Found 25 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074768
(2-{2-[Bis-(4-methoxycarbonyl-phenoxy)-phosphoryl]-...)Show SMILES COC(=O)c1ccc(OP(=O)(Oc2ccc(cc2)C(=O)OC)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C25H29N2O8P/c1-32-24(29)17-7-11-19(12-8-17)34-36(31,35-20-13-9-18(10-14-20)25(30)33-2)22-6-4-16-27(22)23(28)21-5-3-15-26-21/h7-14,21-22,26H,3-6,15-16H2,1-2H3/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074760
(2-(2-{Bis-[4-(ethoxycarbonylmethyl-carbamoyl)-phen...)Show SMILES CCOC(=O)CNC(=O)c1ccc(OP(=O)(Oc2ccc(cc2)C(=O)NCC(=O)OCC)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C31H39N4O10P/c1-3-42-27(36)19-33-29(38)21-9-13-23(14-10-21)44-46(41,26-8-6-18-35(26)31(40)25-7-5-17-32-25)45-24-15-11-22(12-16-24)30(39)34-20-28(37)43-4-2/h9-16,25-26,32H,3-8,17-20H2,1-2H3,(H,33,38)(H,34,39)/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074762
(2-{2-[Bis-(4-propylcarbamoyl-phenoxy)-phosphoryl]-...)Show SMILES CCCNC(=O)c1ccc(OP(=O)(Oc2ccc(cc2)C(=O)NCCC)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C29H39N4O6P/c1-3-17-31-27(34)21-9-13-23(14-10-21)38-40(37,26-8-6-20-33(26)29(36)25-7-5-19-30-25)39-24-15-11-22(12-16-24)28(35)32-18-4-2/h9-16,25-26,30H,3-8,17-20H2,1-2H3,(H,31,34)(H,32,35)/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074769
(2-(2-{Bis-[4-(2-methoxycarbonyl-ethylcarbamoyl)-ph...)Show SMILES COC(=O)CCNC(=O)c1ccc(OP(=O)(Oc2ccc(cc2)C(=O)NCCC(=O)OC)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C31H39N4O10P/c1-42-27(36)15-18-33-29(38)21-7-11-23(12-8-21)44-46(41,26-6-4-20-35(26)31(40)25-5-3-17-32-25)45-24-13-9-22(10-14-24)30(39)34-19-16-28(37)43-2/h7-14,25-26,32H,3-6,15-20H2,1-2H3,(H,33,38)(H,34,39)/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074753
(2-{2-[Bis-(4-methanesulfonylamino-phenoxy)-phospho...)Show SMILES CS(=O)(=O)Nc1ccc(OP(=O)(Oc2ccc(NS(C)(=O)=O)cc2)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C23H31N4O8PS2/c1-37(30,31)25-17-7-11-19(12-8-17)34-36(29,35-20-13-9-18(10-14-20)26-38(2,32)33)22-6-4-16-27(22)23(28)21-5-3-15-24-21/h7-14,21-22,24-26H,3-6,15-16H2,1-2H3/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074766
(2-{2-[Bis-(4-acetylamino-phenoxy)-phosphoryl]-pyrr...)Show SMILES CC(=O)Nc1ccc(OP(=O)(Oc2ccc(NC(C)=O)cc2)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C25H31N4O6P/c1-17(30)27-19-7-11-21(12-8-19)34-36(33,35-22-13-9-20(10-14-22)28-18(2)31)24-6-4-16-29(24)25(32)23-5-3-15-26-23/h7-14,23-24,26H,3-6,15-16H2,1-2H3,(H,27,30)(H,28,31)/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074759
(2-(2-{Bis-[4-(2-amino-acetylamino)-phenoxy]-phosph...)Show SMILES NCC(=O)Nc1ccc(OP(=O)(Oc2ccc(NC(=O)CN)cc2)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C25H33N6O6P/c26-15-22(32)29-17-5-9-19(10-6-17)36-38(35,37-20-11-7-18(8-12-20)30-23(33)16-27)24-4-2-14-31(24)25(34)21-3-1-13-28-21/h5-12,21,24,28H,1-4,13-16,26-27H2,(H,29,32)(H,30,33)/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074770
(2-(2-{[4-((R)-2-Amino-propionylamino)-phenoxy]-[4-...)Show SMILES C[C@@H](N)C(=O)Nc1ccc(OP(=O)(Oc2ccc(NC(=O)[C@H](C)N)cc2)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C27H37N6O6P/c1-17(28)25(34)31-19-7-11-21(12-8-19)38-40(37,24-6-4-16-33(24)27(36)23-5-3-15-30-23)39-22-13-9-20(10-14-22)32-26(35)18(2)29/h7-14,17-18,23-24,30H,3-6,15-16,28-29H2,1-2H3,(H,31,34)(H,32,35)/p+1/t17-,18+,23?,24?,40? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074772
(2-(2-{Bis-[4-(2-benzoylamino-acetylamino)-phenoxy]...)Show SMILES O=C(CNC(=O)c1ccccc1)Nc1ccc(OP(=O)(Oc2ccc(NC(=O)CNC(=O)c3ccccc3)cc2)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C39H41N6O8P/c46-34(25-41-37(48)27-9-3-1-4-10-27)43-29-15-19-31(20-16-29)52-54(51,36-14-8-24-45(36)39(50)33-13-7-23-40-33)53-32-21-17-30(18-22-32)44-35(47)26-42-38(49)28-11-5-2-6-12-28/h1-6,9-12,15-22,33,36,40H,7-8,13-14,23-26H2,(H,41,48)(H,42,49)(H,43,46)(H,44,47)/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074756
(2-{2-[Bis-(3-acetylamino-phenoxy)-phosphoryl]-pyrr...)Show SMILES CC(=O)Nc1cccc(OP(=O)(Oc2cccc(NC(C)=O)c2)C2CCCN2C(=O)C2CCC[NH2+]2)c1 Show InChI InChI=1S/C25H31N4O6P/c1-17(30)27-19-7-3-9-21(15-19)34-36(33,35-22-10-4-8-20(16-22)28-18(2)31)24-12-6-14-29(24)25(32)23-11-5-13-26-23/h3-4,7-10,15-16,23-24,26H,5-6,11-14H2,1-2H3,(H,27,30)(H,28,31)/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074767
(2-(2-{Bis-[4-(2-acetylamino-2-methoxycarbonyl-ethy...)Show SMILES COC(=O)C(Cc1ccc(OP(=O)(Oc2ccc(CC(NC(C)=O)C(=O)OC)cc2)C2CCCN2C(=O)C2CCC[NH2+]2)cc1)NC(C)=O Show InChI InChI=1S/C33H43N4O10P/c1-21(38)35-28(32(41)44-3)19-23-9-13-25(14-10-23)46-48(43,30-8-6-18-37(30)31(40)27-7-5-17-34-27)47-26-15-11-24(12-16-26)20-29(33(42)45-4)36-22(2)39/h9-16,27-30,34H,5-8,17-20H2,1-4H3,(H,35,38)(H,36,39)/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074765
(2-{2-[(5-Ureido-cyclohexa-1,3-dienyloxy)-(3-ureido...)Show SMILES NC(=O)NC1CC(OP(=O)(Oc2cccc(NC(N)=O)c2)C2CCCN2C(=O)C2CCC[NH2+]2)=CC=C1 |c:35,37| Show InChI InChI=1S/C23H31N6O6P/c24-22(31)27-15-5-1-7-17(13-15)34-36(33,35-18-8-2-6-16(14-18)28-23(25)32)20-10-4-12-29(20)21(30)19-9-3-11-26-19/h1-2,5-8,13,16,19-20,26H,3-4,9-12,14H2,(H3,24,27,31)(H3,25,28,32)/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074761
((R)-2-[2-(Diphenoxy-phosphoryl)-pyrrolidine-1-carb...)Show SMILES O=C([C@H]1CCC[NH2+]1)N1CCCC1P(=O)(Oc1ccccc1)Oc1ccccc1 Show InChI InChI=1S/C21H25N2O4P/c24-21(19-13-7-15-22-19)23-16-8-14-20(23)28(25,26-17-9-3-1-4-10-17)27-18-11-5-2-6-12-18/h1-6,9-12,19-20,22H,7-8,13-16H2/p+1/t19-,20?/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074752
(2-(2-{Bis-[4-(pyrrolidin-1-ylamino)-phenoxy]-phosp...)Show SMILES O=C(C1CCC[NH2+]1)N1CCCC1P(=O)(Oc1ccc(NN2CCCC2)cc1)Oc1ccc(NN2CCCC2)cc1 Show InChI InChI=1S/C29H41N6O4P/c36-29(27-7-5-17-30-27)35-22-6-8-28(35)40(37,38-25-13-9-23(10-14-25)31-33-18-1-2-19-33)39-26-15-11-24(12-16-26)32-34-20-3-4-21-34/h9-16,27-28,30-32H,1-8,17-22H2/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074758
((S)-2-[2-(Diphenoxy-phosphoryl)-pyrrolidine-1-carb...)Show SMILES O=C([C@@H]1CCC[NH2+]1)N1CCCC1P(=O)(Oc1ccccc1)Oc1ccccc1 Show InChI InChI=1S/C21H25N2O4P/c24-21(19-13-7-15-22-19)23-16-8-14-20(23)28(25,26-17-9-3-1-4-10-17)27-18-11-5-2-6-12-18/h1-6,9-12,19-20,22H,7-8,13-16H2/p+1/t19-,20?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074757
(2-{2-[Bis-(4-methoxy-phenoxy)-phosphoryl]-pyrrolid...)Show SMILES COc1ccc(OP(=O)(Oc2ccc(OC)cc2)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C23H29N2O6P/c1-28-17-7-11-19(12-8-17)30-32(27,31-20-13-9-18(29-2)10-14-20)22-6-4-16-25(22)23(26)21-5-3-15-24-21/h7-14,21-22,24H,3-6,15-16H2,1-2H3/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074751
((S)-2-[2-(6-Oxo-5,7-dioxa-6lambda*5*-phospha-diben...)Show SMILES O=C([C@@H]1CCC[NH2+]1)N1CCCC1P1(=O)Oc2ccccc2-c2ccccc2O1 Show InChI InChI=1S/C21H23N2O4P/c24-21(17-9-5-13-22-17)23-14-6-12-20(23)28(25)26-18-10-3-1-7-15(18)16-8-2-4-11-19(16)27-28/h1-4,7-8,10-11,17,20,22H,5-6,9,12-14H2/p+1/t17-,20?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074764
((S)-2-{2-[(2'-Hydroxy-biphenyl-2-yloxy)-methoxy-ph...)Show SMILES COP(=O)(Oc1ccccc1-c1ccccc1O)C1CCCN1C(=O)[C@@H]1CCC[NH2+]1 Show InChI InChI=1S/C22H27N2O5P/c1-28-30(27,21-13-7-15-24(21)22(26)18-10-6-14-23-18)29-20-12-5-3-9-17(20)16-8-2-4-11-19(16)25/h2-5,8-9,11-12,18,21,23,25H,6-7,10,13-15H2,1H3/p+1/t18-,21?,30?/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Prolyl endopeptidase
(Homo sapiens (Human)) | BDBM50074756
(2-{2-[Bis-(3-acetylamino-phenoxy)-phosphoryl]-pyrr...)Show SMILES CC(=O)Nc1cccc(OP(=O)(Oc2cccc(NC(C)=O)c2)C2CCCN2C(=O)C2CCC[NH2+]2)c1 Show InChI InChI=1S/C25H31N4O6P/c1-17(30)27-19-7-3-9-21(15-19)34-36(33,35-22-10-4-8-20(16-22)28-18(2)31)24-12-6-14-29(24)25(32)23-11-5-13-26-23/h3-4,7-10,15-16,23-24,26H,5-6,11-14H2,1-2H3,(H,27,30)(H,28,31)/p+1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
Effect of the compound on the activity of prolyl endopeptidase (PEP) was evaluated at 1 mM concentration for DPP IV |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Aminopeptidase N
(Homo sapiens (Human)) | BDBM50074761
((R)-2-[2-(Diphenoxy-phosphoryl)-pyrrolidine-1-carb...)Show SMILES O=C([C@H]1CCC[NH2+]1)N1CCCC1P(=O)(Oc1ccccc1)Oc1ccccc1 Show InChI InChI=1S/C21H25N2O4P/c24-21(19-13-7-15-22-19)23-16-8-14-20(23)28(25,26-17-9-3-1-4-10-17)27-18-11-5-2-6-12-18/h1-6,9-12,19-20,22H,7-8,13-16H2/p+1/t19-,20?/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
Effect of the compound on the activity of membrane alanyl aminopeptidase (MAAP) is evaluated at at a concentration of 1 mM. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Prolyl endopeptidase
(Homo sapiens (Human)) | BDBM50074756
(2-{2-[Bis-(3-acetylamino-phenoxy)-phosphoryl]-pyrr...)Show SMILES CC(=O)Nc1cccc(OP(=O)(Oc2cccc(NC(C)=O)c2)C2CCCN2C(=O)C2CCC[NH2+]2)c1 Show InChI InChI=1S/C25H31N4O6P/c1-17(30)27-19-7-3-9-21(15-19)34-36(33,35-22-10-4-8-20(16-22)28-18(2)31)24-12-6-14-29(24)25(32)23-11-5-13-26-23/h3-4,7-10,15-16,23-24,26H,5-6,11-14H2,1-2H3,(H,27,30)(H,28,31)/p+1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
Effect of the compound on the activity of prolyl endopeptidase (PEP) was evaluated at the IC50 concentration for DPP IV and |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Aminopeptidase N
(Homo sapiens (Human)) | BDBM50074760
(2-(2-{Bis-[4-(ethoxycarbonylmethyl-carbamoyl)-phen...)Show SMILES CCOC(=O)CNC(=O)c1ccc(OP(=O)(Oc2ccc(cc2)C(=O)NCC(=O)OCC)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C31H39N4O10P/c1-3-42-27(36)19-33-29(38)21-9-13-23(14-10-21)44-46(41,26-8-6-18-35(26)31(40)25-7-5-17-32-25)45-24-15-11-22(12-16-24)30(39)34-20-28(37)43-4-2/h9-16,25-26,32H,3-8,17-20H2,1-2H3,(H,33,38)(H,34,39)/p+1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.04E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
Effect of the compound on the activity of membrane alanyl aminopeptidase (MAAP) is evaluated at the IC50 concentration for DPPIV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074754
(2-{2-[Bis-(4-hydroxy-phenoxy)-phosphoryl]-pyrrolid...)Show SMILES Oc1ccc(OP(=O)(Oc2ccc(O)cc2)C2CCCN2C(=O)C2CCC[NH2+]2)cc1 Show InChI InChI=1S/C21H25N2O6P/c24-15-5-9-17(10-6-15)28-30(27,29-18-11-7-16(25)8-12-18)20-4-2-14-23(20)21(26)19-3-1-13-22-19/h5-12,19-20,22,24-25H,1-4,13-14H2/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074763
(2-{2-[Bis-(2,2,2-trichloro-ethoxy)-phosphoryl]-pyr...)Show SMILES ClC(Cl)(Cl)COP(=O)(OCC(Cl)(Cl)Cl)C1CCCN1C(=O)C1CCC[NH2+]1 Show InChI InChI=1S/C13H19Cl6N2O4P/c14-12(15,16)7-24-26(23,25-8-13(17,18)19)10-4-2-6-21(10)11(22)9-3-1-5-20-9/h9-10,20H,1-8H2/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.80E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50074755
(2-{2-[Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-pyr...)Show SMILES FC(F)(F)COP(=O)(OCC(F)(F)F)C1CCCN1C(=O)C1CCC[NH2+]1 Show InChI InChI=1S/C13H19F6N2O4P/c14-12(15,16)7-24-26(23,25-8-13(17,18)19)10-4-2-6-21(10)11(22)9-3-1-5-20-9/h9-10,20H,1-8H2/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.10E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UIA)
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 42: 1041-52 (1999)
Article DOI: 10.1021/jm981033g
BindingDB Entry DOI: 10.7270/Q2RV0MW5 |
More data for this
Ligand-Target Pair | |
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