-,15+,18-,23-/m1/s1
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n/an/a 1.38E+5n/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human PAI1 using tissue type plasminogen activator substrate by plasmon resonance

J Nat Prod 62: 324-6 (1999)


Article DOI: 10.1021/np980286+
BindingDB Entry DOI: 10.7270/Q24Q7TRJ
More data for this
Ligand-Target Pair
Plasminogen activator inhibitor 1


(Homo sapiens (Human))		BDBM50241608
PNG
(CHEMBL509920 | robustadial A)
Show SMILES CC(C)C[C@@H]1C[C@@]2(CC[C@@H]3C[C@H]2C3(C)C)Oc2c(C=O)c(O)c(C=O)c(O)c12 |r|
Show InChI InChI=1S/C23H30O5/c1-12(2)7-13-9-23(6-5-14-8-17(23)22(14,3)4)28-21-16(11-25)19(26)15(10-24)20(27)18(13)21/h10-14,17,26-27H,5-9H2,1-4H3/t13-,14-,17+,23-/m1/s1
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n/an/a 1.52E+5n/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human PAI1 using tissue type plasminogen activator substrate by plasmon resonance

J Nat Prod 62: 324-6 (1999)


Article DOI: 10.1021/np980286+
BindingDB Entry DOI: 10.7270/Q24Q7TRJ
More data for this
Ligand-Target Pair
Plasminogen activator inhibitor 1


(Homo sapiens (Human))		BDBM50241607
PNG
(CHEMBL454050 | euglobal IIc)
Show SMILES CC(C)CC(=O)c1c(O)c2C[C@H]3C[C@@H](C=C[C@@]3(C)Oc2c(C=O)c1O)C(C)C |r,c:14|
Show InChI InChI=1S/C23H30O5/c1-12(2)8-18(25)19-20(26)16-10-15-9-14(13(3)4)6-7-23(15,5)28-22(16)17(11-24)21(19)27/h6-7,11-15,26-27H,8-10H2,1-5H3/t14-,15-,23-/m1/s1
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n/an/a 7.00E+5n/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human PAI1 using tissue type plasminogen activator substrate by plasmon resonance

J Nat Prod 62: 324-6 (1999)


Article DOI: 10.1021/np980286+
BindingDB Entry DOI: 10.7270/Q24Q7TRJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%